Abstract
This investigation reports the effects of caffeinated chewing gum on fatigue and hormone response during repeated sprint performance with competitive cyclists. Nine male cyclists (mean ± SD, age 24 ± 7 years, VO2max 62.5 ± 5.4 mL kg−1 min−1) completed four high-intensity experimental sessions, consisting of four sets of 30 s sprints (5 sprints each set). Caffeine (240 mg) or placebo was administered via chewing gum following the second set of each experimental session. Testosterone and cortisol concentrations were assayed in saliva samples collected at rest and after each set of sprints. Mean power output in the first 10 sprints relative to the last 10 sprints declined by 5.8 ± 4.0% in the placebo and 0.4 ± 7.7% in the caffeine trials, respectively. The reduced fatigue in the caffeine trials equated to a 5.4% (90% confidence limit ±3.6%, effect size 0.25; ±0.16) performance enhancement in favour of caffeine. Salivary testosterone increased rapidly from rest (~53%) and prior to treatments in all trials. Following caffeine treatment, testosterone increased by a further 12 ± 14% (ES 0.50; ± 0.56) relative to the placebo condition. In contrast, cortisol concentrations were not elevated until after the third exercise set; following the caffeine treatment cortisol was reduced by 21 ± 31% (ES −0.30; ± 0.34) relative to placebo. The acute ingestion of caffeine via chewing gum attenuated fatigue during repeated, high-intensity sprint exercise in competitive cyclists. Furthermore, the delayed fatigue was associated with substantially elevated testosterone concentrations and decreased cortisol in the caffeine trials.
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Astorino TA, Roberson DW (2010) Efficacy of acute caffeine ingestion for short-term high intensity exercise performance: a systematic review. J Strength Cond Res 24:257–265
Beaven C, Hopkins W, Hansen K, Wood M, Cronin J, Lowe T (2008) Dose effect of caffeine on testosterone and cortisol responses to resistance exercise. Int J Sport Nutr Exerc Metab 18:131–141
Billaut F, Basset FA, Falgairette G (2005) Muscle coordination changes during intermittent cycling sprints. Neurosci Lett 380:265–269
Bird SP, Tarpenning KM, Marino FE (2006) Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men. Eur J Appl Physiol 97:225–238
Collomp K, Ahmaidi S, Audran M, Chanal JL, Prefaut CH (1991) Effects of caffeine ingestion on performance and anaerobic metabolism during the Wingate test. Int J Sports Med 12:439–443
Davis JK, Green JM (2009) Caffeine and anaerobic performance: ergogenic value and mechanisms of action. Sports Med 39:813–832
Doherty M, Smith PM, Hughes MC, Davidson RCR (2004) Caffeine lowers perceptual response and increases power output during high-intensity cycling. J Sports Sci 22:637–643
Enoka RM, Stuart DG (1992) Neurobiology of muscle fatigue. J Appl Physiol 72:1631–1642
Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51:83–133
Glaister M, Howatson G, Abraham CS, Lockey RA, Goodwin JE, Foley P, Mcinnes G (2008) Caffeine supplementation and multiple sprint running performance. Med Sci Sports Exerc 40:1835–1840
Graham TE (2001) Caffeine and exercise metabolism, endurance and performance. Sports Med 31:785–807
Granger DA, Schwartz EB, Booth A, Arentz M (1999) Salivary testosterone determination in studies of child health and development. Horm Behav 35:18–27
Greer F, Mclean C, Graham T (1998) Caffeine, performance, and metabolism during repeated Wingate exercise tests. J Appl Physiol 85:1502–1508
Hopkins WG (2002) A scale of magnitude for effect statistics. Internet Society for Sport Science. http://newstats.org/effectmag.html. Accessed 25 May 2008
Hopkins WG (2003) A spreadsheet for analysis of straightforward crossover trials. Internet Society for Sport Science. http://www.sportsci.org/resource/stats/xcrossover.xls
Kamimori GH, Karyekar CS, Otterstetter R, Cox DS, Balkin TJ, Belenky GL (2002) The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. Int J Pharm 234:159–167
Kraemer WJ, Ratamess NA (2005) Hormonal responses and adaptations to resistance exercise and training. Sports Med 35:339–361
