Abstract
A triple four-component Ugi reaction of isocyanide, amine, aldehyde, and trimesic acid as the acid component with three acidic functional groups in MeOH at 65 °C has been disclosed. The process employs readily available and low-cost reagents, a convenient synthetic procedure, and mild reaction conditions for the synthesis of pharmacologically significant and structurally interesting compounds with several peptide groups, suitable for dendrimers and self-assembling. Substituents could be independently varied at three different positions. The structural assignments are supported by 1H and 13C NMR data.
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We gratefully acknowledge financial support from the Research Council of Shahrood University of Technology and Babol Noshirvani University of Technology.
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Dehghan, N., Nasr-Isfahani, H., Sarvary, A. et al. Trimesic acid is a suitable building block in triple four-component Ugi reaction: access to unique trivalent compounds. Monatsh Chem 151, 397–404 (2020). https://doi.org/10.1007/s00706-020-02554-0
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DOI: https://doi.org/10.1007/s00706-020-02554-0