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In vivo and in vitro assessment of the bleaching effectiveness of a brush-off patch containing 3.0% hydrogen peroxide

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Abstract

Objectives

To evaluate the efficacy of a brush-off patch containing 3.0% hydrogen peroxide, which is a new over-the-counter (OTC) product for tooth whitening, and determine the optimal protocol for use.

Materials and methods

We performed an in vitro study using hydroxyapatite specimens and a clinical trial involving 140 volunteers. The brush-off patch was applied to the specimens (in vitro) or the maxillary anterior teeth (in vivo; 14 days) for 10 min twice daily (case 10 group) or 30 min once daily (case 30 group). We also included control groups in both experiments. Lightness (L*), redness (a*), and yellowness (b*) values were measured using a colorimeter. In the in vivo study, color changes were measured at baseline and 7 and 14 days after the start of patch application. The overall color change (ΔE) was statistically analyzed.

Results

In the in vitro study, the color change (ΔE*) after the experiment was significantly different between the two case groups and the control group (p < 0.001). In the in vivo study, the case groups showed color changes at both 7 and 14 days after patch application. In particular, the change in the case 30 group was significantly more prominent on day 14 than on day 7 (p < 0.05).

Conclusion

Our findings suggest that brush-off patches containing 3.0% hydrogen peroxide are effective OTC products for tooth whitening.

Clinical relevance

For best results, brush-off patches containing 3.0% hydrogen peroxide can be applied once daily for 30 min.

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Acknowledgments

We thank all the participants of this study and Editage (www.editage.com) for English language editing and publication support. We also thank LG H&H and the researchers for their efforts.

Funding

The authors do not have any financial interest in the companies whose materials are included in this article.

Author information

Authors and Affiliations

  1. Department of Preventive Dentistry, School of Dentistry, Kyungpook National University, 2177, Dalgubeol-daero, Jung-gu, Daegu, 41940, Republic of Korea

    Yun-Sook Jung, Min-Jeong Cho, Youn-Hee Choi & Keun-Bae Song

  2. Department of Dental Hygiene, College of Science & Technology, Kyungpook National University, 2559, Gyeongsang-daero, Sangju-si, Gyeongsangbuk-do, Republic of Korea

    Hwa-Young Jo

  3. LG Household & Health Care Co. Research Park, 175, Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea

    Jae-Hyun Ahn & Ji Young Kim

  4. Department of Conservative Dentistry, School of Dentistry, Kyungpook National University, 2177, Dalgubeol-daero, Jung-gu, Daegu, 41940, Republic of Korea

    Myoung-Uk Jin

Authors
  1. Yun-Sook Jung
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  2. Hwa-Young Jo
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  3. Jae-Hyun Ahn
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  4. Ji Young Kim
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  5. Myoung-Uk Jin
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  6. Min-Jeong Cho
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  7. Youn-Hee Choi
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  8. Keun-Bae Song
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Corresponding author

Correspondence to Keun-Bae Song.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study has been approved by the appropriate ethics committee (Daegu, South Korea; approval no. 2016-0093). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Jung, YS., Jo, HY., Ahn, JH. et al. In vivo and in vitro assessment of the bleaching effectiveness of a brush-off patch containing 3.0% hydrogen peroxide. Clin Oral Invest 23, 2667–2673 (2019). https://doi.org/10.1007/s00784-018-2675-8

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  • DOI: https://doi.org/10.1007/s00784-018-2675-8

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