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Oral disorders in patients with newly diagnosed haematological diseases

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Abstract

Objective

This study aimed to examine saliva flow rates and prevalence of dental and periodontal diseases of patients with newly diagnosed severe haematological diseases and compare these findings with age-matched controls of normal population.

Methods

A total of 149 patients diagnosed with haematological diseases aimed to be treated with haematological stem cell transplantation between 2008 and 2018 and 154 controls were included in the study. A dental examination was performed for patients within a maximum of 6 months after diagnosis. Differences were compared in terms of the stimulated salivary flow rate (SSFR); decayed, missing and filled teeth (DMFT) index; number of teeth; caries prevalence; presence of periodontitis and acute infections.

Results

The mean SSFR of the patient group was significantly lower (1.1 ml/min ± 0.7 ml/min) than the mean SSFR of the controls (1.3 ml/min ± 0.5 ml/min; p = 0.004). The number of caries lesions was significantly higher in the patient group (mean ± SD, 1.1 ± 1.9) than in the control group (mean ± SD, 0.4 ± 1.2; p < 0.001). There were fewer teeth and a higher DMFT index in the patient group compared to the control group, but the differences were not significant. Acute symptomatic infections were observed in eight (5.4%) patients and in none of the controls (p < 0.01).

Conclusions and clinical relevance

Oral examinations in patients with newly diagnosed severe haematological disease demonstrated a higher prevalence of caries, acute infections and lower mean SSFR compared with the controls. These findings support the recommendations for early dental examination at the time of diagnosis.

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Acknowledgements

We thank Andreas Schötzau for providing help and guidance with the statistical analysis.

Author information

Author notes

  1. Mauramo Matti and Waltimo Tuomas contributed equally to this work.

Authors and Affiliations

  1. Department of Oral Health & Medicine, University Center for Dental Medicine Basel, University of Basel, Hebelstrasse 3, CH-4055, Basel, Switzerland

    Uutela Pauliina & Waltimo Tuomas

  2. Department of Hematology, University Hospital, Basel, Switzerland

    Passweg Jakob

  3. Department of Reconstructive Dentistry, School of Dental Medicine, UZB University Center for Dental Medicine, Basel, Switzerland

    Tim Joda

  4. Department of Periodontology, Endodontology and Cariology, UZB University Center for Dental Medicine, Basel, Switzerland

    Roland Weiger

  5. Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    Mauramo Matti

  6. Department of Pathology, Haartman Institute and HUSLab, Helsinki University Central Hospital, Helsinki, Finland

    Mauramo Matti

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  1. Uutela Pauliina
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Corresponding author

Correspondence to Uutela Pauliina.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was conducted in accordance with the Declaration of Helsinki and was approved by the regional ethics committee (Ethikkommision Nordwest- und Zentralschweiz (EKNZ), Switzerland: EKNZ: 311-10 and EKNZ: 2017–02268).

Informed consent

Informed consent was obtained from all the patients participating in 2018 (EKNZ: 2017-02268), the former data was collected retrospectively and formal consent was not required (EKNZ: 311-10).

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Pauliina, U., Jakob, P., Joda, T. et al. Oral disorders in patients with newly diagnosed haematological diseases. Clin Oral Invest 24, 3085–3091 (2020). https://doi.org/10.1007/s00784-019-03178-3

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