Skip to main content

Advertisement

SpringerLink
Log in

Efficiency of liposomal albendazole for the treatment of the patients with complex alveolar echinococcosis: a comparative analysis of CEUS, CT, and PET/CT

  • Original Paper
  • Published:
Parasitology Research Aims and scope Submit manuscript

Abstract

We aim to investigate the efficiency of liposomal albendazole (L-ABZ) for the treatment of complex alveolar echinococcosis (CAE) using contrast-enhanced ultrasonography (CEUS), computed tomography (CT), and positron emission tomography (PET)/CT. Twelve patients with CAE admitted to our hospital between June 2000 and June 2011 were included in this retrospective study. CEUS, CT, and PET/CT were used to evaluate the clinical efficiency of L-ABZ for these patients. Effectiveness was defined as significant response after chemotherapy. Effectiveness with clinical significance was defined as complete response after chemotherapy, and non-effectiveness was defined as no response after chemotherapy. Patients were followed up for 3–11 years. Ten patients (83.3 %) had a ratio of averaged gray scale in the enhanced band to that of hepatic tissues of ≤1.1, and six patients (50.0 %) had a ratio of ≤0.9 as revealed by CEUS. CT scanning results indicated an effective rate of 91.6 %. PET/CT indicated a maximal standard uptake (SUVmax) of <2.5 in nine patients (75.0 %), which was considered to be effective. A high uptake of fluorodeoxyglucose was observed in three patients (25.0 %) with SUVmax ≥2.5, which was considered to be non-effective. Taken together, CEUS, CT, and PET/CT provide objective evaluation of the clinical efficiency of L-ABZ for the treatment of CAE.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Azizi A, Blagosklonov O, Lounis A, Berthet L, Vuitton DA, Bresson-Hadni S, Delabrousse E (2014) Alveolar echinococcosis: correlation between hepatic MRI findings and FDG-PET/CT metabolic activity. Abdom Imaging doi:10.1007/s00261-014-0183-0

  • Bardonnet K, Vuitton DA, Grenouillet F, Mantion GA, Delabrousse E, Blagosklonov O, Miguet JP, Bresson-Hadni S (2013) 30-year course and favorable outcome of alveolar echinococcosis despite multiple metastatic organ involvement in a non-immune suppressed patient. Ann Clin Microbiol Antimicrob 12:1. doi:10.1186/1476-0711-12-1

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Becce F, Pomoni A, Uldry E, Halkic N, Yan P, Meuli R, Schmidt S (2014) Alveolar echinococcosis of the liver: diffusion-weighted MRI findings and potential role in lesion characterisation. Eur J Radiol 83(4):625–631. doi:10.1016/j.ejrad.2013.12.025

    Article  PubMed  Google Scholar 

  • Brunetti E, Kern P, Vuitton DA (2010) Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 114(1):1–16. doi:10.1016/j.actatropica.2009.11.001

    Article  PubMed  Google Scholar 

  • Crouzet J, Grenouillet F, Delabrousse E, Blagosklonov O, Thevenot T, Di Martino V, Piarroux R, Mantion GA, Bresson-Hadni S (2009) Personalized management of patients with inoperable alveolar echinococcosis undergoing treatment with albendazole: usefulness of positron-emission-tomography combined with serological and computed tomography follow-up. Clin Microbiol Infect 16(6):788–791. doi:10.1111/j.1469-0691.2009.02924.x

    Article  PubMed  Google Scholar 

  • Dinkel A, Kern S, Brinker A, Oehme R, Vaniscotte A, Giraudoux P, Mackenstedt U, Romig T (2011) A real-time multiplex-nested PCR system for coprological diagnosis of Echinococcus multilocularis and host species. Parasitol Res 109(2):493–498. doi:10.1007/s00436-011-2272-0

    Article  PubMed  Google Scholar 

  • Eckert J, Thompson RC, Michael SA, et al. (1989) Echinococcus granulosus of camel origin: development in dogs and parasite morphology. 75(7):536–44

  • Ehrhardt AR, Reuter S, Buck AK, Haenle MM, Mason RA, Gabelmann A, Kern P, Kratzer W (2007) Assessment of disease activity in alveolar echinococcosis: a comparison of contrast enhanced ultrasound, three-phase helical CT and [(18)F] fluorodeoxyglucose positron emission tomography. Abdom Imaging 32(6):730–736. doi:10.1007/s00261-007-9177-5

    Article  PubMed  Google Scholar 

  • Gottstein B, Dai WJ, Walker M et al (2002) An intact laminated layer is important for the establishment of secondary Echinococcus multilocularis infection. Parasitol Res 88(9):822–828

    Article  PubMed  Google Scholar 

  • Kratzer W, Reuter S, Hirschbuehl K, Ehrhardt AR, Mason RA, Haenle MM, Kern P, Gabelmann A (2005) Comparison of contrast-enhanced power Doppler ultrasound (Levovist) and computed tomography in alveolar echinococcosis. Abdom Imaging 30(3):286–290. doi:10.1007/s00261-004-0263-7

    Article  CAS  PubMed  Google Scholar 

  • Li HT, Shan JY, Shao YM, Tuergan A, Ayifuhan A, Ran B, Wen H (2011) Clinical effect and safety of liposomal-albendazole and tablet-albendazole for the treatment of human cystic echinococcosis. Zhonghua Gan Zang Bing Za Zhi 19(7):532–536

