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Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis

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Abstract

Introduction

This study investigated the relationship between serum 25-hydroxyvitamin D (25OHD) levels and the occurrence of hip fractures in the elderly using a systematic review and meta-analysis approach.

Materials and methods

PubMed, Web of Science, and Scopus were used to identify studies that outlined an association between serum 25OHD and the occurrence of a hip fracture in a geriatric patient. The analysis calculated odds ratios (OR) for a hip fracture using a random-effects model.

Results

In this study, 28 studies were included, 61,744 elderlies and 9767 cases (15.81%) of hip fractures. In the lowest vs. highest categories of vitamin D in the elderly, pooled OR of hip fractures was 1.80 (95% CI 1.56–2.07, P ≤ 0.001), and modified OR was equal to 1.40 (95% CI 1.20–1.63 P ≤ 0.001). A subgroup analysis showed that the OR of a hip fracture was 2.16 (1.49–3.11, P ≤ 0.001) in case–control studies; 1.52 (1.29–1.79, P = 0.001) in cohort studies; and 1.41 (1.18–1.70, P ≤ 0.001) in case–cohort studies.

Conclusion

Low serum vitamin D levels in the elderly are associated with an increase in the odds of hip fracture.

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References

  1. Neo JJ, Kong KH (2016) Prevalence of vitamin D deficiency in elderly patients admitted to an inpatient rehabilitation unit in tropical Singapore (in eng). Rehabil Res Pract 2016:9689760–9689860. https://doi.org/10.1155/2016/9689760

    Article  PubMed  PubMed Central  Google Scholar 

  2. Fang F, Wei H, Wang K, Tan L, Zhang W, Ding L, Liu T, Shan Z, Zhu M (2018) High prevalence of vitamin D deficiency and influencing factors among urban and rural residents in Tianjin, China (in eng). Arch Osteoporos 13:64. https://doi.org/10.1007/s11657-018-0479-8

    Article  PubMed  Google Scholar 

  3. Aspell N, Laird E, Healy M, Shannon T, Lawlor B, O’Sullivan M (2019) The Prevalence and determinants of vitamin D status in community-dwelling older adults: results from the English longitudinal study of ageing (ELSA) (in eng). Nutrients 11:1253. https://doi.org/10.3390/nu11061253

    Article  CAS  PubMed Central  Google Scholar 

  4. Song H-R, Kweon S-S, Choi J-S, Rhee J-A, Lee Y-H, Nam H-S, Jeong S-K, Park K-S, Ryu S-Y, Choi S-W, Shin M-H (2014) High prevalence of vitamin D deficiency in adults aged 50 years and older in Gwangju, Korea: the Dong-gu study (in eng). J Korean Med Sci 29:149–152. https://doi.org/10.3346/jkms.2014.29.1.149

    Article  CAS  PubMed  Google Scholar 

  5. Tabrizi R, Moosazadeh M, Akbari M, Dabbaghmanesh MH, Mohamadkhani M, Asemi Z, Heydari ST, Akbari M, Lankarani KB (2018) High prevalence of vitamin D deficiency among Iranian population: a systematic review and meta-analysis (in eng). Iran J Med Sci 43:125–139

    PubMed  PubMed Central  Google Scholar 

  6. Dehghani Firouzabadi R, Davar R, Hojjat F, Mahdavi M (2013) Effect of sildenafil citrate on endometrial preparation and outcome of frozen-thawed embryo transfer cycles: a randomized clinical trial (in eng). Iran J Reprod Med 11:151–158

    PubMed  PubMed Central  Google Scholar 

  7. Hanley DA, Cranney A, Jones G, Whiting SJ, Leslie WD, Cole DE, Atkinson SA, Josse RG, Feldman S, Kline GA, Rosen C (2010) Vitamin D in adult health and disease: a review and guideline statement from osteoporosis Canada (in eng). Can Med Assoc J 182:E610–E618. https://doi.org/10.1503/cmaj.080663

