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Clinical outcomes of radiotherapy for esophageal cancer between 2004 and 2008: the second survey of the Japanese Radiation Oncology Study Group (JROSG)

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Abstract

Background

This second questionnaire-based survey was performed to determine the clinical results of definitive esophageal cancer treatment with radiotherapy (RT) or chemoradiotherapy (CRT) between 2004 and 2008.

Materials/methods

Clinical results of definitive RT for patients were collected from major Japanese institutions. Patients were classified into three groups: (A) stage I, (B) resectable stages II–III, (C) unresectable stages III–IVA. For group A, all patients treated with RT alone or CRT were included. For groups B and C, only those treated with CRT were included.

Results

In total, 990 patients (group A 259, group B 333, group C 398 patients) were included from 11 institutions. In group A, 199 patients (78 %) were treated with CRT, and 60 patients (23 %) received RT alone. In groups B and C, 420 patients (57 %) were treated with full-dose cisplatin/5-FU, and 181 patients (25 %) with low-dose protracted-infusion cisplatin/5-FU. The median and range of the 5-year overall survival rate were 73 % (40–94 %) for group A, 40 % (0–57 %) for group B, and 18 % (6–26 %) for group C, respectively. The 5-year overall survival rates were consistently good for five high-volume centers where more than 20 patients/year with esophageal cancer were treated definitively as compared with the remaining six medium-volume centers (5–15 patients/year). The median and range of the incidence of grade ≥3 late toxicities were 10 % and 6–22 %, respectively.

Conclusions

A wide disparity in 5-year overall survival rates among the institutions was still apparent in the second survey for groups A and B.

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References

  1. Al-Sarraf M, Herskovic A, Martz K et al (1997) Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: an intergroup study. J Clin Oncol 15:277–284

    CAS  PubMed  Google Scholar 

  2. Cooper JS, Guo MD, Herskovic A et al (1999) Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group. JAMA 281:1623–1627

    Article  CAS  PubMed  Google Scholar 

  3. Smith TJ, Ryan LM, Douglass HO Jr et al (1998) Combined chemoradiotherapy vs. radiotherapy alone for early stage squamous cell carcinoma of the esophagus: a study of the Eastern Cooperative Oncology Group. Int J Radiat Oncol Biol Phys 42:269–276

    Article  CAS  PubMed  Google Scholar 

  4. Nishimura Y, Suzuki M, Nakamatsu K et al (2002) Prospective trial of concurrent chemoradiotherapy with protracted infusion of 5-fluorouracil and cisplatin for T4 esophageal cancer with or without fistula. Int J Radiat Oncol Biol Phys 53:134–139

    Article  CAS  PubMed  Google Scholar 

  5. Ohtsu A, Boku N, Muro K et al (1999) Definitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carcinoma of the esophagus. J Clin Oncol 17:2915–2921

    CAS  PubMed  Google Scholar 

  6. Sakai K, Inakoshi H, Sueyama H et al (1995) Concurrent radiotherapy and chemotherapy with protracted continuous infusion of 5-fluorouracil in inoperable esophageal squamous cell carcinoma. Int J Radiat Oncol Biol Phys 31:921–927

    Article  CAS  PubMed  Google Scholar 

  7. Hironaka S, Ohtsu A, Boku N et al (2003) Nonrandomized comparison between definitive chemoradiotherapy and radical surgery in patients with T(2–3) N(any) M(0) squamous cell carcinoma of the esophagus. Int J Radiat Oncol Biol Phys 57:425–433

    Article  PubMed  Google Scholar 

  8. Murakami M, Kuroda Y, Nakajima T et al (1999) Comparison between chemoradiation protocol intended for organ preservation and conventional surgery for clinical T1–T2 esophageal carcinoma. Int J Radiat Oncol Biol Phys 45:277–284

