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Prevalence of sleep disturbances in children and adolescents with chronic kidney disease

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Abstract

Although sleep disorders are common in adults with chronic kidney disease, little is known about the prevalence of sleep problems in children and adolescents with chronic kidney disease and their relationship to health-related quality of life measurements. We performed a clinic-based survey of sleep habits and common symptoms of sleep disturbances in 159 school-aged patients with chronic kidney disease. Three patient groups of chronic kidney disease were assessed: group 1, those not on dialysis and not transplanted; group 2, those on dialysis; and group 3, those with a functioning renal allograft. Four symptom domains for sleep disorders were assessed: excessive daytime sleepiness; sleep disordered breathing; restless legs syndrome symptoms; and insufficient sleep. Patients and the parent-proxy also completed the Pediatric Quality of Life Inventory Version 4.0 Generic Core Scales questionnaire. Ninety-three (93) patients (58.5%) had symptoms of a sleep disturbance. The presence of a sleep disturbance correlated with a decrease in health-related quality of life scores that was independent of the chronic kidney disease study group or estimated glomerular filtration rate. We conclude that sleep disturbances are common throughout the spectrum of chronic kidney disease in children and adolescents and are associated with diminished health-related quality of life scores.

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Acknowledgements

We thank the patients who agreed to participate in this study and the study coordinators who played an integral part in the patient recruitment process and collection of study data. The authors also acknowledge Charlene Stubbs, Leslie Herzog, and Radha Pullalarevu with the preparation of this manuscript.

Support

This study was funded by the Leonard C. Rosenberg Foundation, a support organization of the Centers for Dialysis Care, Cleveland, Ohio.

Financial disclosure

IDD and LLW are full-time employees of Baxter Healthcare Corporation.

Author information

Author notes

  1. Debbie Gipson

    Present address: Division of Nephrology, CS Mott Children’s Hospital, F6865, University of Michigan Medical School, Ann Arbor, MI, USA

Authors and Affiliations

  1. Department of Pediatrics, Rainbow Babies and Children’s Hospital/Case Western Reserve University, Cleveland, OH, USA

    Ira D. Davis, Judith L. Emancipator & Carol L. Rosen

  2. Baxter Healthcare Corporation, 1620 Waukegan Road, McGaw Park, IL 60085, USA

    Ira D. Davis & Lie Ling Wu

  3. Department of Pediatrics, Emory University and Children’s Healthcare of Atlanta, Atlanta, GA, USA

    Larry A Greenbaum

  4. Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Debbie Gipson

  5. Department of Pediatrics, British Columbia Children’s Hospital, Vancouver, British Columbia, Canada

    Rajiv Sinha & Mina Matsuda-Abedini

  6. Division of Kidney Diseases, Department of Pediatrics, Children’s Memorial Hospital, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

    Jerome C. Lane & Kavita Hodgkins

  7. Department of Pediatrics, James Whitcomb Riley Hospital for Children/Indiana University, Indianapolis, IN, USA

    Corina Nailescu

  8. Department of Pediatrics, DeVos Children’s Hospital, Grand Rapids, MI, USA

    Gina Marie Barletta

  9. Department of Pediatrics, McMaster Children’s Hospital, Hamilton, Ontario, Canada

    Steven Arora

  10. Department of Pediatrics, Nationwide Children’s Hospital/The Ohio State University, Columbus, OH, USA

    John D. Mahan

Authors
  1. Ira D. Davis
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  2. Larry A Greenbaum
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Correspondence to Ira D. Davis.

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Davis, I.D., Greenbaum, L.A., Gipson, D. et al. Prevalence of sleep disturbances in children and adolescents with chronic kidney disease. Pediatr Nephrol 27, 451–459 (2012). https://doi.org/10.1007/s00467-011-2010-y

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