Abstract
A recently proposed system of models for plutonium decorporation (SPD) was developed using data from an individual occupationally exposed to plutonium via a wound [from United States Transuranium and Uranium Registries (USTUR) Case 0212]. The present study evaluated the SPD using chelation treatment data, urine measurements, and post-mortem plutonium activities in the skeleton and liver from USTUR Case 0269. This individual was occupationally exposed to moderately soluble plutonium via inhalation and extensively treated with chelating agents. The SPD was linked to the International Commission on Radiological Protection (ICRP) Publication 66 Human Respiratory Tract Model (HRTM) and the ICRP Publication 30 Gastrointestinal Tract model to evaluate the goodness-of-fit to the urinary excretion data and the predictions of post-mortem plutonium retention in the skeleton and liver. The goodness-of-fit was also evaluated when the SPD was linked to the ICRP Publication 130 HRTM and the ICRP Publication 100 Human Alimentary Tract Model. The present study showed that the proposed SPD was useful for fitting the entire, chelation-affected and non-affected, urine bioassay data, and for predicting the post-mortem plutonium retention in the skeleton and liver at time of death, 38.5 years after the accident. The results of this work are consistent with the conclusion that Ca-EDTA is less effective than Ca-DTPA for enhancing urinary excretion of plutonium.
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References
Avtandilashvili M, Dumit S, Tolmachev SY (2018) USTUR whole-body Case 0212: 17-year follow-up of plutonium contaminated wound. Radiat Prot Dosim 178:160–169
Barrett PH, Bell BM, Cobelli C, Golde H, Schumitzky A, Vicini P, Foster DM (1998) SAAM II: simulation, analysis and modeling software for tracer and pharmacokinetic studies. Metabolis 4:484–492
Birchall A, Vostrotin V, Puncher M, Efimov A, Dorrian M-D, Sokolova A, Napier B, Suslova K, Miller S, Zhdanov A, Strom DJ, Scherpelz R, Schadilov A (2017) Mayak Worker Dosimetry System (MWDS-2013) for internally deposited plutonium: an overview. Radiat Prot Dosim 176:10–31
Breustedt B, Blanchardon E, Berard P, Fritsch P, Giussani A, Lopez MA, Luciani A, Nosske D, Piechowski J, Schimmelpfeng J, Sérandour AL (2009) Biokinetic modelling of DTPA decorporation therapy: the CONRAD approach. Radiat Prot Dosim 134:38–48
Castellani CM, Marsh JW, Hurtgen C, Blanchardon E, Berard P, Giussani A, Lopez MA (2013) IDEAS guidelines (Version 2) for the estimation of committed doses from incorporation monitoring data. European Radiation Dosimetry Group Report; Mar. Report No.: EURADOS Report 2013-01, Braunschweig. http://www.eurados.org/-/media/Files/Eurados/documents/EURADOS-Report-2013-01-online-version.pdf. Accessed 6 June 2018
Dumit S, Avtandilashvili M, Strom DJ, McComish SL, Tabatadze G, Tolmachev SY (2019) Improved modeling of plutonium-DTPA decorporation. Radiat Res. https://doi.org/10.1667/RR15188.1.
International Atomic Energy Agency (2004) Methods for assessing occupational radiation doses due to intakes of radionuclides. Safety Reports Series No. 37. STI/PUB/1190. IAEA Publications, Vienna. https://www-pub.iaea.org/MTCD/Publications/PDF/Pub1190/Pub1190_web.pdf. Accessed 26 June 2018
International Commission on Radiological Protection (1979) Limits for intakes of radionuclides by workers. ICRP Publication 30 (Part 1). Ann ICRP 3(3–4)
International Commission on Radiological Protection (1993) Age-dependent doses to members of the public from intake of radionuclides—part 2 ingestion dose coefficients. ICRP Publication 67. Ann ICRP 23(3–4)
International Commission on Radiological Protection (1994) Human respiratory tract model for radiological protection. ICRP Publication 66. Ann ICRP 24(1–3)
International Commission on Radiological Protection (2006) Human alimentary tract model for radiological protection. ICRP Publication 100. Ann ICRP 36(1–2)
International Commission on Radiological Protection (2015) Occupational intakes of radionuclides: part 1. ICRP Publication 130. Ann ICRP 44(2)
James AC, Sasser LB, Stuit DB, Glover SE, Carbaugh EH (2007) USTUR whole body Case 0269: demonstrating effectiveness of i.v. Ca-DTPA for Pu. Radiat Prot Dosim 127:449–455
Konzen K, Brey R, Miller S (2016) Plutonium-DTPA model application with USTUR Case 0269. Health Phys 110:59–65
Leggett RW, Eckerman KF, Khokhryakov VF, Suslova KG, Krahenbuhl MP, Miller SC (2005) Mayak worker study: an improved biokinetic model for reconstructing doses from internally deposited plutonium. Radiat Res 164:111–122
Luciani A, Polig E (2000) Verification and modification of the ICRP-67 model for plutonium dose calculation. Health Phys 78:303–310
McInroy JF, Boyd HA, Eutsler BC, Romero D (1985) The U.S. Transuranium Registry report of the 241Am content of a whole body. Part IV: preparation and analysis of the tissues and bones. Health Phys 49:587–621
Moody CA, Glover SE, Stuit DB, Filby RH (1998) Pre-concentration and separation of thorium, uranium, plutonium and americium in human soft tissues by extraction chromatography. J Radioanal Nucl Chem 234:183–187
National Council on Radiation Protection and Measurements (2006) Development of a biokinetic model for radionuclide-contaminated wounds and procedures for their assessment, dosimetry and treatment. NCRP Report No. 156. NCRP Publications, Bethesda
National Council on Radiation Protection and Measurements (2008) Management of persons contaminated with radionuclides: handbook. NCRP Report No. 161. NCRP Publications, Bethesda
Puncher M, Birchall A, Tolmachev SY (2017) The Mayak Worker Dosimetry System (MWDS 2013): a re-analysis of USTUR Case 0269 to determine whether plutonium binds to the lungs. Radiat Prot Dosim 176:50–61
Qu H, Stuit D, Glover SE, Love SF, Filby RH (1998) Preconcentration of plutonium and americium using the actinide-CU™ resin for human tissue analysis. J Radioanal Nucl Chem 234:175–181
Acknowledgements
The authors acknowledge the many helpful comments and suggestions from anonymous reviewers and the editor. Funding was provided by the Coordination for the Improvement of Higher Level Personnel (CAPES, Brazil), under Grant award no. 013355/2013-09 to S.D., and by the U.S. Department of Energy, Office of Domestic and International Health Studies (AU-13), under Grant award no. DE-HS0000073 to the USTUR. This study was performed as a part of the USTUR research program, which was reviewed and approved by Washington State University Institutional Review Board no. 11573.
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Dumit, S., Avtandilashvili, M., McComish, S.L. et al. Validation of a system of models for plutonium decorporation therapy. Radiat Environ Biophys 58, 227–235 (2019). https://doi.org/10.1007/s00411-018-00773-y
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DOI: https://doi.org/10.1007/s00411-018-00773-y