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Long-term outcomes and prognostic factors of pulmonary metastasectomy for osteosarcoma and soft tissue sarcoma

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Abstract

Background

The prognostic factors of pulmonary metastasectomy in patients with osteosarcoma and soft tissue sarcoma remain controversial. The purpose of our analysis was to explore the prognostic factors and outcomes of patients with osteosarcoma and soft tissue sarcoma who underwent pulmonary metastasectomy at our institution.

Methods

We reviewed the data of 44 patients who underwent resection of pulmonary metastases from 1996 to 2016 at our institution. The Kaplan–Meier method, log-rank test and multivariate Cox hazard model were used for comparison and survival analyses.

Results

There was no perioperative mortality. The median post-metastasectomy overall survival was 24.8 months, and the 5-year overall survival rate of all patients was 43.5%. The 5-year survival rate of the patients who underwent repeat thoracotomies was 60.0%. Incomplete resection, a largest tumor size > 2 cm and a disease-free interval < 12 months were associated with poor survival in multivariate analyses. Among eight patients, who underwent repeat pulmonary resection, two remain alive with no evidence of disease. These patients had the longest DFI and DFI-2 (time from first pulmonary metastasectomy to the diagnosis of recurrent pulmonary metastasis), respectively.

Conclusion

The survival of patients with a relatively long disease-free interval, small tumor size and complete resection was favorable following the treatment of osteosarcoma and soft tissue sarcoma with pulmonary metastasectomy. Repeat pulmonary metastasectomies also provide favorable prognosis in select patients.

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Authors and Affiliations

  1. Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-2 (L5), Yamadaoka, Suita, Osaka, 565-0871, Japan

    Yoko Yamamoto, Ryu Kanzaki, Takashi Kanou, Naoko Ose, Soichiro Funaki, Yasushi Shintani, Masato Minami & Meinoshin Okumura

  2. Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Hidetatsu Outani, Satoshi Takenaka, Kenichiro Hamada & Hideki Yoshikawa

Authors
  1. Yoko Yamamoto
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  2. Ryu Kanzaki
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  3. Takashi Kanou
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  4. Naoko Ose
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  5. Soichiro Funaki
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  6. Yasushi Shintani
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  7. Masato Minami
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  8. Hidetatsu Outani
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  9. Satoshi Takenaka
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  10. Kenichiro Hamada
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  11. Hideki Yoshikawa
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  12. Meinoshin Okumura
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Corresponding author

Correspondence to Ryu Kanzaki.

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The authors declare that they have no conflicts of interest.

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Yamamoto, Y., Kanzaki, R., Kanou, T. et al. Long-term outcomes and prognostic factors of pulmonary metastasectomy for osteosarcoma and soft tissue sarcoma. Int J Clin Oncol 24, 863–870 (2019). https://doi.org/10.1007/s10147-019-01422-0

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  • DOI: https://doi.org/10.1007/s10147-019-01422-0

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