Skip to main content

Advertisement

SpringerLink
Log in

Tobacco smoke in infants with bronchopulmonary dysplasia

  • Original Article
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Exposure to tobacco smoke has been not evaluated in children with bronchopulmonary dysplasia (BPD). We evaluate the association of in utero smoking (IUS) and environmental tobacco smoke (ETS) with the respiratory events of BPD and non-BPD children. Two hundred sixty-two children born before 35 weeks of gestational age (GA) and regularly followed up in our regional network for preterms were enrolled. They were paired according to their BPD status, their gestational age and birth weight (131 children with BPD and 131 without BPD, 28 mean weeks GA; mean weight 1000 g). Respiratory data were obtained prospectively during their first 2 years of life. A complementary questionnaire was completed by the parents about their child’s respiratory health at the age of 2, their home environment, and tobacco status. IUS concerned 12.6 %; ETS, 48.8 % (67 % in BPD children treated with oxygen at home). No further influence on respiratory outcome could be found by exposure to intrauterine smoke or extrauterine tobacco smoke in this patient sample.

Conclusion: IUS and ETS exposures are as high in preterm children as in a general pediatric population. The highest exposure occurs among BPD infants treated with oxygen at home.

What is known:

• Environmental tobacco smoke (ETS) and in utero smoking (IUS) are responsible for many morphological, functional, and clinical changes in children.

• Children with bronchopulmonary dysplasia (BPD) have more respiratory events in their first years of life than preterm children without BPB, maybe triggered by ETS and IUS.

What is New:

• The exposition to ETS and IUS is high in preterm children with and without BDP, as high as in a general.

• Pedaitric population, particularly in children with BPD and treated with oxygen at home.

• No further influence on respiratory outcome could be found by exposure to ETS or IUS in our studied population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Abbreviations

BPD:

Bronchopulmonary dysplasia

ETS:

Environmental tobacco smoke

GA:

Gestational age

IUS:

In utero smoking

References

  1. Anderson HR, Cook DG (1997) Passive smoking and sudden infant death syndrome: review of the epidemiological evidence. Thorax 52:1003–1009

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Antonucci R, Contu P, Porcella A, Atzeni C, Chiappe S (2004) Intrauterine smoke exposure: a new risk factor for bronchopulmonary dysplasia? J Perinat Med 32:272–277

    PubMed  Google Scholar 

  3. Baska T, Warren CW, Basková M, Jones NR (2009) Prevalence of youth cigarette smoking and selected social factors in 25 European countries: findings from the Global Youth Tobacco Survey. Int J Public Health 54:439–445

    Article  PubMed  Google Scholar 

  4. Blondel B, Norton J, du Mazaubrun C, Bréart G (2001) Development of the main indicators of perinatal health in metropolitan France between 1995 and 1998. Results of the national perinatal survey. J Gynecol Obstet Biol Reprod (Paris) 30:552–564

    CAS  Google Scholar 

  5. Bowman E, Yu VY (1988) Continuing morbidity in extremely low birthweight infants. Early Hum Dev 18:165–174

    Article  CAS  PubMed  Google Scholar 

  6. Bradley JP, Bacharier LB, Bonfiglio J, Schechtman KB, Strunk R, Storch G G et al (2005) Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy. Pediatrics 115:e7–14

    PubMed  Google Scholar 

  7. Burguet A, Berard M, Woronoff AS, Roth P, Menetrier M, Vanlemmens P et al (2001) An appreciation of maternal smoking with high-performance liquid chromatographic determination of maternal and neonatal urinary cotinine. J Gynecol Obstet Biol Reprod (Paris) 30:166–173

    CAS  Google Scholar 

  8. Burguet A, Kaminski M, Abraham-Lerat L, Schaal J-P, Cambonie G, Fresson J et al (2004) The complex relationship between smoking in pregnancy and very preterm delivery. Results of the Epipage study. BJOG 111:258–265

    Article  PubMed  Google Scholar 

  9. Burguet A, Kaminski M, Truffert P, Menget A, Marpeau L, Voyer M et al (2005) Does smoking in pregnancy modify the impact of antenatal steroids on neonatal respiratory distress syndrome? Results of the Epipage study. Arch Dis Child Fetal Neonatal Ed 90:F41–45

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Callais F, Momas I, Roche D, Gauvin S, Reungoat P, Zmirou D (2003) Questionnaire or objective assessment for studying exposure to tobacco smoke among asthmatic and healthy children: the French VESTA Study. Prev Med 36:108–113

    Article  CAS  PubMed  Google Scholar 

  11. Doyle LW, Ford G, Davis N (2003) Health and hospitalisations after discharge in extremely low birth weight infants. Semin Neonatol 8:137–145

    Article  PubMed  Google Scholar 

  12. Goyal NK, Fiks AG, Lorch SA (2011) Association of late-preterm birth with asthma in young children: practice-based study. Pediatrics 128:e830–838

    Article  PubMed Central  PubMed  Google Scholar 

  13. Guimarães H, Rocha G, Pissarra S, Guedes MB, Nunes T, Vitor B (2011) Respiratory outcomes and atopy in school-age children who were preterm at birth, with and without bronchopulmonary dysplasia. Clinics (Sao Paulo) 66:425–430

