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Cerebral perfusion abnormalities in patients with persistent postural-perceptual dizziness (PPPD): a SPECT study

  • Neurology and Preclinical Neurological Studies - Original Article
  • Published:
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A Correction to this article was published on 07 February 2019

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Abstract

Persistent postural-perceptual dizziness (PPPD) is a recently defined syndrome with chronic dizziness interrupting daily life. Although the high levels of anxiety and functional changes in postural control strategy and multi-sensory information processing and integration may be underlying the pathophysiology, its neural mechanisms are poorly understood. The aim of this study was to examine the regional cerebral blood flow (rCBF) in patients with PPPD using single photon emission computed tomography (SPECT). A total of 25 patients with PPPD and 25 healthy controls participated in the study. All participants underwent brain SPECT and the patients completed the Dizziness Handicap Inventory. SPECT images were compared between the groups, and the correlation of rCBF and disease severity/duration was assessed in patients. Compared with controls, PPPD patients showed a significantly decreased rCBF in the insula and frontal lobe, mainly in the left posterior insula, bilateral superior frontal gyrus, right inferior frontal gyrus, right precentral gyrus, and left medial orbital gyrus. Additionally, PPPD patients showed a significant rCBF increase in the bilateral cerebellum compared with controls. The results of our study suggest that the altered rCBF in the insular, frontal, and cerebellar cortices might be reflecting the process of maladaptation and the compensatory responses for the changes in PPPD.

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Change history

  • 07 February 2019

    The authors inadvertently forgot to provide the following funding information in the original publication: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT (2018R1A6A3A11041118).

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Seunghee Na & In-Uk Song

  2. Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Jooyeon Jamie Im, Hyeonseok Jeong & Yong-An Chung

  3. Department of Neurology, Soonchunhyang University College of Medicine, Bucheon, South Korea

    Eek-Sung Lee & Tae-Kyeong Lee

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  1. Seunghee Na
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  2. Jooyeon Jamie Im
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  3. Hyeonseok Jeong
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  4. Eek-Sung Lee
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  7. In-Uk Song
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Correspondence to Yong-An Chung or In-Uk Song.

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Na, S., Im, J.J., Jeong, H. et al. Cerebral perfusion abnormalities in patients with persistent postural-perceptual dizziness (PPPD): a SPECT study. J Neural Transm 126, 123–129 (2019). https://doi.org/10.1007/s00702-018-1948-3

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  • DOI: https://doi.org/10.1007/s00702-018-1948-3

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