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Specific features of colorectal cancer in patients with metabolic syndrome: a matched case-control analysis of 772 patients

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Abstract

Purpose

Although association between colorectal cancer (CRC) and metabolic syndrome (MetS) is established, specific features of CRC arising in patients presenting with MetS have not been clearly identified.

Method

All patients who underwent colectomy for CRC from January 2005 to December 2014 at Institut Mutualiste Montsouris were identified from a prospectively collected database and characteristics were compared in the entire population and in a 1:2 matched case-control analysis [variables on which matching was performed were CRC localization (right- or left-sided) and AJCC stage (0 to IV)].

Results

Out of the 772 identified patients, 98 (12.7%) presented with MetS. Entire population analysis revealed that CRC associated with MetS was more frequent in men (71.4 vs. 47.8%, p < 0.001), more often right-sided (71.4 vs. 50.4%, p < 0.001) and presented with less synchronous liver metastasis (4.1 vs. 8.7%, p = 0.002). Case-control analysis confirmed the gender association (p < 0.001) and showed HNPCC (p < 0.001) and history family of CRC (p = 0.010) to be significantly more frequent in Non-MetS patients.

Conclusions

CRC associated with MetS is more frequent in men, more often right-sided, and presents with fewer synchronous metastasis. Further investigations should be designed in order to confirm these results and to enhance our knowledge of carcinogenesis related to MetS.

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Abbreviations

MetS:

Metabolic syndrome

DM:

Diabetes mellitus

ASA:

American Society of Anesthesiology

COPD:

Chronic obstructive pulmonary disease

CRC:

Colorectal cancer

BMI:

Body mass index

AJCC:

American Joint Committee on Cancer

MSI:

Microsatellite instability

HNPCC:

Hereditary non-polyposis colorectal cancer

HCC:

Hepatocellular carcinoma

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Authors and Affiliations

  1. Department of Digestive Surgery, CHU Avicenne, Assistante Publique – Hôpitaux de Paris, Université Paris XIII, 125, rue de Stalingrad, 93000, Bobigny, France

    Alban Zarzavadjian Le Bian & Philippe Wind

  2. Laboratory of Medical Ethics and Legal Medicine, University Paris Descartes, 45, rue des Saint-Pères, 75006, Paris, France

    Alban Zarzavadjian Le Bian

  3. Department of Digestive Disease, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France

    Christine Denet, Nicolas Tabchouri, Christos Christidis, Thierry Perniceni, David Fuks & Brice Gayet

  4. Department of Digestive Endoscopy, Hôpital Privé de la Poterne des Peupliers, 8 place de l’Abbé Hénocque, 75013, Paris, France

    Gianfranco Donatelli

  5. Department of Oncology, Institut Mutualiste Montsouris, 42 Boulevard Jourdan, 75014, Paris, France

    Christophe Louvet & Mostefa Bennamoun

  6. Université Paris Descartes, 15 Rue de l’école de Médecine, 75005, Paris, France

    David Fuks & Brice Gayet

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  1. Alban Zarzavadjian Le Bian
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  2. Christine Denet
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Correspondence to Alban Zarzavadjian Le Bian.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Zarzavadjian Le Bian, A., Denet, C., Tabchouri, N. et al. Specific features of colorectal cancer in patients with metabolic syndrome: a matched case-control analysis of 772 patients. Langenbecks Arch Surg 403, 443–450 (2018). https://doi.org/10.1007/s00423-018-1677-y

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