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Human interstitial cellular model in therapeutics of heart valve calcification

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Abstract

Calcific aortic valve disease is a common, severe heart condition that is currently with no proven, effective drug treatment and requires a surgical valve replacement or an entire heart explanation. Thus, developing novel, targeted therapeutic approaches becomes a major goal for cardiovascular disease research. To achieve this goal, isolated heart valve interstitial cells could be an advanced model to explore molecular mechanisms and measure drug efficacy. Based on this progress, molecular mechanisms that harbor components of  inflammation and fibrosis coupled with proteins, for example, BMP-2, TLRs, RANKL, Osteoprotegerin, have been proposed. Small molecules or antibodies targeting these proteins have shown promising efficacy for either reversing or slowing down calcification development in vitro. In this review, we summarize these potential therapeutics with some highlights of interstitial cellular models.

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Acknowledgements

This project was supported by the National Innovation Student Program (201430191040) to H.T., Z. M., N. L., Z. Z., the National Key Research and Development Program of China (2016YFD0501201) to Y. Y. and X. Y., Open Fund of National Laboratory of Subtropical Agriculture Ecology Process, Chinese Academy of Sciences (ISA2016204), and Xiaoxiang Endowed University Professor Fund of Hunan Normal University (No. 840140-008) to X.Y, Chinese Academy of Sciences Visiting Professorship for Senior International Scientists Grant (no. 2016VBB007) to C. A. H.

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  1. Department of Pharmacy, School of Medicine, Hunan Normal University, Changsha, 410013, Hunan, People’s Republic of China

    Caimei He, Kwame Oteng Darko & Xiaoping Yang

  2. Animal Nutrition and Human Health Laboratory, College of Life Sciences, Hunan Normal University, Changsha, 410013, Hunan, People’s Republic of China

    Caimei He, Yulong Yin, Chien-An Andy Hu & Xiaoping Yang

  3. Department of Clinic Medicine, School of Medicine, Hunan Normal University, Changsha, 410013, Hunan, People’s Republic of China

    Hai Tang, Zijian Mei, Nichujie Li & Zhi Zeng

  4. Institute of Subtropical Agriculture, Research Center for Healthy Breeding of Livestock and Poultry, Hunan Engineering and Research Center of Animal and Poultry Science and Key Laboratory for Agroecological Processes in Subtropical Region, Scientific Observation and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Chinese Academy of Science, Changsha, 410125, People’s Republic of China

    Yulong Yin, Chien-An Andy Hu & Xiaoping Yang

  5. Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine and Health Sciences Center, MSC 08 4670, Fitz 258, 915 Camino de Salud, Albuquerque, NM, 87131-0001, USA

    Chien-An Andy Hu

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  1. Caimei He
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  9. Xiaoping Yang
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Correspondence to Yulong Yin, Chien-An Andy Hu or Xiaoping Yang.

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This review does not involve any human participants and animal work.

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Handling Editors: C.-A.A. Hu, Y. Yin, Y. Hou, G. Wu, Y. Teng.

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He, C., Tang, H., Mei, Z. et al. Human interstitial cellular model in therapeutics of heart valve calcification. Amino Acids 49, 1981–1997 (2017). https://doi.org/10.1007/s00726-017-2432-3

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