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En face OCT in Stargardt disease

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the structural features of the macular region by enface OCT imaging in patients with clinical diagnosis of Stargardt disease, confirmed by the detection of ABCA4 mutations.

Methods

Thirty-two STGD patients were included in the study for a total of 64 eyes. All patients received a comprehensive ophthalmological examination, color fundus photography, fundus auto-fluorescence imaging and OCT. Five OCT scans were considered: ILM and RPE scans (both automatically obtained from the instrument), above-RPE slab, photoreceptor slab and sub-RPE slab (these last three manually obtained).

Results

ILM scans showed evident radial folds on the retinal surface in 8/64 eyes (12.5 %). In 6 of the 7 patients, these vitreo–retinal interface abnormalities were unilateral. The photoreceptor slab showed some macular alterations ranging from dis-homogeneous, hypo-reflective abnormalities (7/64 eyes, 11 %) to a homogeneous, well-defined, roundish, hypo-reflective area (17/64 eyes, 27 %) in all the eyes. The sub-RPE slab showed a centrally evident, hyper-reflective abnormality in 58/64 eyes (90.6 %). Superimposing the sub-RPE slab over the images corresponding to the photoreceptor slab, the area of the photoreceptor atrophy sharply exceeded that of the RPE atrophy (44/46 eyes, 96 %).

Conclusion

Enface OCT proved to be a clinically useful tool for the management of STGD patients, illustrating in vivo the structural abnormalities of the different retinal layers.

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Authors and Affiliations

  1. Careggi Teaching Hospital , Eye Clinic, University of Florence, Largo Brambilla 3, 50134, Florence, Italy

    Andrea Sodi, Dario Pasquale Mucciolo, Francesca Cipollini, Vittoria Murro, Orsola Caporossi, Gianni Virgili & Stanislao Rizzo

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  1. Andrea Sodi
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  2. Dario Pasquale Mucciolo
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  3. Francesca Cipollini
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  4. Vittoria Murro
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  5. Orsola Caporossi
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  6. Gianni Virgili
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  7. Stanislao Rizzo
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Corresponding author

Correspondence to Dario Pasquale Mucciolo.

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Compliance of ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of Interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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No funding was received for this research.

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Sodi, A., Mucciolo, D.P., Cipollini, F. et al. En face OCT in Stargardt disease. Graefes Arch Clin Exp Ophthalmol 254, 1669–1679 (2016). https://doi.org/10.1007/s00417-015-3254-1

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  • DOI: https://doi.org/10.1007/s00417-015-3254-1

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