    Article  CAS  PubMed  Google Scholar 

  9. Ariga H, Nemoto K, Miyazaki S et al (2009) Prospective comparison of surgery alone and chemoradiotherapy with selective surgery in resectable squamous cell carcinoma of the esophagus. Int J Radiat Oncol Biol Phys 75:348–356

    Article  PubMed  Google Scholar 

  10. Nishimura Y, Okuno Y, Ono K et al (1999) External-beam radiation therapy with or without high-dose-rate intraluminal brachytherapy for superficial esophageal cancer. Cancer 86:220–228

    Article  CAS  PubMed  Google Scholar 

  11. Sai H, Mitsumori M, Araki N et al (2005) Long-term results of definitive radiotherapy for stage I esophageal cancer. Int J Radiat Oncol Biol Phys 62:1339–1344

    Article  PubMed  Google Scholar 

  12. Nemoto K, Matsumoto Y, Yamakawa M et al (2000) Treatment of superficial esophageal cancer by external radiation therapy alone: results of a multi-institutional experience. Int J Radiat Oncol Biol Phys 46:921–925

    Article  CAS  PubMed  Google Scholar 

  13. Nemoto K, Yamada S, Hareyama M et al (2001) Radiation therapy for superficial esophageal cancer: a comparison of radiotherapy methods. Int J Radiat Oncol Biol Phys 50:639–644

    Article  CAS  PubMed  Google Scholar 

  14. Kato H, Sato A, Fukuda H et al (2009) A phase II trial of chemoradiotherapy for stage I esophageal squamous cell carcinoma: Japan Clinical Oncology Group Study (JCOG9708). Jpn J Clin Oncol 39:638–643

    Article  PubMed  Google Scholar 

  15. Murakami Y, Kenjo M, Uno T et al (2007) Results of the 1999-2001 Japanese patterns of care study for patients receiving definitive radiation therapy without surgery for esophageal cancer. Jpn J Clin Oncol 37:493–500

    Article  PubMed  Google Scholar 

  16. Kenjo M, Uno T, Murakami Y et al (2009) Radiation therapy for esophageal cancer in Japan: results of the Patterns of Care Study 1999–2001. Int J Radiat Oncol Biol Phys 75:357–363

    Article  PubMed  Google Scholar 

  17. Kuwano H, Nishimura Y, Oyama T et al (2015) Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus April 2012 edited by the Japan Esophageal Society. Esophagus 12:1–30

  18. Nishimura Y, Koike R, Ogawa K et al (2012) Clinical practice and outcome of radiotherapy for esophageal cancer between 1999 and 2003: The Japanese Radiation Oncology Study Group (JROSG) survey. Int J Clin Oncol 17:48–54

    Article  PubMed  Google Scholar 

  19. Nishimura Y, Hiraoka M, Koike R et al (2012) Long-term follow-up of a randomized phase II study of cisplatin/5-FU concurrent chemoradiotherapy for esophageal cancer (KROSG0101/JROSG021). Jpn J Clin Oncol 42:807–812

    Article  PubMed  Google Scholar 

  20. Sakayauchi T, Nemoto K, Ishioka C et al (2009) Comparison of cisplatin and 5-fluorouracil chemotherapy protocols combined with concurrent radiotherapy for esophageal cancer. Jpn J Radiol 27:131–137

  21. Sai H, Mitsumori M, Yamauchi C et al (2004) Concurrent chemoradiotherapy for esophageal cancer: comparison between intermittent standard-dose cisplatin with 5-fluorouracil and daily low-dose cisplatin with continuous infusion of 5-fluorouracil. Int J Clin Oncol 9:149–153

    Article  CAS  PubMed  Google Scholar 

  22. Yamada K, Murakami M, Okamoto Y et al (2006) Treatment results of chemoradiotherapy for clinical stage I (T1N0M0) esophageal cancer. Int J Radiat Oncol Biol Phys 64:1106–1111

