Abstract
In older healthy men, aerobic exercise capacity is related to postischemic flow-mediated dilation of the brachial artery (FMD), but corresponding data in a younger population is not available. In addition, whether submaximal aerobic exercise performance also correlates with this kind of vasomotor reactivity is not known. Therefore, in 15 nonsmoking young healthy men [age 27 (5) years; body mass index: 24 (2) kg/m2; mean (SD)] with different levels of ordinary physical activity, but not performing upper-extremity training, we measured FMD at 1 min after reactive hyperemia, and pulmonary oxygen uptake (V̇O2) at ventilatory anaerobic threshold (V̇O2AT) and at peak effort (peak V̇O2) during an incremental exercise on a treadmill. In our participants, FMD was 9.1 (3.4)%, V̇O2AT was 40.72 (5.92) ml/kg per min, and peak V̇O2 was 52.95 (8.13) ml/kg per min. Using bivariate Pearson’s correlation, and in separate multivariate regression analyses, V̇O2AT and peak VO2 showed a significant and reasonably good correlation with FMD (r=0.84, P<0.001 and r=0.77, P=0.001, respectively), independent of age, body mass index and serum total cholesterol (β=0.77, P<0.001, R2 of the overall model=0.79 and β=0.70, P<0.005, R2 of the overall model=0.69, respectively). Our data provide evidence suggesting that in young healthy men a higher submaximal and maximal aerobic exercise performance is associated with a greater FMD of peripheral conduit arteries.
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Acknowledgements
Dr E. A. Palmieri was supported in part by a grant from the Consorzio Interuniversitario per la Ricerca Cardiovascolare (2003).
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Palmieri, E.A., Palmieri, V., Innelli, P. et al. Aerobic exercise performance correlates with post-ischemic flow-mediated dilation of the brachial artery in young healthy men. Eur J Appl Physiol 94, 113–117 (2005). https://doi.org/10.1007/s00421-004-1285-0
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DOI: https://doi.org/10.1007/s00421-004-1285-0