Skip to main content

Advertisement

Log in

IgG4-associated cholangitis with cholangiocarcinoma

  • Case Report
  • Published:
Virchows Archiv Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Abbreviations

AIP:

Autoimmune pancreatitis

AIPC:

Autoimmune pancreatocholangitis

ANA:

Antinuclear antibodies

IAC:

IgG4-associated cholangitis

CC:

Cholangiocarcinoma

HPF:

High-power field

MRCP:

Magnetic resonance cholangiopancreatography

PSC:

Primary sclerosing cholangitis

References

  1. Sarles H, Sarles JC, Muratore R, Guien C (1961) Chronic inflammatory sclerosis of the pancreas—an autonomous pancreatic disease? Am J Dig Dis 6:688–698

    Article  PubMed  CAS  Google Scholar 

  2. Sah RP, Chari ST, Pannala R, Sugumar A, Clain JE, Levy MJ et al (2010) Differences in clinical profile and relapse rate of type 1 vs type 2 autoimmune pancreatitis. Gastroenterology 139:140–148

    Article  PubMed  Google Scholar 

  3. Esposito I, Born D, Bergmann F, Longerich T, Welsch T, Giese NA et al (2008) Autoimmune pancreatocholangitis, non-autoimmune pancreatitis and primary sclerosing cholangitis: a comparative morphological and immunological analysis. PLoS One 3:e2539

    Article  PubMed  Google Scholar 

  4. Ghazale A, Chari ST, Zhang L, Smyrk TC, Takahashi N, Levy MJ et al (2008) Immunoglobulin G4-associated cholangitis: clinical profile and response to therapy. Gastroenterology 134:706–715

    Article  PubMed  Google Scholar 

  5. Webster GJ, Pereira SP, Chapman RW (2009) Autoimmune pancreatitis/IgG4-associated cholangitis and primary sclerosing cholangitis-overlapping or separate diseases? J Hepatol 51:398–402

    Article  PubMed  CAS  Google Scholar 

  6. Alderlieste YA, Van den Elzen BD, Rauws EA, Beuers U (2009) Immunoglobulin G4-associated cholangitis: one variant of immunoglobulin G4-related systemic disease. Digestion 79:220–228

    Article  PubMed  CAS  Google Scholar 

  7. Umemura T, Zen Y, Hamano H, Kawa S, Nakanuma Y, Kiyosawa K (2007) Immunoglobin G4-hepatopathy: association of immunoglobin G4-bearing plasma cells in liver with autoimmune pancreatitis. Hepatology 46:463–471

    Article  PubMed  CAS  Google Scholar 

  8. Bergquist A, Ekbom A, Olsson R, Kornfeldt D, Lööf L, Danielsson A et al (2002) Hepatic and extrahepatic malignancies in primary sclerosing cholangitis. J Hepatol 36:321–327

    Article  PubMed  Google Scholar 

  9. Oh HC, Kim JG, Kim JW, Lee KS, Kim MK, Chi KC et al (2008) Early bile duct cancer in a background of sclerosing cholangitis and autoimmune pancreatitis. Intern Med 47:2025–2028

    Article  PubMed  Google Scholar 

  10. Cheung MT, Lo IL (2008) IgG4-related sclerosing lymphoplasmacytic pancreatitis and cholangitis mimicking carcinoma of pancreas and Klatskin tumour. ANZ J Surg 78:252–256

    Article  PubMed  Google Scholar 

  11. Inoue H, Miyatani H, Sawada Y, Yoshida Y (2006) A case of pancreas cancer with autoimmune pancreatitis. Pancreas 33:208–209

    Article  PubMed  Google Scholar 

  12. Witkiewicz AK, Kennedy EP, Kennyon L, Yeo CJ, Hruban RH (2008) Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature. Hum Pathol 39:1548–1551

    Article  PubMed  Google Scholar 

  13. Gill J, Angelo N, Yeong ML, McIvor N (2009) Salivary duct carcinoma arising in IgG4-related autoimmune disease of the parotid gland. Hum Pathol 40:881–886

    Article  PubMed  CAS  Google Scholar 

  14. Hsing AW, McLaughlin JK, Olsen JH, Mellemkjar L, Wacholder S, Fraumeni JF Jr (1995) Cancer risk following primary hemochromatosis: a population-based cohort study in Denmark. Int J Cancer 60:160–162

    Article  PubMed  CAS  Google Scholar 

  15. Zhang L, Lewis JT, Abraham SC, Smyrk TC, Leung S, Chari ST et al (2010) IgG4+ plasma cell infiltrates in liver explants with primary sclerosing cholangitis. Am J Surg Pathol 34:88–94

    Article  PubMed  Google Scholar 

Download references

Acknowledgment

BKS was supported by a stipend of the Olympia-Morata program of the Medical Faculty of Heidelberg University.

Disclosure statement

The authors declare that no financial or other conflict of interest exists in relation to the content of the article.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Beate K. Straub.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Straub, B.K., Esposito, I., Gotthardt, D. et al. IgG4-associated cholangitis with cholangiocarcinoma. Virchows Arch 458, 761–765 (2011). https://doi.org/10.1007/s00428-011-1073-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-011-1073-2

Keywords

Navigation