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Magnesium in obstetric anesthesia and intensive care

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Abstract

Magnesium, one of the essential elements in the human body, has numerous favorable effects that offer a variety of possibilities for its use in obstetric anesthesia and intensive care. Administered as a single intravenous bolus dose or a bolus followed by continuous infusion during surgery, magnesium attenuates stress response to endotracheal intubation, and reduces intraoperative anesthetic and postoperative analgesic requirements, while at the same time preserving favorable hemodynamics. Applied as part of an intrathecal or epidural anesthetic mixture, magnesium prolongs the duration of anesthesia and diminishes total postoperative analgesic consumption with no adverse maternal or neonatal effects. In obstetric intensive care, magnesium represents a first-choice medication in the treatment and prevention of eclamptic seizures. If used in recommended doses with close monitoring, magnesium is a safe and effective medication.

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References

  1. Dubé L, Granry JC. The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine: a review. Can J Anesth. 2003;50(7):732–46.

    Article  PubMed  Google Scholar 

  2. Swaminathan R. Magnesium metabolism and its disorders. Clin Biochem Rev. 2003;24:47–66.

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Herroeder S, Schonherr ME, De Hert SG, Hollmann, MW. Magnesium-essential for the anesthesiologists. Anesthesiology. 2011;114(4):971–93.

  4. Jahnen-Dechent W, Ketteler M. Magnesium basis. Clin Kidney J. 2012;5(Suppl 1):i3–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Fawcett WJ, Haxby EJ, Male DA. Magnesium: physiology and pharmacology. Br J Anaesth. 1999;83:302–20.

    Article  CAS  PubMed  Google Scholar 

  6. Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 2015;7:8199–226.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Touyz RM. Magnesium in clinical medicine. Front Biosci. 2004;9:1278–93.

    Article  CAS  PubMed  Google Scholar 

  8. James MF. Magnesium: an emerging drug in anaesthesia. Br J Anaesth. 2009;103:465–7.

    Article  CAS  PubMed  Google Scholar 

  9. Geiger H, Wanner C. Magnesium in disease. Clin Kidney J. 2012;5(Suppl 1):i25–38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Euser AG, Cipolla MJ. Magnesium sulfate for the treatment of eclampsia: a brief review. Stroke. 2009;40:1169–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Dean C, Douglas J. Magnesium and the obstetric anaesthetist. Int J Obstet Anesth. 2013;22:52–63.

    Article  CAS  PubMed  Google Scholar 

  12. Mesbah Kiaee M, Safari S, Movaseghi GR, Mohaghegh Dolatabadi MR, Ghorbanlo M, Etemadi M, Amiri SA, Zamani MM. The effect of intravenous magnesium sulfate and lidocaine in hemodynamic response to endotracheal intubation in elective coronary artery bypass grafting: a randomized controlled clinical trial. Anesth Pain Med. 2014;4:e15905.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Jee D, Lee D, Yun S, Lee C. Magnesium sulphate attenuates arterial pressure increase during laparoscopic cholecystectomy. Br J Anaesth. 2009;103:484–9.

    Article  CAS  PubMed  Google Scholar 

  14. Elgebaly AS, Eldabaa AA, Abd ELhafez AA, Abdalla MM. Comparison of the analgesic effects of intravenous magnesium sulfate infusion versus intrathecal fentanyl in patients with severe pre-eclampsia undergoing caesarean section. J Obstet Anesth Crit Care. 2011;1:21–5.

    Google Scholar 

  15. Huang CJ, Fan YC, Tsai PS. Differential impacts of modes of anaesthesia on the risk of stroke among preeclamptic women who undergo Caesarean delivery: a population-based study. Br J Anaesth. 2010;105:818–26.

    Article  PubMed  Google Scholar 

  16. Korish AA. Magnesium sulfate therapy of preeclampsia: an old tool with new mechanism of action and prospect in management and prophylaxis. Hypertens Res. 2012;35:1005–11.

    Article  CAS  PubMed  Google Scholar 

  17. Cunha AR, Umbelino B, Correia ML, Neves MF. Magnesium and vascular changes in hypertension. Int J Hypertens. 2012;2012:754250.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Woolf CJ. Central sensitisation. Anesthesiology. 2007;106:864–7.

