Skip to main content

Advertisement

SpringerLink
Log in

Psoas muscle mass in patients undergoing lung cancer surgery: a prognostic difference between squamous cell carcinoma and adenocarcinoma

  • Original Article
  • Published:
International Journal of Clinical Oncology Aims and scope Submit manuscript

Abstract

Background

Psoas muscle mass is a surrogate marker for sarcopenia: a depletion of skeletal muscle mass. This study was conducted to elucidate the prognostic significance of the psoas muscle index (PMI: cross-sectional area of the bilateral psoas muscle at the umbilical level on computed tomography/height2 [cm2/m2]) in patients undergoing surgery for lung squamous cell carcinoma (SCC) and lung adenocarcinoma (ADC).

Methods

One hundred and sixty-five patients with SCC and 556 patients with ADC who underwent R0 resection between 2007 and 2014 were reviewed for analysis. In SCC patients, the mean value (standard deviation) of the PMI was 6.15 (1.49) in men and 4.65 (1.36) in women. Among ADC patients, the PMI was 7.12 (1.60) in men and 5.29 (1.22) in women. Clinicopathological characteristics as well as the survival were evaluated.

Results

The PMI was associated with the age, body mass index (BMI), and serum albumin. In the multivariable Cox regression analysis, after adjusting for age, BMI, serum albumin, sex, pathological stage, and diffusing capacity for carbon monoxide, the PMI showed a significant association with the overall survival (OS) and disease-free survival (DFS) in SCC patients (hazard ratios 0.50 and 0.56, 95% confidence intervals 0.39–0.65 and 0.45–0.71, respectively). On the other hand, in ADC patients, the PMI had no impact on the OS or DFS.

Conclusions

The PMI was significantly associated with the survival of lung SCC patients, but not of lung ADC patients, suggesting the presence of a previously unidentified relationship between skeletal muscle and lung SCC progression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Rosenberg IH (1989) Summary comments. Am J Clin Nutr 50:1231–1233

    Article  Google Scholar 

  2. Okumura S, Kaido T, Hamaguchi Y et al (2015) Impact of preoperative quality as well as quantity of skeletal muscle on survival after resection of pancreatic cancer. Surgery 157:1088–1098

    Article  PubMed  Google Scholar 

  3. Onesti JK, Wright GP, Kenning SE et al (2016) Sarcopenia and survival in patients undergoing pancreatic resection. Pancreatology 16:284–289

    Article  PubMed  Google Scholar 

  4. Yaguchi Y, Kumata Y, Horikawa M et al (2017) Clinical significance of area of psoas major muscle on computed tomography after gastrectomy in gastric cancer patients. Ann Nutr Metab 71:145–149

    Article  CAS  PubMed  Google Scholar 

  5. Cornet M, Lim C, Salloum C et al (2015) Prognostic value of sarcopenia in liver surgery. J Visc Surg 152:297–304

    Article  CAS  PubMed  Google Scholar 

  6. Smith AB, Deal AM, Yu H et al (2014) Sarcopenia as a predictor of complications and survival following radical cystectomy. J Urol 191:1714–1720

    Article  PubMed  Google Scholar 

  7. Park SY, Yoon JK, Lee SJ et al (2017) Prognostic value of preoperative total psoas muscle area on long-term outcome in surgically treated oesophageal cancer patients. Interact CardioVasc Thorac Surg 24:13–19

    Article  PubMed  Google Scholar 

  8. Yoshikawa T, Takano M, Miyamoto M et al (2017) Psoas muscle volume as a predictor of peripheral neurotoxicity induced by primary chemotherapy in ovarian cancers. Cancer Chemother Pharmacol 80:555–561

    Article  CAS  PubMed  Google Scholar 

  9. Suzuki Y, Okamoto T, Fujishita T et al (2016) Clinical implications of sarcopenia in patients undergoing complete resection for early non-small cell lung cancer. Lung Cancer 101:92–97

    Article  PubMed  Google Scholar 

  10. Hervochon R, Bobbio A, Guinet C et al (2017) Body mass index and total psoas area affect outcomes in patients undergoing pneumonectomy for cancer. Ann Thorac Surg 103:287–295