Kraemer WJ, Marchitelli L, Gordon SE, Harman E, Dziados JE, Mello R, Frykman P, McCurry DS, Fleck J (1990) Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol 69:1442–1450
Lin AS, Uhde TW, Slate SO, Mccann UD (1997) Effects of intravenous caffeine administered to healthy males during sleep. Depress Anxiety 5:21–28
Linnamo V, Pakarinen A, Komi PV, Kraemer WJ (2005) Acute hormonal responses to submaximal and maximal heavy resistance and explosive exercises in men and women. J Strength Cond Res 19:566–571
Lovallo WR, Whitsett TL, Al’absi M, Sung BH, Vincent AS, Wilson MF (2005) Caffeine stimulation of cortisol secretion across the waking hours in relation to caffeine intake levels. Psychosom Med 67:734–739
Morelius E, Nelson N, Theodorson E (2004) Salivary cortisol and administration of concentrated oral glucose in newborn infants: improved detection limit and smaller sample volume without glucose interference. Scand J Clin Lab Invest 64:113–118
Nagaya N, Herrera A (1995) Effects of testosterone on synaptic efficacy at neuromuscular junctions in asexually dimorphic muscle of male frogs. J Physiol 483:141–153
Nehlig A, Debry G (1994) Caffeine and sports activity: a review. Int J Sports Med 15:215–223
Paton CD, Hopkins WG (2006) Variation in performance of elite cyclists from race to race. Eur J Sport Sci 6:25–31
Paton CD, Hopkins WG, Vollebregt L (2001) Little effect of caffeine ingestion on repeated sprints in team-sport athletes. Med Sci Sports Exerc 33:822–825
Pollard I (1988) Increases in plasma concentrations of steroids in the rat after the administration of caffeine: comparison with plasma disposition of caffeine. J Endocrinol 119:275–280
Rassing MR (1994) Chewing gum as a drug delivery system. Adv Drug Deliv Rev 13:89–121
Schneiker KT, Bishop D, Dawson B, Hackett LP (2006) Effects of caffeine on prolonged intermittent-sprint ability in team-sport athletes. Med Sci Sports Exerc 38:578–585
Selvage DJ, Lee SY, Parsons LH, Seo DO, Rivier C (2004) A hypothalamic-testicular neural pathway is influenced by brain catecholamines, but not testicular blood flow. Endocrinology 145:1750–1759
Sokmen B, Armstrong LE, Kraemer WJ, Casa DJ, Dias JC, Judelson DA, Maresh CM (2008) Caffeine use in sports: considerations for the athlete. J Strength Cond Res 22:978–986
Spratt DI, O’Dea LL, Schoenfeld D, Butler J, Raoe PN, Crowley WF (1988) Neuroendocrine-gonadal axis in men: frequent sampling of lh, fsh, and testosterone. Am J Physiol 254:658–666
Stuart GR, Hopkins WG, Cook C, Cairns SP (2005) Multiple effects of caffeine on simulated high-intensity team-sport performance. Med Sci Sports Exerc 37:1998–2005
Warren GL, Park ND, Maresca RD, McKibans KI, Millard-Stafford ML (2010) Effects of caffeine ingestion on muscular strength and endurance: a meta-analysis. Med Sci Sports Exerc 42:1375–1387
Wiles JD, Coleman D, Tegerdine M, Swaine IL (2006) The effects of caffeine ingestion on performance time, speed and power during a laboratory-based 1 km cycling time-trial. J Sports Sci 24:1165–1171
Williams JH (1991) Caffeine, neuromuscular function and high-intensity exercise performance. J Sports Med Phys Fit 31:481–489
Acknowledgments
The authors gratefully acknowledge the funding provided by the Waikato Institute of Technology to enable this study, and the assistance of Dr. David Rowlands on manuscript preparation.
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The authors received no assistance from any commercial company whose products were used in the study, and report no conflict of interest with this study and its results.
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Communicated by William Kraemer.
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Paton, C.D., Lowe, T. & Irvine, A. Caffeinated chewing gum increases repeated sprint performance and augments increases in testosterone in competitive cyclists. Eur J Appl Physiol 110, 1243–1250 (2010). https://doi.org/10.1007/s00421-010-1620-6
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DOI: https://doi.org/10.1007/s00421-010-1620-6