    Article  PubMed  Google Scholar 

  19. Albrecht E, Kirkham KR, Liu SS, Brull R. Peri-operative intravenous administration of magnesium sulfate and postoperative pain: a meta-analysis. Anaesthesia. 2013;68:79–90.

    Article  CAS  PubMed  Google Scholar 

  20. McGlennan A, Mustafa A. General anaesthesia for Caesarean section. Contin Edu Anaesth Crit Care Pain. 2009;9:148–51.

    Article  Google Scholar 

  21. Brown JPR. Recent developments in anaesthesia for Caesarean section in the UK. Update Anaesth. 2008;23:3–7.

    Google Scholar 

  22. Rollins M, Lucero J. Overview of anesthetic considerations for Caesarean delivery. Br Med Bull. 2012;101:105–25.

    Article  CAS  PubMed  Google Scholar 

  23. Ros HS, Lichtenstein P, Bellocco R, Petersson G, Cnattingius S. Pulmonary embolism and stroke in relation to pregnancy: how can high-risk women be identified? Am J Obstet Gynecol. 2002;186:198–203.

    Article  PubMed  Google Scholar 

  24. Park SJ, Shim YH, Yoo JH, Nam SH, Lee JW. Low-dose remifentanil to modify hemodynamic response to tracheal intubation: comparison in normotensive and untreated/treated hypertensive Korean patients. Korean J Anesthesiol. 2012;62:135–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Fuentes JVR, Flores CEP, Ramirez MV. Anaesthetic management in emergency caesarean section: systematic literature review of anaesthetic techniques for emergency C-section. Rev Colomb Anesthesiol. 2012;40:273–86.

    Google Scholar 

  26. Khan FA, Ullah H. Pharmacological agents for preventing morbidity associated with haemodynamic response to tracheal intubation. Cochrane Database Syst Rev. 2013;7:CD004087.

  27. Cipolla MJ, Sweet JG, Chan SL. Cerebral vascular adaptation to pregnancy and its role in neurological complications of eclampsia. J Appl Physiol. 2011;110:329–39.

    Article  PubMed  Google Scholar 

  28. Hassani V, Movassaghi G, Goodarzi V, Safari S. Comparison of fentanyl and fentanyl plus lidocaine on attenuation of hemodynamic responses to tracheal intubation in controlled hypertensive patients undergoing general anesthesia. Anesth Pain Med. 2013;2:115–8.

    Article  PubMed Central  Google Scholar 

  29. Allen RW, James MF, Uys PC. Attenuation of the pressor response to tracheal intubation in hypertensive proteinuric pregnant patients by lignocaine, alfentanil and magnesium sulphate. Br J Anaesth. 1991;66:216–23.

    Article  CAS  PubMed  Google Scholar 

  30. Bajwa SJ, Kaur J, Singh A, Parmar S, Singh G, Kulshrestha A, Gupta S, Sharma V, Panda A. Attenuation of pressor response and dose sparing of opioids and anaesthetics with pre-operative dexmedetomidine. Indian J Anaesth. 2012;56:123–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Panda NP, Bharti N, Prasad S. Minimal effective dose of magnesium sulfate for attenuation of intubation response in hypertensive patients. J Clin Anesth. 2013;25:92–7.

    Article  CAS  PubMed  Google Scholar 

  32. James MF. The use of magnesium sulfate in pheochromocytoma. Anesthesiology. 1985;62:188–90.

    Article  CAS  PubMed  Google Scholar 

  33. James MF, Beer RE, Esser JD. Intravenous magnesium sulfate inhibits catecholamine release associated with tracheal intubation. Anesth Analg. 1989;68:772–6.

    Article  CAS  PubMed  Google Scholar 

  34. Do SH. Magnesium: a versatile drug for anesthesiologists. Korean J Anesthesiol. 2013;65:4–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Nooraei N, Dehkordi ME, Radpay B, Teimoorian H, Mohajerani SA. Effects of inteavenous magnesium sulfate and lidocaine on hemodynamic variables following direct laryngoscopy and intubation in elective surgery patients. Tanaffos. 2013;12:57–63.

