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RETRACTED ARTICLE: Prevalence of the C282Y and H63D mutations of the HFE hemochromatosis gene in Azerian major β-thalassemia and iron overload

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This article was retracted on 04 November 2016

Abstract

In this study, we have determined the allele frequency of HFE mutations H63D and C282Y in a group of Azerian beta-thalassemia major patients. These two mutations are implicated in hereditary hemochromatosis among Caucasians. In this study, we wanted to outbreak these mutations with the iron status in major beta-thalassemia patients. Sixty Azerian major beta-thalassemias were screening for the C282Y and H63D by digestion of polymerase chain reaction products (PCRP). Serum ferritin level was measured by enzyme-linked immunosorbent assay (ELISA). The allele frequency of H63D mutation was 20 %. C282Y mutation was not present in our studied patients. No statistically significant difference of serum ferritin level was found between major beta-thalassemia with and without HFE mutations. Our data suggest that H63D mutation is so frequent in Azerian major beta-thalassemia patients than in the general population and that the coinheritance of H63D mutation does not influence the severity of iron overload in these patients.

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Acknowledgments

This study has not been supported by any foundation.

Conflict of interest

The authors declare that they have no competing interests.

Author information

Authors and Affiliations

  1. Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Abolhassan Ghaderi & Ali Akbar Movasaghpour Akbari

  2. Department of Pathology, Ilam University of Medical sciences, Ilam, Iran

    Mohammad Reza Hafezi Ahmadi

  3. Department of Physiology, Faculty of Para-Veterinary Medicine, Ilam University, Ilam, Iran

    Ehsan Hosseini

  4. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Abbas Ali Hosein Pour Feyzi & Majid Farshdousti Hagh

  5. Children Hospital Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Ataollah Hiradfar

Authors
  1. Abolhassan Ghaderi
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  2. Mohammad Reza Hafezi Ahmadi
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  3. Ehsan Hosseini
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  4. Ali Akbar Movasaghpour Akbari
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  5. Abbas Ali Hosein Pour Feyzi
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  6. Ataollah Hiradfar
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  7. Majid Farshdousti Hagh
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Corresponding author

Correspondence to Majid Farshdousti Hagh.

Additional information

This article has been retracted at the request of the Editor-in-Chief per the Committee on Publication Ethics guidelines. The article shows evidence of irregularities in authorship during the submission process, there is strong reason to believe that the peer review process was compromised and the article contains patchwork plagiarism from a variety of sources.

The main sources are: Hong Kong Med J 2000;6:153-8 | Number 2, June 2000 The C282Y mutation of the HFE gene is not found in Chinese haemochromatotic patients: multicentre retrospective study WMS Tsui, PWY Lam, KC Lee, KF Ma, YK Chan, MWY Wong, SP Yip, CSC Wong, ASF Chow, STH Lo

European Journal of Immunogenetics Volume 27, Issue 3, pages 129–134, June 2000 Iron-overload and genotypic expression of HFE mutations H63D/C282Y and transferrin receptor Hin6I and BanI polymorphism in German patients with hereditary haemochromatosis R. Gottschalk, C. Seidl, S. Schilling, A. Braner, E. Seifried, D. Hoelzer andJ. P. Kaltwasser DOI: 10.1046/j.1365-2370.2000.00215.x

European Journal of Haematology Vol 74 Issue 4 Prevalence of the H63D mutation of the HFE in north India: its presence does not cause iron overload in beta thalassemia trait Gurjeewan Garewal, Reena Das, Jasmina Ahluwalia and R. K. Marwaha DOI: 10.1111/j.1600-0609.2004.00390.x

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As such the validity of the content of this article cannot be verified.

An erratum to this article is available at http://dx.doi.org/10.1007/s00580-016-2359-1.

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Ghaderi, A., Ahmadi, M.R.H., Hosseini, E. et al. RETRACTED ARTICLE: Prevalence of the C282Y and H63D mutations of the HFE hemochromatosis gene in Azerian major β-thalassemia and iron overload. Comp Clin Pathol 25, 151–154 (2016). https://doi.org/10.1007/s00580-015-2156-2

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  • DOI: https://doi.org/10.1007/s00580-015-2156-2

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