    Article  Google Scholar 

  8. Kweder H, Eidi H (2018) Vitamin D deficiency in elderly: risk factors and drugs impact on vitamin D status (in eng). Avicenna J Med 8:139–146. https://doi.org/10.4103/ajm.AJM_20_18

    Article  PubMed  PubMed Central  Google Scholar 

  9. Ceolin G, Matsuo LH, Confortin SC, D’Orsi E, Rieger DK, Moreira JD (2020) Lower serum 25-hydroxycholecalciferol is associated with depressive symptoms in older adults in Southern Brazil. Nutr J 19:123. https://doi.org/10.1186/s12937-020-00638-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Fleet JC (2017) The role of vitamin D in the endocrinology controlling calcium homeostasis (in eng). Mol Cell Endocrinol 453:36–45. https://doi.org/10.1016/j.mce.2017.04.008

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Laird E, Ward M, McSorley E, Strain JJ, Wallace J (2010) Vitamin D and bone health: potential mechanisms (in eng). Nutrients 2:693–724. https://doi.org/10.3390/nu2070693

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Moe SM (2008) Disorders involving calcium, phosphorus, and magnesium. Prim Care: Clin Off Pract 35:215–237

    Article  Google Scholar 

  13. Saponaro F, Saba A, Zucchi R (2020) An update on vitamin D metabolism (in eng). Int J Mol Sci 21:6573. https://doi.org/10.3390/ijms21186573

    Article  CAS  PubMed Central  Google Scholar 

  14. Guerra MT, Feron ET, Viana RD, Maboni J, Pastore SI, Castro CC (2016) Elderly with proximal hip fracture present significantly lower levels of 25-hydroxyvitamin D (in eng). Rev Bras Ortop 51:583–588. https://doi.org/10.1016/j.rboe.2016.08.013

    Article  PubMed  PubMed Central  Google Scholar 

  15. Yu SJ, Yang Y, Zang JC, Li C, Wang YM, Wang JB (2021) Evaluation of serum 25-hydroxyvitamin D(3) and bone mineral density in 268 patients with hip fractures (in eng). Orthop Surg 13:892–899. https://doi.org/10.1111/os.12920

    Article  PubMed  PubMed Central  Google Scholar 

  16. Hektoen LF, Saltvedt I, Sletvold O, Helbostad JL, Lurås H, Halsteinli V (2016) One-year health and care costs after hip fracture for home-dwelling elderly patients in Norway: results from the Trondheim hip fracture trial (in eng). Scand J Public Health Suppl 44:791–798. https://doi.org/10.1177/1403494816674162

    Article  Google Scholar 

  17. Amarilla-Donoso FJ, López-Espuela F, Roncero-Martín R, Leal-Hernandez O, Puerto-Parejo LM, Aliaga-Vera I, Toribio-Felipe R, Lavado-García JM (2020) Quality of life in elderly people after a hip fracture: a prospective study (in eng). Health Qual Life Outcomes 18:71–71. https://doi.org/10.1186/s12955-020-01314-2

    Article  PubMed  PubMed Central  Google Scholar 

  18. Sammut R, Azzopardi C, Camilleri L (2021) Spiritual coping strategies and quality of life in older adults who have sustained a hip fracture: a cross-sectional survey (in eng). Nurs Open 8:572–581. https://doi.org/10.1002/nop2.662

    Article  PubMed  Google Scholar 

  19. Prieto-Alhambra D, Moral-Cuesta D, Palmer A, Aguado-Maestro I, Bardaji MFB et al (2019) The impact of hip fracture on health-related quality of life and activities of daily living: the SPARE-HIP prospective cohort study (in eng). Arch Osteoporos 14:56. https://doi.org/10.1007/s11657-019-0607-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Tourlouki E, Matalas A-L, Panagiotakos DB (2009) Dietary habits and cardiovascular disease risk in middle-aged and elderly populations: a review of evidence. Clin Interv Aging 4:319