    PubMed  PubMed Central  Google Scholar 

  36. Ashton WB, James MF, Janicki P, Uys PC. Attenuation of the pressor response to tracheal intubation by magnesium sulphate with and without alfentanil in hypertensive proteinuric patients undergoing caesarean section. Br J Anaesth. 1991;67:741–7.

    Article  CAS  PubMed  Google Scholar 

  37. Telci L, Esen F, Akcora D, Erden T, Erden AT, Akpir K. Evaluation of effects of magnesium sulphate in reducing intraoperative anaesthetic requirements. Br J Anaesth. 2002;89:594–8.

    Article  CAS  PubMed  Google Scholar 

  38. Ryu JH, Kang MH, Park KS, Do SH. Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia. Br J Anaesth. 2008;100:397–403.

    Article  CAS  PubMed  Google Scholar 

  39. Ryu JH, Sohn IS, Do SH. Controlled hypotension for middle ear surgery: a comparison between remifentanil and magnesium sulphate. Br J Anaesth. 2009;103:490–5.

    Article  CAS  PubMed  Google Scholar 

  40. Elsharnouby NM, Elsharnouby MM. Magnesium sulphate as a technique of hypotensive anaesthesia. Br J Anaesth. 2006;96:727–31.

    Article  CAS  PubMed  Google Scholar 

  41. Lee DH, Kwon IC. Magnesium sulphate has beneficial effects as an adjuvant during general anaesthesia for Caesarean section. Br J Anaesth. 2009;103:861–6.

    Article  CAS  PubMed  Google Scholar 

  42. Héman L, Linden P. Does magnesium sulfate increase the incidence of postpartum hemorrhage? A systematic review. Open J Obstet Gynecol. 2011;1:168–73.

    Article  Google Scholar 

  43. Song YK, Lee C, Seo DH, Park SN, Moon SY, Park CH. Interaction between postoperative shivering and hyperalgesia caused by high-dose remifentanil. Korean J Anesthesiol. 2014;66:44–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Ghaffaripour S, Mahmoudi H, Eghbal H, Rahimi A. The effect of intravenous magnesium sulfate on post-operative analgesia during laminectomy. Cureus. 2016;8:e626.

    PubMed  PubMed Central  Google Scholar 

  45. Paech MJ, Magann EF, Doherty DA, Verity LJ, Newnham JP. Does magnesium sulfate reduce the short- and long-term requirements for pain relief after caesarean delivery? A double-blind placebo-controlled trial. Am J Obstet Gynecol. 2006;194:1596–602 (discussion 1602-3).

  46. Ko SH, Lim HR, Kim DC, Han YJ, Choe H, Song HS. Magnesium sulfate does not reduce postoperative analgesic requirements. Anesthesiology. 2001;95:640–6.

    Article  CAS  PubMed  Google Scholar 

  47. Lysakowski C, Dumont L, Czarnetzki C, Tramèr MR. Magnesium as an adjuvant to postoperative analgesia: a systematic review of randomized trials. Anesth Analg. 2007;104:1532–9.

    Article  CAS  PubMed  Google Scholar 

  48. Tramer MR, Schneider J, Marti RA, Rifat K. Role of magnesium sulfate in postoperative analgesia. Anesthesiology. 1996;84:340–7.

    Article  CAS  PubMed  Google Scholar 

  49. Kara H, Sahin N, Ulusan V, Aydogdu T. Magnesium infusion reduces perioperative pain. Eur J Anaesthesiol. 2002;19:52–6.

    Article  CAS  PubMed  Google Scholar 

  50. Taheri A, Haryalchi K, Mansour Ghanaie M, Habibi Arejan N. Effect of low-dose (single-dose) magnesium sulfate on postoperative analgesia in hysterectomy patients receiving balanced general anesthesia. Anesthesiol Res Pract. 2015;2015:306145.

