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Endoscopic ultrasound-guided fine needle aspiration improves the pre-operative diagnostic yield of solid-pseudopapillary neoplasm of the pancreas: an international multicenter case series (with video)

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An Erratum to this article was published on 10 July 2014

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Background/Objectives

Solid-pseudopapillary neoplasms (SPNs) are rare pancreatic tumors, which occur most frequently in young women and are associated with an excellent prognosis. Computed tomography (CT) is used most commonly to identify these lesions, but there are few studies evaluating the role of endoscopic ultrasound (EUS) and fine needle aspiration (EUS-FNA) in the assessment of SPN. The aim of the study was to determine the incremental diagnostic yield of EUS-FNA compared with CT or EUS in the evaluation of patients with SPN.

Methods

A retrospective chart review of consecutive patients diagnosed with SPN who underwent CT, EUS, and EUS-FNA at five centers from three countries from 1998 to 2013. Patient demographics, imaging, endoscopic studies, cytopathology, and histology were reviewed.

Results

Thirty-four patients were identified with SPN. There were 31 (91.2 %) females, with a mean age at diagnosis of 37 years (range 16-81). The most common presenting symptom was abdominal pain which was present in 59 %. SPNs were incidentally detected in 14 (41.2 %) of the patients. The median tumor size was 4.2 cm (range 1.9–9.4). No patient had evidence of local or distant metastases. The most common appearance on EUS was of a mixed solid-cystic lesion (67.6 %). The diagnostic yield of CT and EUS alone was 23.5 and 41.2 %, respectively. CT and EUS combined had a diagnostic yield of 52.9 %. The addition of EUS-FNA significantly increased the diagnostic yield to 82.4 % compared with either CT or CT and EUS (p < 0.005). There were no reported adverse events reported.

Conclusions

SPNs are rare pancreatic tumors primarily affecting young women. The addition of EUS-FNA significantly increased the pre-operative diagnostic yield of SPN to 82.4 %.

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Abbreviations

CT:

Computed tomography

EUS:

Endoscopic ultrasound

EUS-FNA:

Endoscopic ultrasound-guided fine needle aspiration

SPN:

Solid-pseudopapillary neoplasms

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Acknowledgments

We would like to thank Dr. Ralph Hruban for reviewing the manuscript. We would like to acknowledge Dr. Siva Raman from the Department of Radiology, and Dr. Matthew Olson from the Department of Pathology at Johns Hopkins Hospital, for the radiology and cytopathology images respectively. This work was supported by the National Cancer Institute Grant P30CA006973. Dr. Joanna Law is the Volker Dolch Fellow in Gastroenterology at Johns Hopkins Hospital.

Disclosures

Mouen A. Khashab is a consultant for Boston Scientific and Olympus America and has received research support from Cook Medical. Vikesh K. Singh is a consultant for Abbvie, Santarus, D-Pharm, and Boston Scientific. Anne Marie Lennon is a consultant for Boston Scientific. Joanna K. Law, Alina Stoita, Wallia Weaver, Ferga C. Gleeson, Andrew M. Dries, Amanda Blackford, Vandhana Kiswani, Eun Ji Shin, Marcia I. Canto have nothing to disclose.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, 1800 Orleans St, Suite 7125 J, Baltimore, MD, 21205, USA

    Joanna K. Law, Vandhana Kiswani, Eun Ji Shin, Mouen A. Khashab, Marcia Irene Canto, Vikesh K. Singh & Anne Marie Lennon

  2. Department of Gastroenterology, St. Vincent’s Hospital, Sydney, NSW, Australia

    Alina Stoita

  3. Unidad de Exploraciones Digestivas, IMLF, Caracas, Venezuela

    Wallia Weaver

  4. Division of Gastroenterology, Mayo Clinic College of Medicine, Rochester, MN, USA

    Ferga C. Gleeson

  5. Division of Gastroenterology, Carolinas Medical Center, Charlotte, NC, USA

    Andrew M. Dries

  6. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Amanda Blackford

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  1. Joanna K. Law
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  9. Mouen A. Khashab
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Correspondence to Joanna K. Law.

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Law, J.K., Stoita, A., Weaver, W. et al. Endoscopic ultrasound-guided fine needle aspiration improves the pre-operative diagnostic yield of solid-pseudopapillary neoplasm of the pancreas: an international multicenter case series (with video). Surg Endosc 28, 2592–2598 (2014). https://doi.org/10.1007/s00464-014-3508-8

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