Abstract
Purpose
This study aimed to investigate the diagnostic value of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the diffusion tensor imaging (DTI) with fiber tracking in patients with compressed lumbosacral nerve roots.
Methods
A systematic literature search of databases (PubMed, Embase, Cochrane Library, and Web of Science) was carried out. FA values and ADC values were compared between compressed nerve roots and healthy controls. Pooled and subgroup analyses were performed using fixed or random-effect models based on I2 heterogeneity.
Results
A total of 262 patients from ten studies with 285 compressed lumbosacral nerve roots and 285 contralateral normal nerve roots were included in the meta-analysis. It was showed in pooled results that FA value was significantly reduced (SMD − 3.03, 95% CI [ − 3.75 to − 2.31], P < 0.001) and ADC value was significantly increased (SMD 2.07, 95% CI [0.92 to 3.22], P < 0.001) in the compressed nerve roots, compared with contralateral normal nerve roots. Subgroup analysis comparing the FA values and ADC values in different nerve root ranges (L2–S1, L4–S1, L5–S1, L5, S1) revealed the different ranges of nerve roots were possible sources of heterogeneity.
Conclusions
This study showed that FA value reduction and ADC value increase were valuable indicators of compressed lumbosacral nerve roots. These changes may be related to the neurological symptoms of patients. DTI with fiber tracking can directly visualize and accurately locate the compression zone of nerve roots to help make surgical treatment plans, is more advanced than conventional MRI.
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References
Jensen RK, Jensen TS, Koes B, Hartvigsen J (2020) Prevalence of lumbar spinal stenosis in general and clinical populations: a systematic review and meta-analysis. Eur Spine J. https://doi.org/10.1007/s00586-020-06339-1
Kreiner DS, Hwang SW, Easa JE, Resnick DK, Baisden JL, Bess S et al (2014) An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy. Spine J 14:180–191
Brayda-Bruno M, Tibiletti M, Ito K, Fairbank J, Galbusera F, Zerbi A et al (2014) Advances in the diagnosis of degenerated lumbar discs and their possible clinical application. Eur Spine J 23:315–323
Oikawa Y, Eguchi Y, Inoue G, Yamauchi K, Orita S, Kamoda H (2015) Diffusion tensor imaging of lumbar spinal nerve in subjects with degenerative lumbar disorders. Magn Reson Imag 33:956–961
Liang KN, Feng PY, Feng XR, Cheng H (2019) Diffusion tensor imaging and fiber tractography reveal significant microstructural changes of cervical nerve roots in patients with cervical spondylotic radiculopathy. World Neurosurg 126:57–64
Cauley KA, Filippi CG (2013) Diffusion-tensor imaging of small nerve bundles: cranial nerves, peripheral nerves, distal spinal cord, and lumbar nerve roots–clinical applications. AJNR Am J Roentgenol 201:326–335
Takagi T, Nakamura M, Yamada M, Hikishima K, Momoshima S, Fujiyoshi K et al (2009) Visualization of peripheral nerve degeneration and regeneration: monitoring with diffusion tensor tractography. Neuroimage 44:884–892
Gasparotti R, Lodoli G, Meoded A, Carletti F, Garozzo D, Ferraresi S (2013) Feasibility of diffusion tensor tractography of brachial plexus injuries at 1.5 T. Invest Radiol 48:104–112
Hendrix P, Griessenauer CJ, Cohen-Adad J, Rajasekaran S, Cauley KA, Shoja MM et al (2015) Spinal diffusion tensor imaging: a comprehensive review with emphasis on spinal cord anatomy and clinical applications. Clin Anat 28:88–95
Zhang J, Zhang F, Xiao F, Xiong Z, Liu D, Hua T et al (2018) Quantitative evaluation of the compressed L5 and S1 nerve roots in unilateral lumbar disc herniation by using diffusion tensor imaging. Clin Neuroradiol 28:529–537
He A, Wang WZ, Qiao PF, Qiao GY, Cheng H, Feng PY (2018) Quantitative evaluation of compressed L4–5 and S1 nerve roots of lumbar disc herniation patients by diffusion tensor imaging and fiber tractography. World Neurosurg 115:45–52
Eguchi Y, Oikawa Y, Suzuki M, Orita S, Yamauchi K, Suzuki M et al (2016) Diffusion tensor imaging of radiculopathy in patients with lumbar disc herniation: preliminary results. Bone Joint J 98:387–394
Li CT, Wang QZ, Xiao WF, Hui YY, Zhao B (2014) 3.0T MRI tractography of lumbar nerve roots in disc herniation. Acta Radiol 55:969–975
Balbi V, Budzik JF, Duhamel A, Bera-Louville A, Thuc VL, Cotten A (2011) Tractography of lumbar nerve roots: initial results. Eur Radiol 21:1153–1159
