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Liver functional volumetry for portal vein embolization using a newly developed 99mTc-galactosyl human serum albumin scintigraphy SPECT–computed tomography fusion system

  • Original Article—Liver, Pancreas, and Biliary Tract
  • Published:
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Abstract

Background

We developed a new combined 99mTc-galactosyl human serum albumin (GSA) scintigraphy single-photon emission computed tomography (SPECT)/CT system to evaluate the changes in functional liver volume with portal vein embolization (PVE).

Methods

We performed a prospective analysis of 25 patients treated with right PVE, and evaluated their functional liver volume perioperatively with a 99mTc-GSA scintigraphy SPECT–CT fusion system. The percentage of the non-tumorous remnant liver volume (%LV) and the percentage of functional remnant liver volume (%FLV) were estimated by using the following calculations: (future remnant volume − tumor volume)/(total liver volume − tumor volume) and functional future remnant liver volume/functional total liver volume, respectively.

Results

Before PVE, the correlation was strongly significant between %LV and %FLV of the non-embolized liver, and the data were nearly equal (the regression coefficient was 1.005, P < 0.0001). In contrast, after PVE, there was a significant correlation between %LV and %FLV (P < 0.0001), but the regression coefficient was 1.192. The % LV increased significantly, from 38.1 to 52.0%, and the increment was 13.9% (P < 0.0005). The %FLV was also increased significantly, from 36.6 to 58.0%, and the increment was 21.4% (P < 0.0001). The increment was 7.5% greater for the %FLV compared to that of the %LV (P < 0.001).

Conclusions

The 99mTc-GSA scintigraphy SPECT–CT fusion system can estimate the correct functional liver volume and is useful in comparison with conventional CT volumetry.

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Abbreviations

HCC:

Hepatocellular carcinoma

PVE:

Portal vein embolization

%LV:

Percentage of non-tumorous remnant liver volume

%FLV:

Percentage of functional remnant liver volume

SPECT:

Single-photon emission computed tomography

99mTc-GSA scintigraphy:

99mTc-galactosyl human serum albumin scintigraphy

LHL 15:

Uptake ratio of the liver to the liver plus heart at 15 min

ICG R15:

Indocyanine green retention rate at 15 min

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Conflict of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan

    Toru Beppu, Hiromitsu Hayashi, Hirohisa Okabe, Toshiro Masuda, Kosuke Mima, Ryu Otao, Akira Chikamoto, Koichi Doi, Takatoshi Ishiko, Hiroshi Takamori & Hideo Baba

  2. Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan

    Morikatsu Yoshida, Shinya Shiraishi & Yasuyuki Yamashita

Authors
  1. Toru Beppu
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  2. Hiromitsu Hayashi
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  3. Hirohisa Okabe
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  4. Toshiro Masuda
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  5. Kosuke Mima
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  6. Ryu Otao
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  7. Akira Chikamoto
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  8. Koichi Doi
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  9. Takatoshi Ishiko
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  10. Hiroshi Takamori
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  11. Morikatsu Yoshida
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  12. Shinya Shiraishi
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  13. Yasuyuki Yamashita
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  14. Hideo Baba
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Corresponding author

Correspondence to Hideo Baba.

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Beppu, T., Hayashi, H., Okabe, H. et al. Liver functional volumetry for portal vein embolization using a newly developed 99mTc-galactosyl human serum albumin scintigraphy SPECT–computed tomography fusion system. J Gastroenterol 46, 938–943 (2011). https://doi.org/10.1007/s00535-011-0406-x

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  • DOI: https://doi.org/10.1007/s00535-011-0406-x

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