Abstract
Aims
Identifying women at high risk of developing gestational diabetes mellitus (GDM) is a public health interest. This study aims to investigate the association between maternal height and risk of GDM through meta-analysis.
Methods
We retrieved the studies that assessed maternal height in relation to GDM. Pooled risk estimates of the included articles and their 95% confidence intervals (95% CIs) were calculated using a fixed- or random-effects model. Subgroup analyses were conducted according to study design and study location. Quality of studies was determined using the Newcastle–Ottawa Scale. Publication bias was detected using the Egger’s and Begg’s tests.
Results
A total of 10 studies including 7 cohort and 3 cross-sectional studies with a total of 126,094 women were included for meta-analysis. Combined, each 5-cm increase in height was associated with about 20% reduction in risk of GDM [pooled odds ratio = 0.80, (95% CI 0.76, 0.85)]. The analysis revealed high heterogeneity between studies which dissolved after subgroup analysis by study design. This significant association did not differ between Asian and non-Asian populations. Egger’s and Begg’s tests showed little evidence of publication bias.
Conclusions
The present meta-analysis supports the conception that short stature is associated with GDM. Further studies of high quality are needed to confirm the findings.
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References
Kampmann U, Madsen LR, Skajaa GO, Iversen DS, Moeller N, Ovesen P (2015) Gestational diabetes: a clinical update. World J Diabetes 6(8):1065–1072. https://doi.org/10.4239/wjd.v6.i8.1065
Buchanan TA, Xiang AH, Page KA (2012) Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol 8(11):639–649. https://doi.org/10.1038/nrendo.2012.96
Bellamy L, Casas JP, Hingorani AD, Williams D (2009) Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet (London, England) 373(9677):1773–1779. https://doi.org/10.1016/s0140-6736(09)60731-5
Li J, Song C, Li C, Liu P, Sun Z, Yang X (2018) Increased risk of cardiovascular disease in women with prior gestational diabetes: A systematic review and meta-analysis. Diabetes Res Clin Pract 140:324–338. https://doi.org/10.1016/j.diabres.2018.03.054
McKenzie-Sampson S, Paradis G, Healy-Profitos J, St-Pierre F, Auger N (2018) Gestational diabetes and risk of cardiovascular disease up to 25 years after pregnancy: a retrospective cohort study. Acta Diabetol 55(4):315–322. https://doi.org/10.1007/s00592-017-1099-2
Boerschmann H, Pfluger M, Henneberger L, Ziegler AG, Hummel S (2010) Prevalence and predictors of overweight and insulin resistance in offspring of mothers with gestational diabetes mellitus. Diabetes Care 33(8):1845–1849. https://doi.org/10.2337/dc10-0139
Maftei O, Whitrow MJ, Davies MJ, Giles LC, Owens JA, Moore VM (2015) Maternal body size prior to pregnancy, gestational diabetes and weight gain: associations with insulin resistance in children at 9-10 years. Diabetic Med 32(2):174–180. https://doi.org/10.1111/dme.12637
Ali AD, Mehrass AA, Al-Adhroey AH, Al-Shammakh AA, Amran AA (2016) Prevalence and risk factors of gestational diabetes mellitus in Yemen. Int J women’s Health 8:35–41. https://doi.org/10.2147/ijwh.s97502
Anastasiou E, Alevizaki M, Grigorakis SJ, Philippou G, Kyprianou M, Souvatzoglou A (1998) Decreased stature in gestational diabetes mellitus. Diabetologia 41(9):997–1001. https://doi.org/10.1007/s001250051022
Jang HC, Min HK, Lee HK, Cho NH, Metzger BE (1998) Short stature in Korean women: a contribution to the multifactorial predisposition to gestational diabetes mellitus. Diabetologia 41(7):778–783. https://doi.org/10.1007/s001250050987
Branchtein L, Schmidt MI, Matos MC, Yamashita T, Pousada JM, Duncan BB (2000) Short stature and gestational diabetes in Brazil. Brazilian Gestational Diabetes Study Group. Diabetologia 43(7):848–851
Yang X, Hsu-Hage B, Zhang H et al (2002) Gestational diabetes mellitus in women of single gravidity in Tianjin City, China. Diabetes Care 25(5):847–851
Rudra CB, Sorensen TK, Leisenring WM, Dashow E, Williams MA (2007) Weight characteristics and height in relation to risk of gestational diabetes mellitus. Am J Epidemiol 165(3):302–308. https://doi.org/10.1093/aje/kwk007
Ogonowski J, Miazgowski T (2010) Are short women at risk for gestational diabetes mellitus? Eur J Endocrinol 162(3):491–497. https://doi.org/10.1530/eje-09-0992
Brite J, Shiroma EJ, Bowers K, Yeung E, Laughon SK, Grewal JG, Zhang C (2014) Height and the risk of gestational diabetes: variations by race/ethnicity. Diabetic Med 31(3):332–340. https://doi.org/10.1111/dme.12355
