Skip to main content

Advertisement

Log in

Impact of variations in duodenal glucose load on insulin clearance in health and type 2 diabetes

  • Short Communication
  • Published:
Acta Diabetologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Meier JJ, Holst JJ, Schmidt WE, Nauck MA (2007) Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans. Am J Physiol Endocrinol Metab 293:E849–E856

    Article  CAS  PubMed  Google Scholar 

  2. Shuster LT, Go VL, Rizza RA, O’Brien PC, Service FJ (1988) Incretin effect due to increased secretion and decreased clearance of insulin in normal humans. Diabetes 37:200–203

    Article  CAS  PubMed  Google Scholar 

  3. Horowitz M, Maddox AF, Wishart JM, Harding PE, Chatterton BE, Shearman DJ (1991) Relationships between oesophageal transit and solid and liquid gastric emptying in diabetes mellitus. Eur J Nucl Med 18:229–234

    Article  CAS  PubMed  Google Scholar 

  4. Marathe CS, Rayner CK, Jones KL, Horowitz M (2013) Relationships between gastric emptying, postprandial glycemia, and incretin hormones. Diabetes Care 36:1396–1405

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Marathe CS, Rayner CK, Bound M et al (2014) Small intestinal glucose exposure determines the magnitude of the incretin effect in health and type 2 diabetes. Diabetes 63:2668–2675

    Article  CAS  PubMed  Google Scholar 

  6. Ahren B, Thomaseth K, Pacini G (2005) Reduced insulin clearance contributes to the increased insulin levels after administration of glucagon-like peptide 1 in mice. Diabetologia 48:2140–2146

    Article  CAS  PubMed  Google Scholar 

  7. Lee CC, Haffner SM, Wagenknecht LE et al (2013) Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. Diabetes Care 36:901–907

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Goodarzi MO, Langefeld CD, Xiang AH et al (2014) Insulin sensitivity and insulin clearance are heritable and have strong genetic correlation in Mexican Americans. Obesity (Silver Spring) 22:1157–1164

    Article  CAS  PubMed Central  Google Scholar 

  9. Guo X, Cui J, Jones MR et al (2012) Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis. Diabetologia 55:2183–2192

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Valera Mora ME, Scarfone A, Calvani M, Greco AV, Mingrone G (2003) Insulin clearance in obesity. J Am Coll Nutr 22:487–493

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

Funding was provided by the National Health and Medical Research Council, Australia (Grant No. 627139).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chinmay S. Marathe.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Managed by Antonio Secchi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Marathe, C.S., Rayner, C.K., Jones, K.L. et al. Impact of variations in duodenal glucose load on insulin clearance in health and type 2 diabetes. Acta Diabetol 55, 205–207 (2018). https://doi.org/10.1007/s00592-017-1073-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00592-017-1073-z

Keywords

Navigation