    Article  Google Scholar 

  21. Ford DW, Jensen GL, Hartman TJ, Wray L, Smiciklas-Wright H (2013) Association between dietary quality and mortality in older adults: a review of the epidemiological evidence. J Nutr Gerontol Geriatr 32:85–105

    Article  Google Scholar 

  22. Pierce MB, Sheehan NW, Ferris AM (2002) Nutrition concerns of low-income elderly women and related social support. J Nutr Health Aging 21:37–53

    Google Scholar 

  23. Dargent-Molina P, Favier F, Grandjean H, Baudoin C, Schott A, Hausherr E, Meunier P, Breart G, E Group (1996) Fall-related factors and risk of hip fracture: the EPIDOS prospective study. Lancet 348:145–149

    Article  CAS  Google Scholar 

  24. Dontas I, Yiannakopoulos C (2007) Risk factors and prevention of osteoporosis-related fractures. J Musculoskelet Neuronal Interact 7:268–272

    CAS  PubMed  Google Scholar 

  25. Feng Y, Cheng G, Wang H, Chen B (2017) The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture (in eng). Osteoporos Int 28:1641–1652. https://doi.org/10.1007/s00198-017-3955-x

    Article  CAS  PubMed  Google Scholar 

  26. Wang N, Chen Y, Ji J, Chang J, Yu S, Yu B (2020) The relationship between serum vitamin D and fracture risk in the elderly: a meta-analysis (in eng). J Orthop Surg Res 15:81–81. https://doi.org/10.1186/s13018-020-01603-y

    Article  PubMed  PubMed Central  Google Scholar 

  27. Lai JK, Lucas RM, Clements MS, Roddam AW, Banks E (2010) Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies (in eng). BMC Public Health 10:331. https://doi.org/10.1186/1471-2458-10-331

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Yao P, Bennett D, Mafham M, Lin X, Chen Z, Armitage J, Clarke R (2019) Vitamin D and calcium for the prevention of fracture: a systematic review and meta-analysis (in eng). JAMA Netw Open 2:e1917789. https://doi.org/10.1001/jamanetworkopen.2019.17789

    Article  PubMed  PubMed Central  Google Scholar 

  29. Lo CK-L, Mertz D, Loeb M (2014) Newcastle-Ottawa scale: comparing reviewers’ to authors’ assessments (in eng). BMC Med Res Methodol 14:45–45. https://doi.org/10.1186/1471-2288-14-45

    Article  PubMed  PubMed Central  Google Scholar 

  30. Wells GA, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 30 Mar 2018.

  31. Sakuma M, Endo N (2006) The relationship between vitamin D insufficiency and hip fracture. Osteoporos Int 16:1968–1972

    CAS  Google Scholar 

  32. Shi S, Pan W, Wu G, Lu D, Li M, Cao S, Zhen Y (2020) Serum 25-hydroxyvitamin D levels in elderly patients with hip and vertebral compression fracture. Chin Gen Pract 19:233–237. https://doi.org/10.3760/cma.j.issn.1671-7368.2020.03.009

    Article  Google Scholar 

  33. Erem C, Tanakol R, Alagol F, Omer B, Cetin O (2002) Relationship of bone turnover parameters, endogenous hormones and vit D deficiency to hip fracture in elderly postmenopausal women. Int J Clin Pract 56:333–337

    CAS  PubMed  Google Scholar 

  34. Lau EM, Woo J, Swaminathan R, MacDonald D, Donnan SP (1989) Plasma 25-hydroxyvitamin D concentration in patients with hip fracture in Hong Kong (in eng). Gerontology 35:198–204. https://doi.org/10.1159/000213023

    Article  CAS  PubMed  Google Scholar 

  35. Detienne S, Vandewoude M, Suy R (2010) Vitamin D and nutritional supplements in the revalidation of older people after hip surgery. Eur Geriatr Med 1:142–145. https://doi.org/10.1016/j.eurger.2010.05.007