    Article  PubMed  Google Scholar 

  23. Nemoto K, Matsushita H, Ogawa Y et al (2003) Radiation therapy combined with cis-diammine-glycolatoplatinum (Nedaplatin) and 5-fluorouracil for untreated and recurrent esophageal cancer. Am J Clin Oncol 26:46–49

  24. Sasamoto R, Sakai K, Inakoshi H et al (2007) Long-term results of chemoradiotherapy for locally advanced esophageal cancer, using daily low-dose 5-fluorouracil and cis-diammine-dichloro-platinum (CDDP). Int J Clin Oncol 12:25–30

  25. Hihara J, Yoshida K, Hamai Y et al (2007) Phase I study of docetaxel (TXT) and 5-fluorouracil (5-FU) with concurrent radiotherapy in patients with advanced esophageal cancer. Anticancer Res 27(4C):2597–2603

    CAS  PubMed  Google Scholar 

  26. Minsky BD, Pajak TF, Ginsberg RJ et al (2002) INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy. J Clin Oncol 20:1167–1174

    Article  CAS  PubMed  Google Scholar 

  27. Shinoda M, Ando N, Kato K et al (2015) Randomized study of low-dose versus standard-dose chemoradiotherapy for unresectable esophageal squamous cell carcinoma (JCOG0303). Cancer Sci 106:407–412. doi:10.1111/cas.12622

  28. Fujita H, Ozawa S, Kuwano H et al (2010) Esophagectomy for cancer: clinical concerns support centralization operations within the larger hospitals. Dis Esophagus 23:145–152

    Article  CAS  PubMed  Google Scholar 

  29. Ishikura S, Nihei K, Ohtsu A et al (2003) Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus. J Clin Oncol 21:2697–2702

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was partially supported by Health Sciences Research Grants for a Grant-in-Aid for Cancer Research (H23-009, H26-090) from the Ministry of Health, Labor and Welfare of Japan, and the National Cancer Center Research and Development Funds (26-A-4).

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Authors and Affiliations

  1. Department of Radiation Oncology, Kinki University Faculty of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan

    Yasumasa Nishimura

  2. Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8574, Japan

    Keiichi Jingu

  3. Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan

    Satoshi Itasaka

  4. Department of Radiology, Tenri Hospital, Tenri, Nara, 632-8552, Japan

    Yoshiharu Negoro

  5. Department of Radiation Oncology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, 734-8551, Japan

    Yuji Murakami

  6. Division of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, 113-8677, Japan

    Katsuyuki Karasawa

  7. Department of Radiation Oncology, Niigata University Medical and Dental Hospital, Niigata, 951-8510, Japan

    Gen Kawaguchi

  8. Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan

    Fumiaki Isohashi

  9. Department of Radiology, Jikei University School of Medicine, Tokyo, 105-8471, Japan

    Masao Kobayashi

  10. Department of Radiology, Nagoya University, Nagoya, Aichi, 466-8550, Japan

    Yoshiyuki Itoh

  11. Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, 903-0215, Japan

    Takuro Ariga

Authors
  1. Yasumasa Nishimura
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  2. Keiichi Jingu
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  3. Satoshi Itasaka
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  4. Yoshiharu Negoro
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  5. Yuji Murakami
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  6. Katsuyuki Karasawa
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  7. Gen Kawaguchi
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  8. Fumiaki Isohashi
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  9. Masao Kobayashi
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  10. Yoshiyuki Itoh
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  11. Takuro Ariga
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Correspondence to Yasumasa Nishimura.

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Nishimura, Y., Jingu, K., Itasaka, S. et al. Clinical outcomes of radiotherapy for esophageal cancer between 2004 and 2008: the second survey of the Japanese Radiation Oncology Study Group (JROSG). Int J Clin Oncol 21, 88–94 (2016). https://doi.org/10.1007/s10147-015-0872-x

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  • DOI: https://doi.org/10.1007/s10147-015-0872-x

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