Syngelaki A, Pastides A, Kotecha R, Wright A, Akolekar R, Nicolaides KH (2015) First-trimester screening for gestational diabetes mellitus based on maternal characteristics and history. Fetal Diagn Therapy 38(1):14–21. https://doi.org/10.1159/000369970
Li H, Song L, Shen L et al (2018) Height and risk of gestational diabetes mellitus: results from the healthy baby cohort study. J Diabetes Res 2018:4679245. https://doi.org/10.1155/2018/4679245
Li J, Wang P, Zhang C et al (2018) Short body height and pre-pregnancy overweight for increased risk of gestational diabetes mellitus: a population-based cohort study. Front Endocrinol 9:349. https://doi.org/10.3389/fendo.2018.00349
Mendoza LC, Harreiter J, Simmons D et al (2018) Risk factors for hyperglycemia in pregnancy in the DALI study differ by period of pregnancy and OGTT time point. Eur J Endocrinol 179(1):39–49. https://doi.org/10.1530/eje-18-0003
Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 283(15):2008–2012
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ (Clinical research ed) 339:b2535. https://doi.org/10.1136/bmj.b2535
Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ (Clinical research ed) 327(7414):557–560. https://doi.org/10.1136/bmj.327.7414.557
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188
Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088–1101
Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical research ed) 315(7109):629–634
Janghorbani M, Momeni F, Dehghani M (2012) Hip circumference, height and risk of type 2 diabetes: systematic review and meta-analysis. Obes Rev 13(12):1172–1181. https://doi.org/10.1111/j.1467-789X.2012.01030.x
Nuesch E, Dale C, Palmer TM et al (2016) Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. Int J Epidemiol 45(6):1927–1937. https://doi.org/10.1093/ije/dyv074
Zhou W, Li Y, Liu X et al (2019) Sex-specific relationship between adult height and the risk of stroke: a dose–response meta-analysis of prospective studies. J Clin Hypertens (Greenwich, Conn) 21(2):262–270. https://doi.org/10.1111/jch.13458
Yeung EH, Hu FB, Solomon CG et al (2010) Life-course weight characteristics and the risk of gestational diabetes. Diabetologia 53(4):668–678. https://doi.org/10.1007/s00125-009-1634-y
Wang Z, Rowley K, Wang Z, Piers L, O’Dea K (2007) Anthropometric indices and their relationship with diabetes, hypertension and dyslipidemia in Australian Aboriginal people and Torres Strait Islanders. Eur J Cardiovasc Prev Rehabil 14(2):172–178. https://doi.org/10.1097/01.hjr.0000220580.34763.fb
Barros AJ, Victora CG, Horta BL, Goncalves HD, Lima RC, Lynch J (2006) Effects of socioeconomic change from birth to early adulthood on height and overweight. Int J Epidemiol 35(5):1233–1238. https://doi.org/10.1093/ije/dyl160
Tsenkova V, Pudrovska T, Karlamangla A (2014) Childhood socioeconomic disadvantage and prediabetes and diabetes in later life: a study of biopsychosocial pathways. Psychosom Med 76(8):622–628. https://doi.org/10.1097/psy.0000000000000106
Asao K, Kao WH, Baptiste-Roberts K, Bandeen-Roche K, Erlinger TP, Brancati FL (2006) Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994. Diabetes Care 29(7):1632–1637. https://doi.org/10.2337/dc05-1997
Bosy-Westphal A, Plachta-Danielzik S, Dorhofer RP, Muller MJ (2009) Short stature and obesity: positive association in adults but inverse association in children and adolescents. Br J Nutr 102(3):453–461. https://doi.org/10.1017/S0007114508190304
Vaessen N, Heutink P, Janssen JA et al (2001) A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction. Diabetes 50(3):637–642
Funding
This work was partly supported by Japan Society for the Promotion of Science KAKENHI Grant Numbers A18H063910 and T19K214700. Role of the Funder: The funder had no role in the conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript findings.
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AA collected the data, analyzed the data, and wrote the manuscript. JYD designed the study, collected the data, analyzed the data, conducted the technique review, and reviewed and edited the manuscript. JYD is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
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Arafa, A., Dong, JY. Maternal height and risk of gestational diabetes: a systematic review and meta-analysis. Acta Diabetol 56, 723–728 (2019). https://doi.org/10.1007/s00592-019-01368-9
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DOI: https://doi.org/10.1007/s00592-019-01368-9