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Efficacy of compound topical anesthesia combined with photobiomodulation therapy in pain control for placement of orthodontic miniscrew: a double-blind, randomized clinical trial

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Abstract

This study aims to investigate the effect of compound topical anesthetic (CTA) application combined with photobiomodulation therapy (PBMT) on the level of pain perceived during placement of miniscrews and 24 h post the procedure in the buccal side of the maxillary bone. This randomized, prospective, single-center, split-mouth, double-blinded study included 25 subjects (12 males and 13 females, aged 16 to 35). Two anesthetic techniques before implantation were performed including Profound gel +PBM with 980 nm diode laser and local anesthesia with 2% lidocaine hydrochloride. Then, the miniscrews with the size of 1.6 mm in diameter and 8 mm in length were placed with a hand driver in the buccal side of the maxillary bone. The pain immediately after miniscrew placement (T1), also 12 h (T2), and 24 h (T3) post the procedure were collected by visual analog scale (VAS). Data were analyzed by SPSS version 22. There were no statistically significant differences in mean VAS scores within or between CTA combined with PBMT or injection applications, immediately after miniscrew placement (P = 0.75), 12 h after miniscrew placement (P = 0.4), and 24 h after miniscrew placement (P = 1.0). Compound topical anesthetic combined with PBMT provided adequate local anesthesia for the placement of miniscrews in the buccal side of the maxillary bone.

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Author information

Authors and Affiliations

  1. Dental Sciences Research Center, Department of Orthodontics, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran

    Farhad Sobouti

  2. Dental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Qouds Ave, Tehran, 1441987566, Iran

    Nasim Chiniforush

  3. Student Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran

    Hamid Jaahed Saravani

  4. Department of Orthodontics, Student Research Committee, School of dentistry, Ilam University of Medical Sciences, Ilam, Iran

    Mohammad Noroozian

  5. School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

    Mark Cronshaw

  6. Leicester School of Pharmacy, De Montfort University, Leicester, UK

    Mark Cronshaw

  7. Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran

    Reza Alizadeh Navaei

  8. Private practice, Tehran, Iran

    Vahid Rakhshan

  9. Dental Sciences Research Center, Department of Orthodontics, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran

    Sepideh Dadgar

Authors
  1. Farhad Sobouti
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  2. Nasim Chiniforush
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  3. Hamid Jaahed Saravani
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  4. Mohammad Noroozian
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  5. Mark Cronshaw
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  6. Reza Alizadeh Navaei
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  7. Vahid Rakhshan
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  8. Sepideh Dadgar
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Corresponding authors

Correspondence to Nasim Chiniforush or Sepideh Dadgar.

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Ethics approval

This study has been approved by ethical committee of Mazandaran University of Medical Sciences (approval code: IR.MAZUMS.REC.1399.427) and also was registered in the Iranian registry of clinical trial (IRCT20200616047801N1).

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Informed consent was taken from patients prior to treatment.

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The authors declare no competing interests.

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Sobouti, F., Chiniforush, N., Saravani, H.J. et al. Efficacy of compound topical anesthesia combined with photobiomodulation therapy in pain control for placement of orthodontic miniscrew: a double-blind, randomized clinical trial. Lasers Med Sci 37, 589–594 (2022). https://doi.org/10.1007/s10103-021-03307-z

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  • DOI: https://doi.org/10.1007/s10103-021-03307-z

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