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Advanced platelet-rich-fibrin (A-PRF +) has no additional effect on the healing of post-extraction sockets of upper third molars. A split mouth randomized clinical trial

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Abstract

Purpose

This study evaluated  the effects of advanced platelet-rich fibrin (A-PRF +) on the healing of upper third molar post-extraction sockets.

Methods

Sixteen patients who underwent extractions of the upper third molars (18 and 28) were included in this randomized split-mouth study. The alveoli on the test side were filled with A-PRF + , while the control side was maintained with blood clot. The side that received treatment was randomly defined. Alveolar bone regeneration was evaluated by CBCT scans to assess healing stage, bone density, and fractal analysis 1 week and 90 days post-extraction. Additionally, pain, edema, bleeding, and soft tissue alveolar repair were evaluated by clinical analyses 3, 7, 14, 30, and 90 days after the surgical procedure using a visual analog scale.

Results

There were no clinical differences regarding treatments in any experimental period. In the tomographic evaluation, at 7 days, the alveoli treated with A-PRF + presented a suggestive sign of higher bone density than the control alveoli, which was not confirmed 90 days after the surgical procedure.

Conclusion

Thus, the use of A-PRF + does not demonstrate a clinical advantage in the repair of post-extraction sockets of upper third molars.

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Funding

This study was funded by the National Council for Scientific and Technological Development (CNPq—Conselho Nacional de Desenvolvimento Científico e Tecnológico) (Project 426954–2018-1).

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Authors and Affiliations

  1. Department of Periodontology, School of Dentistry, Federal University of Uberlandia - UFU, Uberlândia, MG, Brazil

    Davisson Alves Pereira, Pedro Gomes Junqueira Mendes, Nuryê Rezende Prisinoto, Priscilla Barbosa Ferreira Soares & Guilherme José Pimentel Lopes de Oliveira

  2. Department of Oral Diagnosis, School of Dentistry, Federal University of Uberlandia - UFU, Uberlândia, MG, Brazil

    Gabriella Lopes de Rezende Barbosa

Authors
  1. Davisson Alves Pereira
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  2. Pedro Gomes Junqueira Mendes
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  5. Priscilla Barbosa Ferreira Soares
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  6. Guilherme José Pimentel Lopes de Oliveira
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Davisson Alves Pereira, Pedro Gomes Junqueira Mendes, Nuryê Rezende Prisinoto, Gabriella Lopes de Rezende Barbosa, and Priscilla Barbosa Ferreira Soares. The first draft of the manuscript was written by Davisson Alves Pereira and Guilherme José Pimentel Lopes de Oliveira and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Guilherme José Pimentel Lopes de Oliveira.

Ethics declarations

Ethics approval

This study was approved by the Research Ethics Committee of the Federal University of Uberlândia under protocol number CAAE: 37924720.3.0000.5152 and it was registered in the Brazilian Registry of Clinical Trials (REBEC) under number U1111-1263–9675.

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All individuals who participated in this study signed an informed consent form.

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Not applicable.

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The authors declare no competing interests.

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Pereira, D.A., Mendes, P.G.J., Prisinoto, N.R. et al. Advanced platelet-rich-fibrin (A-PRF +) has no additional effect on the healing of post-extraction sockets of upper third molars. A split mouth randomized clinical trial. Oral Maxillofac Surg 27, 411–419 (2023). https://doi.org/10.1007/s10006-022-01075-w

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