    Article  Google Scholar 

  36. Li S, Ou Y, Zhang H, Zhang Z, Zhou H, Liu L, Sheng Z, Liao E (2014) Vitamin D status and its relationship with body composition, bone mineral density and fracture risk in urban central south Chinese postmenopausal women. Ann Nutr Metab 64:13–19. https://doi.org/10.1159/000358340

    Article  CAS  PubMed  Google Scholar 

  37. Di Monaco M, Castiglioni C, Di Monaco R, Tappero R (2016) Time trend 2000–2013 of vitamin D status in older people who sustain hip fractures: steps forward or steps back? A retrospective study of 1599 patients. Eur J Phys Rehabil Med 52:502–507

    Google Scholar 

  38. Nurmi I, Kaukonen JP, Luthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M (2005) Half of the patients with an acute hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. Osteoporos Int 16:2018–2024. https://doi.org/10.1007/s00198-005-1987-0

    Article  CAS  PubMed  Google Scholar 

  39. Pieper CF, Colon-Emeric C, Caminis J, Betchyk K, Zhang J, Janning C, Shostak J, LeBoff MS, Heaney RR, Lyles KW (2007) Distribution and correlates of serum 25-hydroxyvitamin D levels in a sample of patients with hip fracture (in eng). Am J Geriatr Pharmacother 5:335–340. https://doi.org/10.1016/j.amjopharm.2007.12.004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Ramason R, Selvaganapathi N, Ismail NHB, Wong WC, Rajamoney GN, Chong MS (2014) Prevalence of vitamin D deficiency in patients with hip fracture seen in an orthogeriatric service in sunny Singapore. Geriatr Orthop Surg Rehabil 5:82–86. https://doi.org/10.1177/2151458514528952

    Article  PubMed  PubMed Central  Google Scholar 

  41. Shinkov A, Borissova AM, Dakovska L, Vlahov J, Kassabova L, Svinarov D, Krivoshiev S (2016) Differences in the prevalence of vitamin D deficiency and hip fractures in nursing home residents and independently living elderly. Arch Endocrinol Metab 60:217–222. https://doi.org/10.1590/2359-3997000000109

    Article  PubMed  Google Scholar 

  42. Tahririan MA, Motififard M, Omidian A, Aghdam HA, Esmaeali A (2017) Relationship between bone mineral density and serum vitamin D with low energy hip and distal radius fractures: a case-control study. Arch Bone Jt Surg 5:22–27. https://doi.org/10.22038/abjs.2016.7936

    Article  PubMed  PubMed Central  Google Scholar 

  43. Dretakis K, Igoumenou VG (2019) The role of parathyroid hormone (PTH) and vitamin D in falls and hip fracture type. Aging Clin Exp Res 31:1501–1507. https://doi.org/10.1007/s40520-019-01132-7

    Article  PubMed  Google Scholar 

  44. Moo IH, Kam CJW, Cher EWL, Peh BCJ, Lo CE, Chua DTC, Lo NN, Howe TS, Koh JSB (2020) The effect of the comorbidity burden on vitamin D levels in geriatric hip fracture. BMC Musculoskelet Disord. https://doi.org/10.1186/s12891-020-03554-1

    Article  PubMed  PubMed Central  Google Scholar 

  45. Wang Q, Yu D, Wang J, Lin S (2020) Association between vitamin D deficiency and fragility fractures in Chinese elderly patients: a cross-sectional study. Ann Palliat Med 9:1660–1665. https://doi.org/10.21037/apm-19-610

    Article  PubMed  Google Scholar 

  46. Chiang MH, Kuo YJ, Chang WC, Wu Y, Lin YC, Jang YC, Chen YP (2021) Association of vitamin d deficiency with low serum albumin in Taiwanese older adults with hip fracture: a prospective cross-sectional study. J Nutr Sci Vitaminol 67:153–162. https://doi.org/10.3177/jnsv.67.153

    Article  CAS  PubMed  Google Scholar 

  47. Zhao J, Cai Q, Jiang D, Wang L, Chen S, Jia W (2020) The associations of serum vitamin d and bone turnover markers with the type and severity of hip fractures in older women. Clin Interv Aging 15:1971–1978. https://doi.org/10.2147/CIA.S271904