    PubMed  PubMed Central  Google Scholar 

  51. Rezae M, Naghibi K, Taefnia AM. Effect of pre-emptive magnesium sulfate infusion on the post-operative pain relief after elective cesarean section. Adv Biomed Res. 2014;3:164.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Mireskandari SM, Pestei K, Hajipour A, Jafarzadeh A, Samadi S, Nabavian O. Effects of preoperative magnesium sulphate on post-cesarean pain, a placebo controlled double blind study. J Family Reprod Health. 2015;9:29–33.

    PubMed  PubMed Central  Google Scholar 

  53. De Oliveira GS, Jr Castro-Alves LJ, Khan JH, McCarthy RJ. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology. 2013;119:178–90.

    Article  PubMed  Google Scholar 

  54. Seyhan TÖ, Bezen O, Sungur MO, Kalelioğlu I, Karadeniz M, Koltka K. Magnesium therapy in pre-eclampsia prolongs analgesia following spinal anaesthesia with fentanyl and bupivacaine: an observational study. Balkan Med J. 2014;31:143–8.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Albrecht E, Kirkham KR, Liu SS, Brull R. The analgesic efficacy and safety of neuraxial magnesium sulphate: a quantitative review. Anesthesia. 2013;68:190–202.

    Article  CAS  Google Scholar 

  56. Morrison AP, Hunter JM, Halpern SH, Banerjee A. Effect of intrathecal magnesium in the presence or absence of local anaesthetic with and without lipophilic opioids: a systematic review and meta-analysis. Br J Anaesth. 2013;110:702–12.

    Article  CAS  PubMed  Google Scholar 

  57. Pascual-Ramírez J, Gil-Trujillo S, Alcantarilla C. Intrathecal magnesium as analgesic adjuvant for spinal anesthesia: a meta-analysis of randomized trials. Minerva Anestesiol. 2013;79:667–78.

    PubMed  Google Scholar 

  58. Ghrab BE, Maatoug M, Kallel N, Khemakhem K, Chaari M, Kolsi K, Karoui A. Does combination of intrathecal magnesium sulfate and morphine improve postcaesarean section analgesia? (in French with English abstract). Ann Fr Anesth Reanim. 2009;28:454–9.

    Article  CAS  PubMed  Google Scholar 

  59. Malleeswaran S, Panda N, Mathew P, Bagga R. A randomized study of magnesium sulfate as an adjuvant to intrathecal bupivacaine in patients with mild preeclampsia undergoing caesarean section. Int J Obstet Anesth. 2010;19:161–6.

    Article  CAS  PubMed  Google Scholar 

  60. Banihhashem N, Hasannasab B, Esmaelli A, Hasannasab B. Addition of intrathecal magnesium sulfate to bupivacaine for spinal anestesia in cesarean section. Anesth Pain Med. 2015;22(3):e22798.

  61. Jabalameli M, Pakzadmoghadam SH. Adding different doses of intrathecal magnesium sulfate for spinal anesthesia in the cesarean section: a prospective double blind randomized trial. Adv Biomed Res. 2012;1:7.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Sayed JA, Fathy MA. Maternal and neonatal effects of adding two different doses of intrathecal magnesium sulphate to bupivacaine fentanyl spinal anesthesia in mild preeclamptic patients undergoing caesarean section. J Am Sci. 2012;8:435–41.

    Google Scholar 

  63. Hasanein R, El-sayed W, Khalil M. The value of epidural magnesium sulfate as an adjuvant to bupivacaine and fentanyl for labor analgesia. Egyptian J Anaesth. 2013;29:219–24.

    Article  Google Scholar 

  64. Mebazaa MS, Ouerghi S, Frikha N, Moncer K, Mestiri T, James MF, Ben Ammar MS. Is magnesium sulfate by the intrathecal route efficient and safe? Ann Fr Anesth Reanim. 2011;30:47–50.

    Article  CAS  PubMed  Google Scholar 

  65. Bilir A, Gulec S, Erkan A, Ozcelik A. Epidural magnesium reduces postoperative analgesic requirement. Br J Anaesth. 2007;98:519–23.

    Article  CAS  PubMed  Google Scholar 

  66. Sun J, Wu X, Xu X, Jin L, Han N, Zhou R. A comparison of epidural magnesium and/or morphine with bupivacaine for postoperative analgesia after cesarean section. Int J Obstet Anesth. 2012;21:310–6.

