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Granular Cell Tumor of the Breast Preoperatively Diagnosed by Fine-Needle Aspiration Cytology: Report of a Case

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Abstract

Granular cell tumors (GCTs) have a characteristic cytological appearance, and fine-needle aspiration cytology (FNAC) has been suggested to be the diagnostic modality of choice. However, the differential diagnosis has not yet been well described. We herein describe a rare case of GCT of the breast and discuss the differential diagnosis. A 53-year-old woman presented to our hospital with a left breast mass. In clinical and radiological examinations, the mass was suspected to be malignant. Cytologically, the tumor was composed of cohesive groups of cells with a syncytial appearance, and the cells contained abundant, finely eosinophilic cytoplasmic granules and small round-to-slightly-oval nuclei, thus suggesting the presence of benign GCT. The results of immunohistochemical staining supported the proposed deviation from Schwann cells. This case emphasizes the fact that GCTs are a rare but important possibility in the differential diagnosis of breast tumors, and that FNAC may provide clinically useful information on the management of such lesions.

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Akatsu, T., Kobayashi, H., Uematsu, S. et al. Granular Cell Tumor of the Breast Preoperatively Diagnosed by Fine-Needle Aspiration Cytology: Report of a Case. Surg Today 34, 760–763 (2004). https://doi.org/10.1007/s00595-004-2784-7

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  • DOI: https://doi.org/10.1007/s00595-004-2784-7

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