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Cauley JA, Parimi N, Ensrud KE, Bauer DC, Cawthon PM, Cummings SR, Hoffman AR, Shikany JM, Barrett-Connor E, Orwoll E (2010) Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. J Bone Miner Res 25:545–553. https://doi.org/10.1359/jbmr.090826

    Article  CAS  PubMed  Google Scholar 

  49. Holvik K, Ahmed LA, Forsmo S, Gjesdal CG, Grimnes G, Samuelsen SO, Schei B, Blomhoff R, Tell GS, Meyer HE (2013) Low serum levels of 25-hydroxyvitamin D predict hip fracture in the elderly: A NOREPOS study. J Clin Endocrinol Metab 98:3341–3350. https://doi.org/10.1210/jc.2013-1468

    Article  CAS  PubMed  Google Scholar 

  50. Swanson CM, Srikanth P, Lee CG, Cummings SR, Jans I, Cauley JA, Bouillon R, Vanderschueren D, Orwoll ES, Nielson CM (2015) Associations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with bone mineral density, bone mineral density change, and incident nonvertebral fracture (in eng). J Bone Miner Res 30:1403–1413. https://doi.org/10.1002/jbmr.2487

    Article  CAS  PubMed  Google Scholar 

  51. Ginsberg C, Katz R, de Boer IH, Kestenbaum BR, Chonchol M, Shlipak MG, Sarnak MJ, Hoofnagle AN, Rifkin DE, Garimella PS, Ix JH (2018) The 24,25 to 25-hydroxyvitamin D ratio and fracture risk in older adults: the cardiovascular health study (in eng). Bone 107:124–130. https://doi.org/10.1016/j.bone.2017.11.011

    Article  CAS  PubMed  Google Scholar 

  52. Cummings SR, Browner WS, Bauer D, Stone K, Ensrud K, Jamal S, Ettinger B (1998) Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of osteoporotic fractures research group (in eng). N Engl J Med 339:733–738. https://doi.org/10.1056/nejm199809103391104

    Article  CAS  PubMed  Google Scholar 

  53. Looker AC, Mussolino ME (2008) Serum 25-hydroxyvitamin D and hip fracture risk in older U.S. white adults. J Bone Miner Res 23:143–150. https://doi.org/10.1359/jbmr.071003

    Article  CAS  PubMed  Google Scholar 

  54. Bolland MJ, Bacon CJ, Horne AM, Mason BH, Ames RW, Wang TK, Grey AB, Gamble GD, Reid IR (2009) Vitamin D insufficiency and health outcomes over 5 y in older women. Am J Clin Nutr 91:82–89. https://doi.org/10.3945/ajcn.2009.28424

    Article  CAS  PubMed  Google Scholar 

  55. Chan R, Chan CC, Woo J, Ohlsson C, Mellström D, Kwok T, Leung PC (2011) Serum 25-hydroxyvitamin D, bone mineral density, and non-vertebral fracture risk in community-dwelling older men: results from Mr. Os, Hong Kong (in eng). Arch Osteoporos 6:21–30. https://doi.org/10.1007/s11657-011-0053-0

    Article  PubMed  Google Scholar 

  56. Robinson-Cohen C, Katz R, Hoofnagle AN, Cauley JA, Furberg CD, Robbins JA, Chen Z, Siscovick DS, de Boer IH, Kestenbaum B (2011) Mineral metabolism markers and the long-term risk of hip fracture: the cardiovascular health study. J Clin Endocrinol Metab 96:2186–2193. https://doi.org/10.1210/jc.2010-2878

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Barbour KE, Houston DK, Cummings SR, Boudreau R, Prasad T, Sheu Y, Bauer DC, Tooze JA, Kritchevsky SB, Tylavsky FA, Harris TB, Cauley JA (2012) Calciotropic hormones and the risk of hip and nonspine fractures in older adults: the health ABC study (in eng). J Bone Miner Res 27:1177–1185. https://doi.org/10.1002/jbmr.1545

