Abstract
Primary bone xanthoma is a rare type of tumor, and those developing primarily within the skull are even more unusual. In this case, a primary bone xanthoma of the clivus without endocrine or metabolic complications represents the first of this type to be reported. The patient, a 24-year-old woman, initially experienced frequent headaches. Subsequent skull tomography and bone-window computed tomography (CT) revealed a clearly demarcated osteolytic lesion in the clivus. T1-weighted magnetic resonance imaging (MRI) exhibited low intensity, and T2-weighted MRI showed iso-high intensity and a heterogeneously faint contrast effect. The tumor was completely resected, after which the patient’s headaches disappeared completely. Because xanthoma is devoid of neoplastic features, it does not necessarily require aggressive therapy. Therefore, it is very important to understand the characteristics of its clinical symptoms and to give due consideration to differential diagnosis based on pathological presentations and imaging features. This study introduces information regarding a bone xanthoma originating within the skull, together with a review of bone xanthoma literature.
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References
Inserra S, Einhorn TA, Vigorita VJ, Smith AG (1984) Intraosseous xanthoma associated with hyperlipoproteinemia: a case report. Clin Orthop Relat Res 187:218–222
Kovac A, Kuo YZ, Sagar V (1976) Radiographic and radioisotope evaluation of intra-osseous xanthoma. Br J Radiol 49:281–285
Bertoni F, Unni KK, McLeod RA, Sim FH (1988) Xanthoma of bone. Am J Clin Pathol 90:377–384
Kuroiwa T, Ohta T, Tsutsumi A (2000) Xanthoma of the temporal bone: case report. Neurosurgery 46:996–998
Yokoyama E, Ito J, Tokiguchi S et al (1990) A case of xanthoma of the skull. Jpn J Clin Radiol 35:1057–1060 (Jpn)
Huang CF, Cheng SN, Hung CH et al (2000) Xanthoma of bone in a normolipidemic child: report of one case. Acta Paediatr Taiwan 41:158–160
Koch HJ Jr, Lewis JS (1956) Hyperlipemic xanthomatosis with associated osseous granuloma; a clinical report. N Engl J Med 255:387–388
Tadmor R, Davis KR, Roberson GH, New PF, Taveras JM (1977) Computed tomography in extra-dural epidermoid and xanthoma. Surg Neurol 7:371–375
Emery PJ, Gore M (1982) An extensive solitary xanthoma of the temporal bone, associated with hyperlipoproteinaemia. J Laryngol Otol 96:451–457
Ferlito A, Recher G, Bordin S (1983) Involvement of the temporal bone in hyperlipidemic xanthomatosis. Otolaryngol Head Neck Surg 91:100–104
Jackler RK, Brackmann DE (1987) Xanthoma of the temporal bone and skull base. Am J Otol 8:111–115
Friedman O, Hockstein N, Willcox TO Jr, Keane WM (2000) Xanthoma of the temporal bone: a unique case of this rare condition. Ear Nose Throat J 79:433–436
Matoba M, Tonami H, Kuginuki M et al (2004) CT and MRI findings of xanthoma in the orbitofrontal region. Radiat Med 22:116–119
Elwood ET, Shahwan TG, Dajani N, Murray JD (2005) Isolated xanthoma of the frontal bone. J Craniofac Surg 16:391–394
Alden KJ, McCarthy EF, Weber KL (2008) Xanthoma of bone: a report of three cases and review of the literature. Iowa Orthop J 28:58–64
Muthusamy KA, Azmi K, Narayanan P et al (2008) Bilateral temporal bone xanthoma. Case report. J Neurosurg 108:361–364
Turk C, Bılgıner B, Benlı K et al (2010) Bilateral temporal bone xanthomas in type ii hypercholesterolemia. Turk Neurosurg 20:533–535
Walton KW, Thomas C, Dunkerley DJ (1973) The pathogenesis of xanthomata. J Pathol 109:271–289
Mishkel MA, Cockshott WP, Nazir DJ et al (1977) Xanthoma disseminatum. Clinical, metabolic, pathologic, and radiologic aspects. Arch Dermatol 113:1094–1100
Plester D, Steinbach E (1982) Cholesterol granuloma. Otolaryngol Clin N Am 15:665–672
Brown RV, Sage MR, Brophy BP (1990) CT and MR findings in patients with chordomas of the petrous apex. AJNR Am J Neuroradiol 11:121–124
Meyers SP, Hirsch WL Jr, Curtin HD et al (1992) Chordomas of the skull base: MR features. AJNR Am J Neuroradiol 13(6):1627–1636
Lim GH (1975) Clivus chordoma with unusual bone sclerosis and brainstem invasion. A case report with review of the radiology of cranial chordomas. Australas Radiol 19:242–250
Ferry AP, Haddad HM, Goldman JL (1981) Orbital invasion by an intracranial chordoma. Am J Ophthalmol 92:7–12
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The authors express their deep gratitude to Professor Osami Kubo, Department of Neurosurgery, Tokyo Women’s Medical University, for valuable discussion and advice leading to completion of this manuscript.
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Asano, K., Sato, J., Matsuda, N. et al. A rare case of primary bone xanthoma of the clivus. Brain Tumor Pathol 29, 123–128 (2012). https://doi.org/10.1007/s10014-011-0073-x
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DOI: https://doi.org/10.1007/s10014-011-0073-x