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Uncomplicated outcome after an accidental overdose of nevirapine in a newborn

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Abstract

We report the first case of a massive accidental overdose of nevirapine in a 1-week newborn, due to confusion between nevirapine (Viramune) and nelfinavir (Viracept). The drug was eliminated spontaneously and quickly. We only observed mild neutropenia and hyperlactatemia, which regressed on its own without any clinical complication. Despite the good evolution of this massive overdose, physicians should be aware of confusion risks between some antiretroviral drugs.

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Abbreviations

HIV:

human immunodeficiency virus

References

  1. Anderson BJ, Allegaert K, Holford NH (2006) Population clinical pharmacology of children: modelling covariate effects. Eur J Pediatr 165:819–829

    Article  PubMed  Google Scholar 

  2. Kappelhoff BS, van Leth F, Robinson PA, MacGregor TR, Baraldi E, Montella F, Uip DE, Thompson MA, Russell DB, Lange JM, Beijnen JH, Huitema AD, 2NN Study Group (2005) Are adverse events of nevirapine and efavirenz related to plasma concentrations? Antivir Ther 10:489–498

    PubMed  CAS  Google Scholar 

  3. Lambert BL, Lin SJ, Chang KY, Gandhi SK (1999) Similarity as a risk factor in drug-name confusion errors: the look-alike (orthographic) and sound-alike (phonetic) model. Med Care 37:1214–1225

    Article  PubMed  CAS  Google Scholar 

  4. Luzuriaga K, Bryson Y, McSherry G, Robinson J, Stechenberg B, Scott G, Lamson M, Cort S, Sullivan JL (1996) Pharmacokinetics, safety, and activity of nevirapine in human immunodeficiency virus type 1-infected children. J Infect Dis 174:713–721

    PubMed  CAS  Google Scholar 

  5. Max B, Mourikes N (1998) Confusion of nelfinavir and nevirapine. N Engl J Med 338:396–397

    Article  PubMed  CAS  Google Scholar 

  6. Shenton JM, Popovic M, Chen J, Masson MJ, Uetrecht JP (2005) Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat. Chem Res Toxicol 18:1799–18135

    Article  PubMed  CAS  Google Scholar 

  7. Taylor GP, Lyall EG, Back D, Ward C, Tudor-Williams G (2000) Pharmacological implications of lengthened in-utero exposure to nevirapine. Lancet 17:2134–2135

    Article  Google Scholar 

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Acknowledgements

The authors sincerely thank Isabelle Brasme for her kind rereading of the manuscript.

Conflict of interest statement

No conflict of interest declared.

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Authors and Affiliations

  1. Assistance Publique-Hôpitaux de Paris, Hôpital Robert-Debré, Pediatric Intensive Care Unit, 48, boulevard Sérurier, 75019, Paris, France

    Jean-François Brasme, Mounir Benhayoun & Stéphane Dauger

  2. Université Paris VII Denis-Diderot, IFR02, Site Xavier-Bichat, 16, rue Huchard, 75018, Paris, France

    Jean-François Brasme, Frédéric Mille, Mounir Benhayoun, Albert Faye, Natacha Teissier & Stéphane Dauger

  3. Assistance Publique-Hôpitaux de Paris, Hôpital Robert-Debré, Department of Pharmacy, Paris, France

    Frédéric Mille

  4. Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Vincent-de-Paul, Department of Clinical Pharmacology, 82 avenue Denfert-Rochereau, 75674, Paris Cedex 14, France

    Françoise Bavoux

  5. Assistance Publique-Hôpitaux de Paris, Hôpital Robert-Debré, Department of Pediatrics, Paris, France

    Albert Faye

  6. Assistance Publique-Hôpitaux de Paris, Hôpital Robert-Debré, Department of Pediatric Otorhinolaryngology, Paris, France

    Natacha Teissier

  7. Assistance Publique-Hôpitaux de Paris, Hôpital Jean Verdier, Department of Pediatrics, Avenue du 14 Juillet, 93143, Bondy, France

    Eric Lachassinne

Authors
  1. Jean-François Brasme
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  2. Frédéric Mille
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  3. Mounir Benhayoun
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  4. Françoise Bavoux
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  5. Albert Faye
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  6. Natacha Teissier
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  7. Eric Lachassinne
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  8. Stéphane Dauger
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Corresponding author

Correspondence to Stéphane Dauger.

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Brasme, JF., Mille, F., Benhayoun, M. et al. Uncomplicated outcome after an accidental overdose of nevirapine in a newborn. Eur J Pediatr 167, 689–690 (2008). https://doi.org/10.1007/s00431-007-0541-9

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  • DOI: https://doi.org/10.1007/s00431-007-0541-9

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