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Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects

  • Glaucoma
  • Published:
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Abstract

Purpose

To compare anterior segment parameters in Chinese and Japanese subjects with angle closure using anterior segment optical coherence tomography (ASOCT).

Methods

One hundred and forty-two Japanese and one hundred and ninety-two Chinese subjects with primary angle closure (PAC) or primary angle-closure glaucoma (PACG) were recruited. All participants underwent A-scan biometry and ASOCT imaging (Visante, Carl Zeiss Meditec, Dublin, CA, USA). Customized software was used to measure ASOCT parameters in horizontal ASOCT scans. The parameters were compared, and multivariate analysis was performed to determine predictors of angle opening distance at 750 μm from the scleral spur (AOD750).

Results

Ethnic difference evaluated by multiple linear regression adjusted for age, gender, spherical equivalent, pupil diameter, and axial length showed that Japanese angle-closure subjects had significantly shallower anterior chamber depth (ACD;β = −0.3, p < 0.001), smaller anterior chamber area (ACA; β = −0.21, p = 0.02) and volume (ACV; β = −0.19, p = 0.01), greater lens vault (LV, β = 0.3, p < 0.001), lens thickness (LT; β = 0.48, p < 0.001), greater iris area (IArea; β = 0.19, p = 0.01), and more curved iris (ICurv; β = 0.16, p = 0.04). The significant determinants of AOD750 were iris thickness (IT; β = −0.21, p = 0.04), ICurv (β = −0.17, p = 0.04), pupil diameter (PD; β = −0.34, p = 0.001) and ACV (β = 0.32, p < 0.001) in Japanese; and IT (β = −0.25, p = 0.001), ACV (β = 0.37, p < 0.001), PD (β = −0.26, p = 0.001), and LV (β = −0.18, p = 0.03) in Chinese.

Conclusions

Compared to Chinese, Japanese angle-closure eyes have smaller and more crowded anterior segment with thicker lenses. ACV, IT, and PD are important factors for angle width in both races. These results suggest possible ethnic differences in angle-closure mechanism(s).

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Conflict of interest

All authors certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Authors and Affiliations

  1. Singapore Eye Research Institute and Singapore National Eye Center, 11 Third Hospital Avenue, Singapore, 168751, Singapore

    Henrietta Ho, Shamira A. Perera, Daniel H. Su, Tien Y. Wong, Monisha E. Nongpiur & Tin Aung

  2. Ozaki Eye Hospital, Hyuga, Japan

    Mineo Ozaki

  3. Mizoguchi Eye Clinic, Sasebo, Japan

    Takanori Mizoguchi

  4. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

    Mingguang He

  5. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Monisha E. Nongpiur & Tin Aung

Authors
  1. Henrietta Ho
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  2. Mineo Ozaki
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  3. Takanori Mizoguchi
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  4. Shamira A. Perera
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  5. Daniel H. Su
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  6. Mingguang He
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  7. Tien Y. Wong
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  8. Monisha E. Nongpiur
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  9. Tin Aung
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Corresponding author

Correspondence to Tin Aung.

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Henrietta Ho and Mineo Ozaki are joint first authors

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Ho, H., Ozaki, M., Mizoguchi, T. et al. Angle-closure glaucoma in Asians: comparison of biometric and anterior segment parameters between Japanese and Chinese subjects. Graefes Arch Clin Exp Ophthalmol 253, 601–608 (2015). https://doi.org/10.1007/s00417-015-2935-0

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  • DOI: https://doi.org/10.1007/s00417-015-2935-0

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