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A new cone-beam computed tomography–driven index for osteoporosis prediction

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Clinical Oral Investigations Aims and scope Submit manuscript

Abstract

Objective

To verify whether mandibular cortical analyses accurately distinguish postmenopausal women with normal bone mineral density (BMD) from women with osteoporosis by means of a cone-beam computed tomography (CBCT)–driven composite osteoporosis index (three-dimensional mandibular osteoporosis index—3D MOI).

Material and methods

The comparison was performed between 52 women with normal BMD and 51 women with osteoporosis according to dual-energy X-ray absorptiometry (DXA) examination of the lumbar spine and hip. Mandibular cortical width (MCW) and cortical quality were evaluated on cross-sectional and panoramic reconstructed images. ANOVA, ROC curves and accuracy measurements were used for statistical analyses, as well as a predictive model combining the quantitative and qualitative analyses and age.

Results

All CBCT-driven measurements presented good to moderate intra- and interobserver agreements. MCW values were significantly lower in women with osteoporosis. Postmenopausal women with osteoporosis were 8 times more likely to have the cortex classified as C3, and 2.4 times more likely to have MCW thinner than 2.75 mm. The area under the ROC curve was 0.8 for the predictive model.

Conclusions

The newly developed 3D MOI enables distinguishing women with osteoporosis from those with normal BMD with good sensitivity and specificity.

Clinical relevance

Whenever a CBCT scan is performed for specific clinical indications, a 3D MOI may be performed to qualitatively and quantitatively assess the condition of the mandibular cortex. This may be surely helpful to assess the osteoporosis status in the ageing population and more specifically in peri- or postmenopausal women.

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Funding

The study received financial support from Fundação de Apoio à Pesquisa do Distrito Federal–FAP-DF.

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Authors and Affiliations

  1. Department of Dentistry, Faculty of Health Sciences, University of Brasilia, Campus Universitário Darcy Ribeiro, Brasília, Zip Code 70910-900, Brazil

    Julia Gonçalves Koehne de Castro, Bruno Fontenele Carvalho, Nilce Santos de Melo, Paulo Tadeu de Souza Figueiredo, Carla Ruffeil Moreira-Mesquita & André Ferreira Leite

  2. Department Imaging and Pathology, Biomedical Sciences, Omfsimpath Research Group, KULeuven and Dentomaxillofacial Imaging Department, University Hospitals Leuven, Leuven, Belgium

    Karla de Faria Vasconcelos, Reinhilde Jacobs & André Ferreira Leite

  3. Department Dental Medicine, Karolinska Institutet, Huddinge, Sweden

    Reinhilde Jacobs

Authors
  1. Julia Gonçalves Koehne de Castro
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  2. Bruno Fontenele Carvalho
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  3. Nilce Santos de Melo
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  4. Paulo Tadeu de Souza Figueiredo
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  5. Carla Ruffeil Moreira-Mesquita
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  6. Karla de Faria Vasconcelos
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  7. Reinhilde Jacobs
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  8. André Ferreira Leite
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Corresponding author

Correspondence to André Ferreira Leite.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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de Castro, J.G.K., Carvalho, B.F., de Melo, N.S. et al. A new cone-beam computed tomography–driven index for osteoporosis prediction. Clin Oral Invest 24, 3193–3202 (2020). https://doi.org/10.1007/s00784-019-03193-4

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  • DOI: https://doi.org/10.1007/s00784-019-03193-4

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