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Effect of serum uric acid on cognition in patients with idiopathic REM sleep behavior disorder

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

Idiopathic rapid eye movement sleep behavior disorder (iRBD) likely represents the prodromal stage of synucleinopathy. The present study investigated how levels of serum uric acid (UA) affect cognition and motor function in patients with iRBD. A total of 42 patients with iRBD and 45 healthy controls were included. All participants were given cognitive tests and motor assessments. Serum UA concentrations were measured. The patients were further divided into two groups (high or low UA) according to serum UA level. The level of serum UA was similar between the patients with iRBD and the healthy controls, whereas the patients showed impaired executive, memory, and visuospatial functions. The patients with low UA levels had longer durations of RBD. Lower scores involving attention, executive function, and language domain were also found in the patients with low UA, whereas the scores of the patients with high UA were similar to those of the healthy controls. Regarding memory domain, the low UA group had worse scores than the healthy controls, whereas the scores of high UA group fell between those of the low UA group and the healthy controls. Motor function was not affected in any of the groups. UA affects cognitive function but not motor function in patients with iRBD, which could contribute to its antioxidant and neuroprotective roles.

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Acknowledgements

The authors thank all the participating investigators. The study was supported by the China-Japan Friendship Hospital (2014-4-QN-32).

Funding

Funding was provided by China-Japan Friendship Hospital (Grant no. 30000RMB).

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Authors and Affiliations

  1. Department of Cognitive Disorder, Beijing Tiantan Hospital, Capital Medical University, Dongcheng District, Beijing Tiantan Xili the 6th, Beijing, 100050, China

    Xudong Li

  2. China National Clinical Research Center for Neurological Diseases, Beijing, China

    Xudong Li

  3. Department of Neurology, China-Japan Friendship Hospital, Beijing, China

    Shuhong Jia, Yi Jin, Xiangfei Zhang, Chunlei Hou, Wenjing Zheng, Pei Rong & Jinsong Jiao

  4. Department of Senior Official Ward, China-Japan Friendship Hospital, Beijing, China

    Zhi Zhou

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  1. Xudong Li
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Correspondence to Xudong Li.

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Li, X., Jia, S., Zhou, Z. et al. Effect of serum uric acid on cognition in patients with idiopathic REM sleep behavior disorder. J Neural Transm 125, 1805–1812 (2018). https://doi.org/10.1007/s00702-018-1935-8

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  • DOI: https://doi.org/10.1007/s00702-018-1935-8

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