    CAS  PubMed  Google Scholar 

  • Li H, Song T, Shao Y, Tuergan A, Ran B, Wen H (2013) Chemotherapy in alveolar echinococcosis of multi-organs: what’s the role? Parasitol Res 112(6):2237–2243. doi:10.1007/s00436-013-3382-7

    Article  PubMed  Google Scholar 

  • McManus DP, Zhang W, Li J, Bartley PB (2003) Echinococcosis. Lancet 362(9392):1295–1304. doi:10.1016/S0140-6736(03)14573-4

    Article  PubMed  Google Scholar 

  • Reuter S, Nüssle K, Kolokythas O, Haug U, Rieber A, Kern P, Kratzer W (2001) Alveolar liver echinococcosis: a comparative study of three imaging techniques. Infection 29(3):119–125

    Article  CAS  PubMed  Google Scholar 

  • Reuter S, Buck A, Manfras B, Kratzer W, Seitz HM, Darge K, Reske SN, Kern P (2004) Structured treatment interruption in patients with alveolar echinococcosis. Hepatology 39(2):509–517. doi:10.1002/hep.20078

    Article  PubMed  Google Scholar 

  • Sahin M, Aydin A, Bulbuloglu E, Ciralik H (1997) Experimental hydatid disease of the liver. Eur J Clin Invest 27(6):537–538

    Article  CAS  PubMed  Google Scholar 

  • Said-Ali Z, Grenouillet F, Knapp J, Bresson-Hadni S, Vuitton DA, Raoul F, Richou C, Millon L, Giraudoux P, Francechino Network (2013) Detecting nested clusters of human alveolar echinococcosis. Parasitology 140(13):1693–1700. doi:10.1017/S0031182013001352

    Article  PubMed  Google Scholar 

  • Song T, Li H, Yang L, Yao L, Wen H (2014) Contrast-enhanced ultrasonography of hepatic alveolar echinococcosis in rats: the correlation of imaging fractures and histologic microvascular density. Chinese J Parasitology and Parasitic Diseases 32(3):200–204

    Google Scholar 

  • Staudt U, Schmahl G, Blaschke G, Mehlhorn H (1992) Light and scanning electron microscopy studies on the effects of the enantiomers of praziquantel and its main metabolite on Schistosoma mansoni in vitro. Parasitol Res 78:392–397

    Article  CAS  PubMed  Google Scholar 

  • Stumpe KD, Renner-Schneiter EC, Kuenzle AK, Grimm F, Kadry Z, Clavien PA, Deplazes P, von Schulthess GK, Muellhaupt B, Ammann RW, Renner EL (2007) F-18-fluorodeoxyglucose (FDG) positron-emission tomography of Echinococcus multilocularis liver lesions: prospective evaluation of its value for diagnosis and follow-up during benzimidazole therapy. Infection 35(1):11–18. doi:10.1007/s15010-007-6133-9

    Article  CAS  PubMed  Google Scholar 

  • Tao S, Qin Z, Hao W, Yongquan L, Lanhui Y, Lei Y (2011) Usefulness of gray-scale contrast-enhanced ultrasonography (SonoVue(R)) in diagnosing hepatic alveolar echinococcosis. Ultrasound Med Biol 37(7):1024–1028. doi:10.1016/j.ultrasmedbio.2011.04.014

    Article  PubMed  Google Scholar 

  • Vuitton DA (2009) Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus? Expert Rev Anti Infect Ther 7(2):145–149. doi:10.1586/14787210.7.2.145

    Article  CAS  PubMed  Google Scholar 

  • Wen H, New RR, Muhmut M, Wang JH, Wang YH, Zhang JH, Shao YM, Craig PS (1996) Pharmacology and efficacy of liposome-entrapped albendazole in experimental secondary alveolar echinococcosis and effect of co-administration with cimetidine. Parasitology 113(Pt 2):111–121

    Article  CAS  PubMed  Google Scholar 

  • Zhang W, Zhang Z, Wu W, Shi B, Li J, Zhou X, Wen H, McManus DP (2014) Epidemiology and control of echinococcosis in central Asia, with particular reference to the People’s Republic of China. Acta Trop. doi: 10.1016/j.actatropica.2014.03.014

Download references

Acknowledgments

This work was supported by the Project China Postdoctoral Science Foundation (No. 2014M552570XB); the National Clinical Key Subject-General Surgery Construction Project; and the National Science Foundation of China (No. 81260220).

Conflict of interests

No conflict of interests was claimed by the authors.

Author information

Authors and Affiliations

  1. Hepatobiliary and Hydatid Department, Digestive and Vascular Surgery Centre, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China

    Haitao Li, Yingmei Shao & Hao Wen

  2. State Key Lab Incubation Base of Xinjiang Major Diseases Research (2010DS890294) and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China

    Haitao Li, Tao Song, Wenya Liu, Yingmei Shao & Hao Wen

  3. Department of Ultrasonography, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China

    Tao Song

  4. Department of Nuclear Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, China

    Yongde Qin & Xiaohong Li

Authors
  1. Haitao Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tao Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yongde Qin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wenya Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiaohong Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yingmei Shao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hao Wen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hao Wen.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, H., Song, T., Qin, Y. et al. Efficiency of liposomal albendazole for the treatment of the patients with complex alveolar echinococcosis: a comparative analysis of CEUS, CT, and PET/CT. Parasitol Res 114, 4175–4180 (2015). https://doi.org/10.1007/s00436-015-4649-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00436-015-4649-y

Keywords

Search

Navigation