Wu W, Liang J, Ru N, Zhou C, Chen J, Wu Y et al (2016) Microstructural changes in compressed nerve roots are consistent with clinical symptoms and symptom duration in patients with lumbar disc herniation. Spine 41:661–666
Wu W, Liang J, Chen Y, Chen A, Wu B, Yang Z (2016) Microstructural changes in compressed nerve roots treated by percutaneous transforaminal endoscopic discectomy in patients with lumbar disc herniation. Med 95:e5106
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8:336–341
Wright JG, Swiontkowski MF, Heckman JD (2003) Introducing levels of evidence to the journal. J Bone Joint Surg Am 85:1–3
Wells G, Shea B, O’Connell D, Robertson J, Peterson J, Welch V et al (2000) The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses
Guan X, Fan G, Wu X, Gu G, Gu X, Zhang H et al (2015) Diffusion tensor imaging studies of cervical spondylotic myelopathy: a systemic review and meta-analysis. PLoS ONE 10:e0117707
Aoki Y, Inokuchi R, Gunshin M, Yahagi N, Suwa H (2012) Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis. J Neurol Neurosurg Psychiatry 83:870–876
Shi Y, Zou Y, Feng Y, Dou W, Ding H, Wang C et al (2020) A quantitative and clinical evaluation of nerve roots in lumbosacral radiculopathy using diffusion tensor imaging. Jpn J Radiol 38:222–230
Li JQ, Cui H, Liu ZP, Sun YP, Zhang F, Sun YC et al (2019) Utility of diffusion tensor imaging for guiding the treatment of lumbar disc herniation by percutaneous transforaminal endoscopic discectomy. Sci Rep 9:187532019
Wang XD, Wang HL, Sun C, Zhou SY, Meng T, Lv FZ et al (2019) Analysis of radiological parameters associated with decreased fractional anisotropy values on diffusion tensor imaging in patients with lumbar spinal stenosis. Eur Spine J 28:1397–1405
Li XF, Yang Y, Lin CB, Xie FR, Liang WG (2016) Assessment of the diagnostic value of diffusion tensor imaging in patients with spinal cord compression: a meta-analysis. Braz J Med Biol Res 49:e4769
Li JF, Wang YH, Wang YY, Lv Y, Ma L (2016) Study on lumbosacral nerve root compression using DTI. Biomed Rep 5:353–356
Eguchi Y, Ohtori S, Orita S, Kamoda H, Arai G, Ishikawa T et al (2011) Quantitative evaluation and visualization of lumbar foraminal nerve root entrapment by using diffusion tensor imaging: preliminary results. AJNR Am J Neuroradiol 32:1824–1829
Toh E, Mochida J (1997) Histologic analysis of the lumbosacral nerve roots after compression in young and aged rabbits. Spine 22:721–726
Suzuki K, Takatsu T, Inoue H, Teramoto T, Ishida Y, Ohmori K (1992) Redundant nerve roots of the cauda equina caused by lumbar spinal canal stenosis. Spine 17:1337–1342
Wu W, Niu Y, Kong X, Liu D, Long X, Shu S et al (2018) Application of diffusion tensor imaging in quantitatively monitoring chronic constriction injury of rabbit sciatic nerves: correlation with histological and functional changes. Br J Radiol 91:20170414
Lehmann HC, Zhang J, Mori S, Sheikh KA (2010) Diffusion tensor imaging to assess axonal regeneration in peripheral nerves. Exp Neurol 223:238–244
Wu W, Liang J, Chen Y, Chen A, Wu Y, Yang Z (2017) Microstructural changes are coincident with the improvement of clinical symptoms in surgically treated compressed nerve roots. Sci Rep 7:44678
Eguchi Y, Ohtori S, Suzuki M, Oikawa Y, Yamanaka H, Tamai H et al (2016) Discrimination between lumbar intraspinal stenosis and foraminal stenosis using diffusion tensor imaging parameters: preliminary results. Asian Spine J 10:327–334
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This work was supported by the National Natural Science Foundation of China (No. 8167090209).
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All authors contributed to the review conception and design. Material preparation, data collection and analysis were performed by YH, WSL, and BH. The first draft of the manuscript was written by WSL and the work was critically revised by BH and YH. All authors commented on previous versions of the manuscript, as well as, read and approved the final manuscript.
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Weishi Liang and Bo Han contribute equally to this work, and they are the co-first authors.
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Liang, W., Han, B., Hai, Y. et al. Diffusion tensor imaging with fiber tracking provides a valuable quantitative and clinical evaluation for compressed lumbosacral nerve roots: a systematic review and meta-analysis. Eur Spine J 30, 818–828 (2021). https://doi.org/10.1007/s00586-020-06556-8
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DOI: https://doi.org/10.1007/s00586-020-06556-8