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A very severe case of feline amyloidosis with spontaneous hepatic rupture and chronic renal failure

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Abstract

A 3.5-year-old neutered male domestic shorthaired cat presenting with inappetence, depression, polydisia, and severe icteric mucous membranes was diagnosed as having systemic amyloidosis with spontaneous hemorrhage from the liver and chronic renal failure. Laboratory findings were remarkable for anemia, thrombocytopenia, mature neutrophilia, hyperbilirubinemia, azotemia, and hyperphosphatemia. Little treatment was possible and the cat was euthanased later. At necropsy, the entire abdominal cavity was filled with intra-abdominal hemorrhage. Histopathological examination revealed extensive deposition of eosinophilic homogenous material in the parenchyma of the liver and sinusoids. Hepatic amyloid was detected primarily in periacinar regions associated with atrophy of adjacent hepatocytes. In the kidney, marked eosinophilic homogenous material was found in numerous glomeruli and outer medullary area. Amyloid deposits were demonstrated by the Congo red stain. Whether underlying diseases present as risk factors for the severity of clinical and biochemical picture of generalized amyloidosis in this case is unclear.

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Acknowledgements

The authors wish to thank Mr. M Mohammad-Nejad for the excellent technical assistance.

Funding

This study was funded by the Ferdowsi University of Mashhad.

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Authors and Affiliations

  1. Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

    Javad Khoshnegah

  2. Department of Pathobiology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

    Ahmad Reza Movassaghi

Authors
  1. Javad Khoshnegah
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  2. Ahmad Reza Movassaghi
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Correspondence to Javad Khoshnegah.

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Khoshnegah, J., Movassaghi, A.R. A very severe case of feline amyloidosis with spontaneous hepatic rupture and chronic renal failure. Comp Clin Pathol 19, 519–522 (2010). https://doi.org/10.1007/s00580-010-1043-0

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  • DOI: https://doi.org/10.1007/s00580-010-1043-0

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