    Article  PubMed  Google Scholar 

  67. Banwait S, Sharma S, Pawar M, Garg R, Sood R. Evaluation of single epidural bolus dose of magnesium as an adjuvant to epidural fentanyl for postoperative analgesia: a prospective, randomized, double-blind study. Saudi J Anaesth. 2012;6:273–8.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Yousef AA, Amr YM. The effect of adding magnesium sulphate to epidural bupivacaine and fentanyl in elective caesarean section using combined spinal-epidural anaesthesia: a prospective double blind randomised study. Int J Obstet Anesth. 2010;19:401–4.

    Article  CAS  PubMed  Google Scholar 

  69. Sadeh M. Action of magnesium sulfate in the treatment of preeclampsia-eclampsia. Stroke. 1989;20:1273–5.

    Article  CAS  PubMed  Google Scholar 

  70. Duley L. Pre-eclampsia and hypertensive disorders of pregnancy. Br Med Bull. 2003;67:161–76.

    Article  PubMed  Google Scholar 

  71. Dennis AT. Management of pre-eclampsia: issues for anaesthetists. Anaesthesia. 2012;67:1009–20.

    Article  CAS  PubMed  Google Scholar 

  72. Duley L. Gülmezoglu AM, Henderson-Smart DJ, Chou D. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev. 2010;(11):CD000025.

  73. Staykov D, Schwab S. Posterior reversible encephalopathy syndrome. J Intensive Care Med. 2012;27:11–24.

    Article  PubMed  Google Scholar 

  74. O’Sullivan G. Considerations when devising a protocol for pre-eclampsia. Acta Medica Lituanica. 2012;19:115–22.

    Google Scholar 

  75. Witlin AG, Friedman SA, Sibai BM. The effect of magnesium sulfate therapy on the duration of labor in women with mild preeclampsia at term: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 1997;176:623–7.

    Article  CAS  PubMed  Google Scholar 

  76. Atkinson MW, Guinn D, Owen J, Hauth JC. Does magnesium sulfate affect the length of labor induction in women with pregnancy-associated hypertension? Am J Obstet Gynecol. 1995;173:1219–22.

    Article  CAS  PubMed  Google Scholar 

  77. Leveno KJ, Alexander JM, McIntire DD, Lucas MJ. Does magnesium sulfate given for prevention of eclampsia affect the outcome of labor? Am J Obstet Gynecol. 1998;178:707–12.

    Article  CAS  PubMed  Google Scholar 

  78. Johnson AC, Tremble SM, Chan SL, Moseley J, LaMarca B, Nagle KJ, Cipolla MJ. Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. PLoS One. 2014;9:e113670.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Marchi N, Tierney W, Alexopoulos AV, Puvenna V, Granata T, Janigro D. The etiological role of blood-brain barrier dysfunction in seizure disorders. Cardiovasc Psychiatry Neurol. 2011;2011:482415.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Oliveira LD, Oliveira RW, Futuro Neto Hde A, Nakamura-Palacios EM. The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats. Arq Neuropsiquiatr. 2011;69:349–55.

    Article  PubMed  Google Scholar 

  81. Chang JJ, Mack WJ, Saver JL, Sanossian N. Magnesium: potential roles in neurovascular disease. Front Neurol. 2014;5:52.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Cipolla MJ, Kraig RP. Seizures in women with preeclampsia: mechanisms and management. Fetal Matern Med Rev. 2011;22:91–108.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Cipolla MJ. Cerebrovascular function in pregnancy and eclampsia. Hypertension. 2007;50:14–24.

    Article  CAS  PubMed  Google Scholar 

  84. Gao F, Ding B, Zhou L, Gao X, Guo H, Xu H. Magnesium sulfate provides neuroprotection in lipopolysaccharide-activated primary microglia by inhibiting NF-κB pathway. J Surg Res. 2013;184:944–50.

    Article  PubMed  Google Scholar 

  85. Thurnau GR, Kemp DB, Jarvis A. Cerebrospinal fluid levels of magnesium in patients with preeclampsia after treatment with intravenous magnesium sulfate: a preliminary report. Am J Obstet Gynecol. 1987;157:1435–8.

