Abstract
Purpose
Several factors are known to be significantly associated with a low completion rate of 1-year adjuvant S-1 monotherapy for gastric cancer. The present study investigated whether or not the specialties of physicians conducting adjuvant S-1 monotherapy affect the completion rate.
Methods
A total of 437 patients who underwent curative gastrectomy followed by adjuvant S-1 monotherapy for pathological stage II or III gastric cancer between 2008 and 2013 were retrospectively analyzed. Factors affecting completion of adjuvant S-1 monotherapy, including the physicians (medical oncologists or surgeons) administering S-1, were evaluated by a multivariate analysis. The relationship between patient factors and physicians was analyzed regarding the cumulative incidence of discontinuation. The number of times the dose was reduced, the schedule changed, or administration was suspended or delayed in patients completing adjuvant S-1 monotherapy was also counted.
Results
The multivariate analysis showed that old age (≥ 65 years old), excess body weight loss (≥ 15%), and surgeons were independently associated with discontinuation. In older patients, the cumulative incidence of discontinuation by medical oncologists was significantly lower than that by surgeons. Medical oncologists ensured that older patients continued S-1 by frequent suspension or a delay in each course.
Conclusions
Medical oncologists may facilitate completion of adjuvant S-1 monotherapy.
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References
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Takeshi Sano received honoraria from Taiho Pharmaceutical, Chugai Pharmaceutical, Ono Pharmaceutical, MSD and Eli Lilly; Kensei Yamaguchi received honoraria from Takeda Pharmaceutical Company Limited, Bayer, Daiichi-Sankyo, Sanofi, Dainippon-Sumitomo, MSD and Gilead and received research finding from Taiho Pharmaceutical, Eli Lilly, Ono Pharmaceutical, Bristol-Myers Squibb, Yakult and Chugai Pharmaceutical; Daisuke Takahari received honoraria from Eli Lilly, Brustol-Myers Squibb, Yakult and Chugai Pharmaceutical, and received research finding from Taiho Pharmaceutical and Ono Pharmaceutical.
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Kano, Y., Ohashi, M., Hiki, N. et al. Facilitated completion of 1-year adjuvant S-1 monotherapy for pathological stage II or III gastric cancer by medical oncologists. Surg Today 50, 1197–1205 (2020). https://doi.org/10.1007/s00595-020-01995-8
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DOI: https://doi.org/10.1007/s00595-020-01995-8