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Catastrophic acute retinal necrosis syndrome associated with diffuse orbital cellulitis: a case report

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Abstract

Background

To report a case of severe acute retinal necrosis syndrome (ARN) associated with initial features of orbital cellulitis.

Methods

A 49-year-old immunocompetent woman presented with unilateral painful orbital inflammation associated with deep visual loss due to ARN. Polymerase chain reaction (PCR) for detection of viral DNA was applied to ocular fluids. Immunohistochemistry for detection of viral antigens and histopathologic studies were performed on orbital biopsy specimens.

Results

HSV-2 DNA was detected by PCR in ocular fluids. Orbital biopsy disclosed non-specific inflammation without viral replication. Orbital inflammation resolved rapidly after the initiation of antiviral drugs, whereas intraocular inflammation worsened. Final ophthalmic examination disclosed no light perception due to optic atrophy.

Conclusion

ARN and cellulitis may be associated. Consequently, ARN should be investigated in all patients with orbital inflammation, in order to initiate immediately an appropriate antiviral strategy.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, University of Paris VI Pitié-Salpêtrière Hospital, 47-83 Boulevard de l’Hôpital, 75013, Paris, France

    Olivier Rozenbaum & Bahram Bodaghi

  2. Department of Virology, Saint Vincent de Paul Hospital, Paris, France

    Flore Rozenberg

  3. Department of Pathology, Pitié-Salpêtrière Hospital, Paris, France

    Frederic Charlotte

Authors
  1. Olivier Rozenbaum
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  2. Flore Rozenberg
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  3. Frederic Charlotte
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  4. Bahram Bodaghi
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Corresponding author

Correspondence to Bahram Bodaghi.

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Rozenbaum, O., Rozenberg, F., Charlotte, F. et al. Catastrophic acute retinal necrosis syndrome associated with diffuse orbital cellulitis: a case report. Graefe's Arch Clin Exp Ophthalmol 245, 161–163 (2007). https://doi.org/10.1007/s00417-006-0265-y

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  • DOI: https://doi.org/10.1007/s00417-006-0265-y

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