Abstract
Stoichiometry of analytical reactions is discussed as an important element of many primary methods (gravimetry, volumetry, spectrophotometry, etc.) and therefore, of chemical metrology as a whole. Variations in stoichiometry caused by non-equilibrium conditions, by changes in the reaction medium or by other factors can be a source of the dominant uncertainty component in the analytical measurement. Such a situation is illustrated with the Karl Fischer (KF) reaction which is widely used in aquametry. Two kinds of solvents used as a part of the reaction medium – alcohols and amides – are compared. The influence of the media on the stoichiometry of the reaction and, correspondingly, on the titre of the KF reagent is evaluated.
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Received: 4 November 1998 · Accepted: 22 December 1998
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Sherman, F., Kuselman, I. Stoichiometry and chemical metrology: Karl Fischer reaction. Accred Qual Assur 4, 230–234 (1999). https://doi.org/10.1007/s007690050357
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DOI: https://doi.org/10.1007/s007690050357