Abstract
Background
The long-term outcomes of definitive concurrent chemoradiotherapy for patients with esophageal submucosal cancer without regional and distant metastasis were retrospectively analyzed.
Methods
Patients with histologically confirmed esophageal submucosal cancers without regional and distant metastasis who received definitive concurrent chemoradiotherapy from 2001 to 2011 were included. Radiation therapy of a median total dose of 60 Gy/30 fractions (range, 54–66 Gy) with elective nodal irradiation of 40 Gy was combined concurrently with 5-furuorouracil-based chemotherapy.
Results
Thirty-six patients (33 men and 3 women) aged from 45 to 80 years (median, 67 years) were assessed. All patients had squamous cell carcinoma. With a median follow-up time of 61 months, the 5-year overall survival, disease-free survival, and locoregional failure-free survival rates were 86 % [95 % confidence interval (CI), 74–99 %], 59 % (95 % CI, 42–77 %), and 90 % (95 % CI, 79–100 %), respectively. Late toxicities of grade 3 pleural effusion in 2 patients, grade 4 pericardial effusion in 1 patient, and grade 5 pneumonitis in 1 patient were observed. Metachronous esophageal cancer was observed in 8 patients (22 %). Among them, 6 patients with mucosal legions were salvaged by endoscopic resection.
Conclusion
Our long-term results of concurrent chemoradiotherapy (CCRT) for patients with esophageal submucosal cancer showed acceptable toxicities and favorable locoregional control and survivals while maintaining organ preservation.
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References
Hareyama M, Nishio M, Kagami Y et al (1992) Intracavitary brachytherapy combined with external-beam irradiation for squamous cell carcinoma of the thoracic esophagus. Int J Radiat Oncol Biol Phys 24:235–240
Okawa T, Dokiya T, Nishio M et al (1999) Multi-institutional randomized trial of external radiotherapy with or without intraluminal brachytherapy for esophageal cancer in Japan. Int J Radiat Oncol Biol Phys 45:623–628
Yorozu A, Dokiya T, Oki Y (1999) High-dose-rate brachytherapy boost following concurrent chemoradiotherapy for esophageal carcinoma. Int J Radiat Oncol Biol Phys 45:271–275
Maingon P, Hombres A, Truc G et al (2000) High dose rate brachytherapy for superficial cancer of the esophagus. Int J Radiat Oncol Biol Phys 46:71–76
Ishikawa H, Nonaka T, Sakurai H et al (2010) Usefulness of intraluminal brachytherapy combined with external beam radiation therapy for submucosal esophageal cancer: long-term follow-up results. Int J Radiat Oncol Biol Phys 76:452–459
Yamada K, Murakami M, Okamoto Y et al (2006) Treatment results of chemoradiotherapy for clinical stage I (T1N0M0) esophageal cancer. Int J Radiat Oncol Biol Phys 64:1106–1111
Kato H, Sato A, Fukuda H et al (2009) A phase II trial of chemoradiotherapy for stage I esophageal squamous cell carcinoma: Japan Clinical Oncology Group study (JCOG9708). Jpn J Clin Oncol 39:638–643
Murakami Y, Nagata Y, Nishibuchi I et al (2012) Long-term outcomes of intraluminal brachytherapy in combination with external beam radiotherapy for superficial esophageal cancer. Int J Clin Oncol 17:263–271
Ozawa S, Tachimori Y, Baba H et al (2012) Comprehensive Registry of Esophageal Cancer in Japan, 2004. Esophagus 9:75–98
Nishimaki T, Tanaka O, Suzuki T et al (1993) Tumor spread in superficial esophageal cancer: histopathologic basis for rational surgical treatment. World J Surg 17:766–772
Makuuchi H, Shimada H, Mizutani K et al (1997) Clinical pathological analysis of surgically resected superficial esophageal carcinoma to determine criteria for deciding on treatment strategy. Diagn Ther Endosc 3:211–220
Tachibana M, Yoshimura H, Kinugasa S et al (1997) Clinicopathological features of superficial squamous cell carcinoma of the esophagus. Am J Surg 174:49–53
Kodama M, Kakegawa T (1998) Treatment of superficial cancer of the esophagus: a summary of responses to a questionnaire on superficial cancer of the esophagus in Japan. Surgery (St. Louis) 123:432–439
Endo M, Yoshino K, Kawano T et al (2000) Clinicopathologic analysis of lymph node metastasis in surgically resected superficial cancer of the thoracic esophagus. Dis Esophagus 13:125–129
Bollschweiler E, Baldus SE, Schröder W et al (2006) High rate of lymph-node metastasis in submucosal esophageal squamous-cell carcinomas and adenocarcinomas. Endoscopy 38:149–156
Takahashi H, Arimura Y, Hosokawa M et al (2010) Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video). Gastrointest Endosc 72:255–264
Altorki NK, Lee PC, Liss Y, Meherally D et al (2008) Multifocal neoplasia and nodal metastases in T1 esophageal carcinoma: implications for endoscopic treatment. Ann Surg 247:434–439
Tachibana T, Matono S, Nagano T et al (2012) Esophagectomy with extended lymphadenectomy for submucosal esophageal cancer: long-term outcomes and prognostic factors. Ann Surg Oncol 19:750–756
Nemoto K, Yamada S, Nishio M et al (2006) Results of radiation therapy for superficial esophageal cancer using the standard radiotherapy method recommended by the Japanese Society of Therapeutic Radiology and Oncology (JASTRO) Study Group. Anticancer Res 26:1507–1512
Murakami Y, Kenjo M, Uno T et al (2007) Results of the 1999–2001 Japanese Patterns of Care Study for patients receiving definitive radiation therapy without surgery for esophageal cancer. Jpn J Clin Oncol 37:493–500
Herskovic A, Martz K, Al-Sarraf M et al (1992) Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med 326:1593–1598
Al-Sarraf M, Martz K, Herskovic A et al (1997) Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: an intergroup study. J Clin Oncol 15:277–284
Cooper JS, Guo MD, Herskovic A et al (1999) Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01) Radiation Therapy Oncology Group. JAMA 281:1623–1627
Gasper L, Winter K, Kocha W et al (2000) A phase I/II study of external beam radiation, brachytherapy, and concurrent chemotherapy for patients with localized carcinoma of the esophagus (Radiation Therapy Oncology Group Study 9207). Cancer (Phila) 88:988–995
Shimizu Y, Tukagoshi H, Fujita M et al (2001) Metachronous squamous cell carcinoma of the esophagus arising after endoscopic mucosal resection. Gastrointest Endosc 54:190–194
Urabe Y, Hiyama T, Tanaka S et al (2009) Metachronous multiple esophageal squamous cell carcinomas and Lugol-voiding lesions after endoscopic mucosal resection. Endoscopy 41:304–309
Adams MJ, Hardenbergh PH, Constine LS et al (2003) Radiation-associated cardiovascular disease. Crit Rev Oncol Hematol 45:55–75
Ishikura S, Nihei K, Ohtsu A et al (2003) Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus. J Clin Oncol 21:2697–2702
Lin SH, Wang L, Myles B et al (2012) Propensity score-based comparison of long-term outcomes with 3-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy for esophageal cancer. Int J Radiat Oncol Biol Phys 84:1078–1085
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Murakami, Y., Takahashi, I., Nishibuchi, I. et al. Long-term results of definitive concurrent chemoradiotherapy for patients with esophageal submucosal cancer (T1bN0M0). Int J Clin Oncol 20, 897–904 (2015). https://doi.org/10.1007/s10147-015-0819-2
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DOI: https://doi.org/10.1007/s10147-015-0819-2