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Location and frequency of lesions in patients with IgG4-related ophthalmic diseases

  • Oculoplastics and Orbit
  • Published:
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Abstract

Background

It is well-known that the lacrimal gland (LG) may be affected in IgG4-related ophthalmic disease (IgG4ROD). Recently, IgG4-related ophthalmic lesions other than those of the lacrimal gland have been reported. However, no study to date has revealed the details of these lesions. This study was conducted to evaluate the location and frequency of lesions found in conjunction with IgG4ROD using radiological imaging.

Methods

Radiological images and clinical records of 65 patients collected from seven institutions in Japan were reviewed retrospectively. All patients had been pathologically diagnosed with IgG4ROD. Patients of mucosa-associated lymphoid tissue lymphoma associated with IgG4-related lesions were excluded. Orbital magnetic resonance imaging or computed tomography findings were evaluated.

Results

Of the 65 patients, 31 (47.7 %) had lesions involving the LG alone, whereas 34 (52.3 %) had lesions involving the areas other than LG, including eight patients who had lesions without any LG involvement. IgG4-related ophthalmic lesions included LG enlargement in 57 patients (87.7 %), trigeminal nerve branch enlargement in 25 (38.5 %), extraocular muscle enlargement in 16 (24.6 %), diffuse orbital fat lesions in 15 (23.1 %), orbital mass lesions in 11 (16.9 %), eyelid lesions in eight (12.3 %), and nasolacrimal duct lesion in one (1.5 %). Six patients (9.2 %) presented with visual disturbance due to optic nerve disturbance, eight (12.3 %) with a restriction of ocular movement, and 19 (29.2 %) with exophthalmos.

Conclusions

Thirty-four (52.3 %) of the 65 IgG4ROD patients had lesions in areas other than LG. Lesions were found in the trigeminal nerve branch including pterygopalatine fossa, extraocular muscles, orbital fat, eyelid, and nasolacrimal duct.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Ophthalmology, Mitoyo General Hospital, 708, Himehama, Toyohama-cho, Kanonji, Kagawa, 7691695, Japan

    Yuka Sogabe

  2. Section of Ophthalmology, National Hospital Organization Okayama Medical Center, 1711-1, Tamasu, Kitaku, Okayama, 7011154, Japan

    Koh-ichi Ohshima

  3. Ophthalmology Department, Kobe Kaisei Hospital, 3-11-15, Shinoharakita-machi, Nada-ku, Kobe, 6570068, Japan

    Atsushi Azumi

  4. Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences, 13-1, Takara-machi, Kanazawa, Ishikawa, 9208640, Japan

    Masayuki Takahira

  5. Department of Ophthalmology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 0608638, Japan

    Satoru Kase

  6. Department of Ophthalmology, The Cancer Institute Hospital of JFCR, 3-8-31 Ariake, Koto-ward, Tokyo, 1358550, Japan

    Hideki Tsuji

  7. Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 8128582, Japan

    Hiroshi Yoshikawa

  8. Department of Radiology, Mitoyo General Hospital, 708, Himehama, Toyohama-cho, Kanonji, Kagawa, 7691695, Japan

    Tetsuya Nakamura

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  1. Yuka Sogabe
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  2. Koh-ichi Ohshima
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Correspondence to Yuka Sogabe.

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Sogabe, Y., Ohshima, Ki., Azumi, A. et al. Location and frequency of lesions in patients with IgG4-related ophthalmic diseases. Graefes Arch Clin Exp Ophthalmol 252, 531–538 (2014). https://doi.org/10.1007/s00417-013-2548-4

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  • DOI: https://doi.org/10.1007/s00417-013-2548-4

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