    Article  Google Scholar 

  14. Halterman JS, Lynch KA, Conn KM, Hernandez TE, Perry TT, Stevens TP (2009) Environmental exposures end respiratory morbidity among very low birth weight infants at 1 year of life. Arch Dis Child 94:28–32

  15. Jobe AH, Bancalari E (2001) Bronchopulmonary dysplasia. Am J Respir Crit Care Med 163:1723–1729

    Article  CAS  PubMed  Google Scholar 

  16. Källén K (2001) The impact of maternal smoking during pregnancy on delivery outcome. Eur J Public Health 11:329–333

    Article  PubMed  Google Scholar 

  17. Ladomenou F, Kafatos A, Galanakis E (2009) Environmental tobacco smoke exposure as a risk factor for infections in infancy. Acta Paediatr 98:1137–1141

    Article  CAS  PubMed  Google Scholar 

  18. Lamarche-Vadel A, Blondel B, Truffer P, Burguet A, Cambonie G, Selton D et al (2004) Re-hospitalization in infants younger than 29 weeks’ gestation in the EPIPAGE cohort. Acta Paediatr 93:1340–1345

  19. Luciano A, Bolognani M, Biondani P, Ghizzi C, Zoppi G, Signori E (1998) The influence of maternal passive and light active smoking on intrauterine growth and body composition of the newborn. Eur J Clin Nutr 52:760–763

    Article  CAS  PubMed  Google Scholar 

  20. O’Callaghan MJ, Burns Y, Gray P, Harvey JM, Mohay HI, Rogers Y et al (1995) Extremely low birth weight and control infants at 2 years corrected age: a comparison of intellectual abilities, motor performance, growth and health. Early Hum Dev 40:115–128

  21. Samper MP, Jiménez-Muro A, Nerín I, Marqueta A, Ventura P, Rodríguez G (2012) Maternal active smoking and newborn body composition. Early Hum Dev 88:141–145

    Article  CAS  PubMed  Google Scholar 

  22. Sawnani H, Jackson T, Murphy T, Beckerman R, Simakajornboon N (2004) The effect of maternal smoking on respiratory and arousal patterns in preterm infants during sleep. Am J Respir Crit Care Med 169:733–738

    Article  PubMed  Google Scholar 

  23. Schneider J, Mitchell I, Singhal N, Kirk V, Hasan SU (2008) Prenatal cigarette smoke exposure attenuates recovery from hypoxemic challenge in preterm infants. Am J Respir Crit Care Med 178:520–526

    Article  PubMed  Google Scholar 

  24. Shah NR, Bracken MB (2000) A systematic review and meta-analysis of prospective studies on the association between maternal cigarette smoking and preterm delivery. Am J Obstet Gynecol 182:465–472

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Stevens TP, Sinkin RA, Hall CB, Maniscalco WM, McConnochie KM (2000) Respiratory syncytial virus and premature infants born at 32 weeks’ gestation or earlier: hospitalization and economic implications of prophylaxis. Arch Pediatr Adolesc Med 154:55–61

  26. Tucker J, McGuire W (2004) Epidemiology of preterm birth. BMJ 329:675–678

    Article  PubMed Central  PubMed  Google Scholar 

  27. Varvarigou AA, Fouzas S, Beratis NG (2010) Effect of prenatal tobacco smoke exposure on fetal growth potential. J Perinat Med 38:683–687

    PubMed  Google Scholar 

Download references

Authors Contribution

Dr Martinez contributed to the study design, data collection, data analysis, and writing of the manuscript. Dr Garcia-Meric contributed to the study design, data collection, and review of the manuscript. Dr Millet contributed to the study design, data collection, and review of the manuscript. Ms Aymeric-Ponsonnet contributed to the study design, data collection, and data analysis. Dr Khuder Alagha contributed to the study design and review of the manuscript. Pr Jean-Christophe Dubus contributed to the study design, data analysis, and writing of the manuscript

Author information

Authors and Affiliations

  1. Unité de pneumologie infantile, CHU Timone-Enfants, 264 rue Saint Pierre, 13385, Marseille CEDEX 5, France

    Stéphanie Martinez & Jean-Christophe Dubus

  2. Service de médecine néonatale, Hôpital la Conception, 147 boulevard Baille, 13385, Marseille CEDEX 5, France

    Patricia Garcia-Meric & Véronique Millet

  3. Réseau Naître et Devenir PACA Ouest et Corse du sud, 24 rue Brandis, 13005, Marseille, France

    Mellie Aymeric-Ponsonnet

  4. Clinique des bronches, allergie et sommeil, Hôpital Nord, chemin des Bourrely, 13915, Marseille CEDEX 20, France

    Khuder Alagha

Authors
  1. Stéphanie Martinez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Patricia Garcia-Meric
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Véronique Millet
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mellie Aymeric-Ponsonnet
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Khuder Alagha
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jean-Christophe Dubus
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jean-Christophe Dubus.

Additional information

Communicated by Peter de Winter

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Martinez, S., Garcia-Meric, P., Millet, V. et al. Tobacco smoke in infants with bronchopulmonary dysplasia. Eur J Pediatr 174, 943–948 (2015). https://doi.org/10.1007/s00431-015-2491-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00431-015-2491-y

Keywords

Search

Navigation