    Article  CAS  PubMed  Google Scholar 

  58. de Boer IH, Levin G, Robinson-Cohen C, Biggs ML, Hoofnagle AN, Siscovick DS, Kestenbaum B (2012) Serum 25-hydroxyvitamin D concentration and risk for major clinical disease events in a community-based population of older adults a cohort study. Ann Int Med 156:627–634. https://doi.org/10.7326/0003-4819-156-9-201205010-00004

    Article  PubMed  Google Scholar 

  59. Rouzi AA, Al-Sibiani SA, Al-Senani NS, Radaddi RM, Ardawi MS (2012) Independent predictors of all osteoporosis-related fractures among healthy Saudi postmenopausal women: the CEOR Study (in eng). Bone 50:713–722. https://doi.org/10.1016/j.bone.2011.11.024

    Article  PubMed  Google Scholar 

  60. Kauppi M, Impivaara O, Maki J, Heliovaara M, Jula A (2013) Quantitative ultrasound measurements and vitamin D status in the assessment of hip fracture risk in a nationally representative population sample. Osteoporos Int 24:2611–2618. https://doi.org/10.1007/s00198-013-2355-0

    Article  CAS  PubMed  Google Scholar 

  61. Looker AC (2013) Serum 25-hydroxyvitamin D and risk of major osteoporotic fractures in older U.S. adults. J Bone Miner Res 28:997–1006. https://doi.org/10.1002/jbmr.1828

    Article  CAS  PubMed  Google Scholar 

  62. Buchebner D, McGuigan F, Gerdhem P, Malm J, Ridderstrale M, Akesson K (2014) Vitamin D insufficiency over 5 years is associated with increased fracture risk-an observational cohort study of elderly women. Osteoporos Int 25:2767–2775. https://doi.org/10.1007/s00198-014-2823-1

    Article  CAS  PubMed  Google Scholar 

  63. Snellman G, Byberg L, Lemming EW, Melhus H, Gedeborg R, Mallmin H, Wolk A, Michaelsson K (2014) Long-term dietary vitamin D intake and risk of fracture and osteoporosis: a longitudinal cohort study of Swedish middle-aged and elderly women. J Clin Endocrinol Metab 99:781–790. https://doi.org/10.1210/jc.2013-1738

    Article  CAS  PubMed  Google Scholar 

  64. Steingrimsdottir L, Halldorsson TI, Siggeirsdottir K, Cotch MF, Einarsdottir BO, Eiriksdottir G, Sigurdsson S, Launer LJ, Harris TB, Gudnason V, Sigurdsson G (2014) Hip fractures and bone mineral density in the elderly–importance of serum 25-hydroxyvitamin D (in eng). PLoS One 9:e91122. https://doi.org/10.1371/journal.pone.0091122

    Article  PubMed  PubMed Central  Google Scholar 

  65. Finnes TE, Lofthus CM, Meyer HE, Søgaard AJ, Tell GS, Apalset EM, Gjesdal C, Grimnes G, Schei B, Blomhoff R, Samuelsen SO, Holvik K (2016) A combination of low serum concentrations of vitamins K1 and D is associated with increased risk of hip fractures in elderly Norwegians: a NOREPOS study (in eng). Osteoporos Int 27:1645–1652. https://doi.org/10.1007/s00198-015-3435-0

    Article  CAS  PubMed  Google Scholar 

  66. Zhu K, Lewis JR, Sim M, Prince RL (2019) Low vitamin D status is associated with impaired bone quality and increased risk of fracture-related hospitalization in older Australian women (in eng). J Bone Miner Res 34:2019–2027. https://doi.org/10.1002/jbmr.3818

    Article  CAS  PubMed  Google Scholar 

  67. Diamond T, Smerdely P, Kormas N, Sekel R, Vu T, Day P (1998) Hip fracture in elderly men: the importance of subclinical vitamin D deficiency and hypogonadism. Med J Aust 169:138–141. https://doi.org/10.5694/j.1326-5377.1998.tb116014.x