    Article  PubMed  Google Scholar 

  11. Nakamura R, Inage Y, Tobita R et al (2018) Sarcopenia in resected NSCLC: effect on postoperative outcomes. J Thorac Oncol 13:895–903

    Article  PubMed  Google Scholar 

  12. Sun C, Anraku M, Karasaki T et al (2018) Low truncal muscle area on chest computed tomography: a poor prognostic factor for the cure of early-stage non-small-cell lung cancer. Eur J Cardiothorac Surg 55:414–420

    Article  Google Scholar 

  13. Ozeki N, Fukui T, Taniguchi T et al (2014) Significance of the serum carcinoembryonic antigen level during the follow-up of patients with completely resected non-small-cell lung cancer. Eur J Cardiothorac Surg 45:687–692

    Article  PubMed  Google Scholar 

  14. Brierley JD, Gospodarowicz MK, Wittekind C (2016) TNM classification of malignant tumours, 8th edn. Wiley-Blackwell, New York

    Google Scholar 

  15. Travis WD, Brambilla E, Burke AP et al (2015) WHO classification of tumours of the lung, pleura, thymus and heart. IARC Press, Lyon

    Google Scholar 

  16. Kurokawa T, Matsuno Y, Noguchi M et al (1994) Surgically curable “early” adenocarcinoma in the periphery of the lung. Am J Surg Pathol 18:431–438

    Article  CAS  PubMed  Google Scholar 

  17. Ozeki N, Kawaguchi K, Fukui T et al (2017) The diffusing capacity of the lung for carbon monoxide is associated with the histopathological aggressiveness of lung adenocarcinoma. Eur J Cardiothorac Surg 52:969–974

    Article  PubMed  Google Scholar 

  18. Ozeki N, Kawaguchi K, Okasaka T et al (2017) Marginal pulmonary function is associated with poor short- and long-term outcomes in lung cancer surgery. Nagoya J Med Sci 79:37–42

    PubMed  PubMed Central  Google Scholar 

  19. Attaran S, McShane J, Whittle I et al (2012) A propensity-matched comparison of survival after lung resection in patients with a high versus low body mass index. Eur J Cardiothorac Surg 42:653–658

    Article  PubMed  Google Scholar 

  20. Ozeki N, Fukui T, Kawaguchi K et al (2018) A survival analysis using physique-adjusted tumor size of non-small cell lung cancer. Int J Clin Oncol 23:266–274

    Article  PubMed  Google Scholar 

  21. Miura K, Hamanaka K, Koizumi T et al (2017) Clinical significance of preoperative serum albumin level for prognosis in surgically resected patients with non-small cell lung cancer: comparative study of normal lung, emphysema, and pulmonary fibrosis. Lung Cancer 111:88–95

    Article  PubMed  Google Scholar 

  22. Pedersen BK, Febbraio MA (2012) Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8:457–465

    Article  CAS  PubMed  Google Scholar 

  23. Takamori S, Toyokawa G, Okamoto T et al (2018) Clinical impact and risk factors for skeletal muscle loss after complete resection of early non-small cell lung cancer. Ann Surg Oncol 25:1229–1236

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Naoki Ozeki, Koji Kawaguchi, Takayuki Fukui, Shota Nakamura, Shuhei Hakiri, Shunsuke Mori, Masaki Goto, Kohei Yokoi & Toyofumi Fengshi Chen-Yoshikawa

  2. Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Shingo Iwano

Authors
  1. Naoki Ozeki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Koji Kawaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takayuki Fukui
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shota Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shuhei Hakiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shunsuke Mori
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masaki Goto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Shingo Iwano
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Kohei Yokoi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Toyofumi Fengshi Chen-Yoshikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Naoki Ozeki.

Ethics declarations

Conflict of interest

The authors have declared that no conflict of interest exists.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ozeki, N., Kawaguchi, K., Fukui, T. et al. Psoas muscle mass in patients undergoing lung cancer surgery: a prognostic difference between squamous cell carcinoma and adenocarcinoma. Int J Clin Oncol 25, 876–884 (2020). https://doi.org/10.1007/s10147-020-01624-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10147-020-01624-x

Keywords

Search

Navigation