Abstract
We synthesized in a few steps both diastereomers of orthogonally protected β,γ-diamino acids starting from l-phenylalanine or l-tryptophan. These final compounds are interesting building blocks for peptide synthesis and foldamer chemistry. The key step is a Blaise reaction performed under ultrasound conditions.
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This research was supported by the M.E.S.R. (Doctoral Grant to A.S.).
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Auberger, N., Stanovych, A., Thétiot-Laurent, S. et al. Efficient synthesis of both diastereomers of β,γ-diamino acids from phenylalanine and tryptophan. Amino Acids 48, 2237–2242 (2016). https://doi.org/10.1007/s00726-016-2262-8
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DOI: https://doi.org/10.1007/s00726-016-2262-8