Abstract
Pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is a crucial regulator of nutrient metabolism and metabolic detoxification such as metabolic syndrome, xenobiotic metabolism, inflammatory responses, glucose, cholesterol and lipid metabolism, and endocrine homeostasis. Notably, much experimental and clinical evidence show that PXR senses xenobiotics and triggers the detoxification response to prevent diseases such as diabetes, obesity, intestinal inflammatory diseases and liver fibrosis. In this review we summarize recent advances on remarkable metabolic and regulatory versatility of PXR, and we emphasizes its role and potential implication as an effective modulator of self-detoxification in animals and humans.
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Acknowledgements
This study was supported by Hunan Outstanding Young Scholars Foundation (2016JJ1015), National Basic Research Program of China (2013CB127301, 2013CB127306), the National Natural Science Foundation Project (31472107), the Chinese Academy of Sciences “Hundred Talent” award, and the Open Foundation of Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences (ISA2016101), National Science and Technology Support Project (2013BAD21B04), and National Natural Science Foundation of China (31472106). Chinese Academy of Sciences visiting professorship for senior international scientists Grant (2016VBB007).
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He, L., Zhou, X., Huang, N. et al. Functions of pregnane X receptor in self-detoxification. Amino Acids 49, 1999–2007 (2017). https://doi.org/10.1007/s00726-017-2435-0
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DOI: https://doi.org/10.1007/s00726-017-2435-0