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Basaloid squamous cell carcinoma: a 31-year retrospective study and analysis of 214 cases reported in the literature

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Abstract

Purpose

The aim of this study was to analyze the clinical features of BSCC in the oral cavity, diagnosed over 31 years of service in oral pathology, and make comparisons with the data reported in the literature.

Methods

Data regarding gender, age, clinical presentation, anatomical location, symptoms, evolution time, size of lesion, and use of alcohol and tobacco from cases of BSCC were collected. Additionally, we conducted a review of BSCC studies from searches in three electronic databases.

Results

Among 24,570 oral biopsies, 7 (0.03%) were BSCC and represented 0.8% of oral squamous cell carcinoma (n = 875). All cases occurred in males, and the prevalent affected age was the sixth decade (60%). Ulcers occurred in all cases, with the majority showing no symptoms (71.4%). The tongue (30.8%), alveolar ridge/gingiva (30.8%), and floor of the mouth (23.1%) were the anatomical locations affected. The literature review indicated a total of fifteen publications, reporting 214 cases of BSCC. Males (76.7%) in the seventh (53.3%) decade of life were most affected. According to the cases with adequate information, symptomatic (90.0%) ulcers (80.0%) in the floor of the mouth (42.1%), with a mean size of 2 cm and the mean evolution time of 1.5 to 18 months were the most seen. Association with tobacco and alcohol use, when noted, was 50.0%.

Conclusion

The features presented in this study are more similar than different when compared with the literature data.

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Acknowledgments

This work was supported by the Brazilian National Council for Scientific and Technological Development (CNPq) and Coordination for the Improvement of Higher Education Personnel (CAPES). LFS is a scholarship recipient.

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Authors and Affiliations

  1. Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Lauren Frenzel Schuch

  2. Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627. Sala 3202 D. Pampulha, Belo Horizonte, MG, Zip code: 31.270-010, Brazil

    Lauren Frenzel Schuch

  3. Dental School, Federal University of Pelotas, Pelotas, Brazil

    Kaio Heide Sampaio Nóbrega, Ana Paula Neutzling Gomes & Ana Carolina Uchoa Vasconcelos

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  1. Lauren Frenzel Schuch
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  2. Kaio Heide Sampaio Nóbrega
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  3. Ana Paula Neutzling Gomes
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  4. Ana Carolina Uchoa Vasconcelos
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Correspondence to Lauren Frenzel Schuch.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Schuch, L.F., Nóbrega, K.H.S., Gomes, A.P.N. et al. Basaloid squamous cell carcinoma: a 31-year retrospective study and analysis of 214 cases reported in the literature. Oral Maxillofac Surg 24, 103–108 (2020). https://doi.org/10.1007/s10006-020-00828-9

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