    Article  CAS  PubMed  Google Scholar 

  68. Bakhtiyarova S, Lesnyak O, Kyznesova N, Blankenstein MA, Lips P (2006) Vitamin D status among patients with hip fracture and elderly control subjects in Yekaterinburg, Russia. Osteoporos Int 17:441–446. https://doi.org/10.1007/s00198-005-0006-9

    Article  CAS  PubMed  Google Scholar 

  69. Sakuma M, Endo N, Oinuma T, Hayami T, Endo E, Yazawa T, Watanabe K, Watanabe S (2006) Vitamin D and intact PTH status in patients with hip fracture. Osteoporos Int 17:1608–1614. https://doi.org/10.1007/s00198-006-0167-1

    Article  CAS  PubMed  Google Scholar 

  70. Cauley JA, LaCroix AZ, Wu L, Horwitz M, Danielson ME, Bauer DC, Lee JS, Jackson RD, Robbins JA, Wu C, Stanczyk FZ, LeBoff MS, Wactawski-Wende J, Sarto G, Ockene J, Cummings SR (2008) Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med 149:242–250. https://doi.org/10.7326/0003-4819-149-4-200808190-00005

    Article  PubMed  PubMed Central  Google Scholar 

  71. Nakano T, Tsugawa N, Kuwabara A, Kamao M, Tanaka K, Okano T (2011) High prevalence of hypovitaminosis D and K in patients with hip fracture (in eng). Asia Pac J Clin Nutr 20:56–61

    CAS  PubMed  Google Scholar 

  72. De Koning L, Henne D, Hemmelgarn BR, Woods P, Naugler C (2013) Non-linear relationship between serum 25-hydroxyvitamin D concentration and subsequent hip fracture. Osteoporos Int 24:2061–2065. https://doi.org/10.1007/s00198-012-2249-6

    Article  CAS  PubMed  Google Scholar 

  73. Fu XM, Fan SG, Li SL, Chen YS, Wu H, Guo YL (2015) Low 25(OH)D serum levels are related with hip fracture in postmenopausal women: a matched case-control study. J Transl Med. https://doi.org/10.1186/s12967-015-0756-x

    Article  PubMed  PubMed Central  Google Scholar 

  74. Zhuang HF, Wang PW, Li YZ, Lin JK, Yao XD, Xu H (2020) Analysis of related factors of brittle hip fracture in postmenopausal women with osteoporosis. Orthop Surg 12:194–198. https://doi.org/10.1111/os.12605

    Article  PubMed  PubMed Central  Google Scholar 

  75. Van Aert RC, Wicherts JM, Van Assen MA (2019) Publication bias examined in meta-analyses from psychology and medicine: a meta-meta-analysis. PLoS One 14:e0215052

    Article  Google Scholar 

  76. Lin L, Chu H (2018) Quantifying publication bias in meta-analysis. Biometrics 74:785–794

    Article  Google Scholar 

  77. Lv QB, Gao X, Liu X, Shao ZX, Xu QH, Tang L, Chi YL, Wu AM (2017) The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies (in eng). Oncotarget 8:39849–39858. https://doi.org/10.18632/oncotarget.16337

    Article  PubMed  PubMed Central  Google Scholar 

  78. Wang N, Chen Y, Ji J, Chang J, Yu S, Yu B (2020) The relationship between serum vitamin D and fracture risk in the elderly: a meta-analysis (in eng). J Orthop Res 15:81. https://doi.org/10.1186/s13018-020-01603-y

    Article  Google Scholar 

  79. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials (in eng). JAMA 293:2257–2264. https://doi.org/10.1001/jama.293.18.2257

    Article  CAS  PubMed  Google Scholar 

  80. Reid IR, Bolland MJ, Grey A (2014) Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis (in eng). Lancet (London, England) 383:146–155. https://doi.org/10.1016/s0140-6736(13)61647-5

    Article  CAS  Google Scholar 

  81. Ott SM (2018) Cortical or trabecular bone: what’s the difference? Am J Nephrol 47:373–375. https://doi.org/10.1159/000489672

    Article  PubMed  Google Scholar 

  82. Institute of Medicine (US) Standing committee on the scientific evaluation of dietary reference intakes. dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington (DC): National Academies Press (US); 1997. 4, Calcium. Available from: https://www.ncbi.nlm.nih.gov/books/NBK109827/.