    Article  CAS  PubMed  Google Scholar 

  86. McKee JA, Brewer RP, Macy GE, Phillips-Bute B, Campbell KA, Borel CO, Reynolds JD, Warner DS. Analysis of the brain bioavailability of peripherally administered magnesium sulfate: a study in humans with acute brain injury undergoing prolonged induced hypermagnesemia. Crit Care Med. 2005;33:661–6.

    Article  CAS  PubMed  Google Scholar 

  87. Oppelt WW, Mac Intyre J, Rall DP. Magnesium exchange between blood and cerebrospinal fluid. Am J Physiol. 1963;205:959–62.

    CAS  PubMed  Google Scholar 

  88. Brewer RP, Parra A, Borel CO, Hopkins MB, Reynolds JD. Intravenous magnesium sulfate does not increase ventricular CSF ionized magnesium concentration of patients with intracranial hypertension. Clin Neuropharmacol. 2001;24:341–5.

    Article  CAS  PubMed  Google Scholar 

  89. Apostol A, Apostol R, Ali E, Choi A, Ehsuni N, Hu B, Li L, Altura BT, Altura BM. Cerebral spinal fluid and serum ionized magnesium and calcium levels in preeclamptic women during administration of magnesium sulfate. Fertil Steril. 2010;94(1):276–82.

    Article  CAS  PubMed  Google Scholar 

  90. Muir KW. Magnesium in stroke treatment. Postgrad Med J. 2002;78:641–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Okusanya BO, Oladapo OT, Long Q, Lumbiganon P, Carroli G, Qureshi Z, Duley L, Souza JP, Gülmezoglu AM. Clinical pharmacokinetic properties of magnesium sulphate in women with pre-eclampsia and eclampsia. BJOG. 2016;123:356–66.

    Article  CAS  PubMed  Google Scholar 

  92. Royal College of Obstetricians and Gynaecologists. The management of severe preeclampsia and eclampsia. Guideline No 10(A). 2010;1–11.

  93. Bain ES, Middleton PF, Crowther CA. Maternal adverse effects of different antenatal magnesium sulphate regimens for improving maternal and infant outcomes: a systematic review. BMC Pregnancy Childbirth. 2013;13:195.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Smith JM, Lowe RF, Fullerton J, Currie SM, Harris L, Felker-Kantor E. An integrative review of the side effects related to the use of magnesium sulfate for pre-eclampsia and eclampsia management. BMC Pregnancy Childbirth. 2013;13:34.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Kane SC, Dennis A, da Silva Costa F, Kornman L, Brennecke S. Contemporary clinical management of the cerebral complications of preeclampsia. Obstet Gynecol Int. 2013;2013:985606.

    PubMed  PubMed Central  Google Scholar 

  96. Walker JJ. Pre-eclampsia. Lancet. 2000;356:1260–5.

    Article  CAS  PubMed  Google Scholar 

  97. Balofsky A, Fedarau M. Renal failure in pregnancy. Crit Care Clin. 2016;32(1):73–83.

    Article  PubMed  Google Scholar 

  98. Roberts JM. Pregnancy related hypertension. In: Creasy RK, Resnik R, editors. Maternal—fetal medicine. Philadelphia: WB Saunders; 1999. p. 833–72.

    Google Scholar 

  99. Tukur J. The use of magnesium sulphate for the treatment of severe pre-eclampsia and eclampsia. Ann Afr Med. 2009;8:76–80.

    Article  PubMed  Google Scholar 

  100. Lu JF, Nightingale CH. Magnesium sulfate in eclampsia and pre-eclampsia: pharmacokinetic principles. Clin Pharmacokinet. 2000;38:305–14.

    Article  CAS  PubMed  Google Scholar 

  101. Gambling DR. Magnesium and the obstetric anesthetist. Int J Obstet Anesth. 2013;22:255.

    Article  CAS  PubMed  Google Scholar 

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Kutlesic, M.S., Kutlesic, R.M. & Mostic-Ilic, T. Magnesium in obstetric anesthesia and intensive care. J Anesth 31, 127–139 (2017). https://doi.org/10.1007/s00540-016-2257-3

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