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Soluble lutein in combination with brilliant blue as a new dye for chromovitrectomy

  • Retinal Disorders
  • Published:
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Abstract

Summary

A new dye for vitreoretinal surgery comprised of soluble lutein/zeaxanthin 1 % and brilliant blue 0.025 % is advantageous compared with other dyes currently used for chromovitrectomy, and showed no signs of toxicity at 1 month of follow-up.

Purpose

To evaluate the feasibility and safety of a dye [soluble lutein/zeaxanthin (LZ) 1 % and brilliant blue (BB) 0.025 %] for improving removal of vitreous, epiretinal membranes (ERM), and internal limiting membranes (ILM) in humans.

Methods

We prospectively evaluated 18 eyes treated surgically for a macular hole or ERM. Eighteen surgeons performed chromovitrectomy using the dye, and completed a questionnaire to evaluate the efficacy and safety of the dye. . Examinations included best-corrected visual acuity and intraocular pressure measurements and optical coherence tomography, fluorescein angiography, and autofluorescence performed at baseline and days 1, 7, and 30 postoperatively.

Results

The green dye was deposited on the posterior pole; vigorous dye flushing into the vitreous cavity was unnecessary. All surgeons reported that the ILM stained greenish-blue; 94.4 % reported ILM peeling adequate; the ERM stained poorly. No evidence of toxicity was observed.

Conclusion

The new dye deposited on the posterior pole due to its higher density. The ability to stain the ILM was similar to BB. The new dye has ability to stain the vitreous, hyaloid, and especially the ILM satisfactorily. The new dye may be useful during chromovitrectomy.

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Acknowledgments

Many thanks to the study coordinator Luci Silva for the efforts to conclude this study.

Proprietary interest

The use of the combination of lutein/zeaxanthin and brilliant blue in human eyes is protected by international patent law (international patent number 61/468,838). The study was sponsored by Kemin Inc., Des Moines, IA, USA.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil

    Emmerson Badaro, Bruno Furlani, Juliana Prazeres, Mauricio Maia, Acácio Alves Souza Lima, Diogo Souza-Martins, Cristina Muccioli, Luiz Filipe Adami Lucatto & Rubens Belfort Jr

  2. Ophthalmology Department, Vitreoretinal Surgery Unit, Universidade Federal de São Paulo, Rua Botucatu 822, São Paulo, 06023-062, Brazil

    Mauricio Maia

Authors
  1. Emmerson Badaro
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  2. Bruno Furlani
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  3. Juliana Prazeres
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  4. Mauricio Maia
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  5. Acácio Alves Souza Lima
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  6. Diogo Souza-Martins
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  7. Cristina Muccioli
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  8. Luiz Filipe Adami Lucatto
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  9. Rubens Belfort Jr
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Corresponding author

Correspondence to Mauricio Maia.

Additional information

Clinical trial registration number: NCT01627977

Local ethics committee number: 00553212.8.0000.5505

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Badaro, E., Furlani, B., Prazeres, J. et al. Soluble lutein in combination with brilliant blue as a new dye for chromovitrectomy. Graefes Arch Clin Exp Ophthalmol 252, 1071–1078 (2014). https://doi.org/10.1007/s00417-013-2539-5

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  • DOI: https://doi.org/10.1007/s00417-013-2539-5

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