  83. Levine MA (2012) Assessing bone health in children and adolescents (in eng). Indian J Endocrinol Metab 16:S205–S212. https://doi.org/10.4103/2230-8210.104040

    Article  PubMed  PubMed Central  Google Scholar 

  84. Pepa GD, Brandi ML (2016) Microelements for bone boost: the last but not the least (in eng). Clin Cases Miner Bone Metab 13:181–185. https://doi.org/10.11138/ccmbm/2016.13.3.181

    Article  PubMed  Google Scholar 

  85. Muñoz-Garach A, García-Fontana B, Muñoz-Torres M (2020) Nutrients and dietary patterns related to osteoporosis (in eng). Nutrients 12:1986. https://doi.org/10.3390/nu12071986

    Article  CAS  PubMed Central  Google Scholar 

  86. Price CT, Langford JR, Liporace FA (2012) Essential nutrients for bone health and a review of their availability in the average North American diet (in eng). Open Orthop J 6:143–149. https://doi.org/10.2174/1874325001206010143

    Article  PubMed  PubMed Central  Google Scholar 

  87. Najeeb S, Zafar MS, Khurshid Z, Zohaib S, Almas K (2016) The role of nutrition in periodontal health: an update (in eng). Nutrients 8:530. https://doi.org/10.3390/nu8090530

    Article  CAS  PubMed Central  Google Scholar 

  88. Alagawany M, Elnesr SS, Farag MR, Tiwari R, Yatoo MI, Karthik K, Michalak I, Dhama K (2020) Nutritional significance of amino acids, vitamins and minerals as nutraceuticals in poultry production and health - a comprehensive review (in eng). Vet Q 41:1–29. https://doi.org/10.1080/01652176.2020.1857887

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author notes

  1. Shahrzad Habibi Ghahfarrokhi, Abdollah Mohammadian-Hafshejani & Saeid Heidari-Soureshjani

    Present address: Deputy of Research and Technology Kashani Boulevard, Shahrekord University of Medical Sciences, Shahrekord, Iran

  2. Catherine M. T. Sherwin

    Present address: Dayton Children’s Hospital, 1 Childrens Plz, Dayton, OH, 45404-1873, USA

Authors and Affiliations

  1. Department of Social Medicine, Modeling in Health Research Center, Shahrekord University of Medical Sciences, Social Determinants of Health Research Center, Shahrekord, Iran

    Shahrzad Habibi Ghahfarrokhi

  2. Department of Epidemiology and Biostatistics, School of Public Health, Shahrekord University of Medical Sciences, Shahrekord, Iran

    Abdollah Mohammadian-Hafshejani

  3. Pediatric Clinical Pharmacology, Department of Pediatrics, Wright State University Boonshoft School of Medicine, Dayton Children’s Hospital, Dayton, OH, USA

    Catherine M. T. Sherwin

  4. Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

    Saeid Heidari-Soureshjani

  5. Circuit of Research and Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran

    Saeid Heidari-Soureshjani

Authors
  1. Shahrzad Habibi Ghahfarrokhi
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  2. Abdollah Mohammadian-Hafshejani
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  3. Catherine M. T. Sherwin
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Correspondence to Saeid Heidari-Soureshjani.

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Habibi Ghahfarrokhi, S., Mohammadian-Hafshejani, A., Sherwin, C.M.T. et al. Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis. J Bone Miner Metab 40, 541–553 (2022). https://doi.org/10.1007/s00774-022-01333-7

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  • DOI: https://doi.org/10.1007/s00774-022-01333-7

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