Abstract
Introduction
The conventional treatment for necrotizing otitis externa (NOE) is prolonged anti-pseudomonas therapy, with surgical treatment in non-responsive patients. The aim of the present study is to describe the course of management of patients with non-responsive NOE undergoing hyperbaric oxygen therapy (HBOT), and to investigate the importance of tissue biopsy for fungi in this group of patients.
Materials and methods
A retrospective study conducted between January 2010 and December 2013 at an Otolaryngology Head and Neck Surgery Department. Included were all 52 patients with NOE referred to our Medical Centre for further treatment including HBOT.
Results
Fifty-two consecutive patients, 29 men and 23 women, with a mean age of 70.6 years, were included in our study. Twenty seven (51.9%) underwent surgical debridement. No significant difference was found between the group having surgical intervention, and those who did not, with regard to sex, age, comorbidities, cranial nerve involvement or laboratory results. However, those who had surgical intervention had a statistically significant higher rate of fungal infection (P = 0.049). After completing 7 weeks of HBOT, a significantly lower WBC count was observed in the fungus-infected group (7000 vs 7.800, P = 0.03), and a tendency towards lower CRP levels in the fungus-infected group (16 vs 58, P = 0.087).
Conclusion
Patients with NOE should have a comprehensive surgical intervention when delayed healing is observed, because proper fungal culturing might change the course of treatment and improve prognosis.
Level of evidence
4.
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References
Ozgen B, Oguz KK, Cila A (2011) Diffusion MR imaging features of skull base osteomyelitis compared with skull base malignancy. AJNR Am J Neuroradiol 32(1):179–184
Rubin J, Yu VL (1988) Malignant external otitis: insights into pathogenesis, clinical manifestations, diagnoses, and therapy. Am J Med 85:391–398
Sreepada GS, Kwartler JA (2003) Skull base osteomyelitis secondary to malignant otitis externa. Curr Opin Otolaryngol Head Neck 11:316–323
Carfrae MJ, Kesser BW (2008) Malignant otitis externa. Otolaryngol Clin North Am 41:537–549
Jason AB, Michael JR (2014) Infections of the external ear. In: Flint PW, Haughey BH, Lund VJ, Niparko JK, Richardson MA, Robbins KT et al (eds) Cummings otolaryngology: head and neck surgery, 6th edn. Elsevier, Philadelphia, pp 2118–2120
Slattery WH III, Brackmann DE (1996) Skull base osteomyelitis. Malignant external otitis. Otolaryngol Clin North Am 29:795–806
Timon CI, O’Dwyer T (1989) Diagnosis, complications, and treatment of malignant otitis externa. Ir Med J 82:30–31
Mardinger O, Rosen D, Minkow B, Tulzinsky Z, Ophir D, Hirshberg A (2003) Temporomandibular joint involvement in malignant external otitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96(4):398–403
Loh S, Loh WS (2013) Malignant otitis externa: an asian perspective on treatment outcomes and prognostic factors. Otolaryngol Head Neck Surg 148(6):991–996
Narozny W, Kuczkowski J, Stankiewicz C, Kot J, Mikaszewski B, Przewozny T (2006) Value of hyperbaric oxygen in bacterial and fungal malignant external otitis treatment. Eur Arch Otorhinolaryngol 263(7):680–684
Denning DW (2000) Aspergillus species. In: Mandell GL, Bennett JE, Dolin R (eds) Principles and practice of infectious diseases, 5th edn. Churchill Livingstone, New York, pp 2674–2685
Hedayati MT, Pasqualotto AC, Warn PA, Bowyer P, Denning DW (2007) Aspergillus flavus: human pathogen, allergen and mycotoxin producer. Microbiology 153:1677–1692
Denning DW (1998) Invasive Aspergillus. Clin Infect Dis 26:781–805
Tibbles PM, Edelsberg JS (1996) Hyperbaric-oxygen therapy. N Engl J Med 334:1642–1648
Glikson E, Sagiv D, Wolf M, Shapira Y (2017) Necrotizing otitis externa: diagnosis, treatment, and outcome in a case series. Diagn Microbiol Infect Dis 87(1):74–78
Verim A, Naiboğlu B, Karaca Ç, Seneldir L, Külekçi S, Oysu Ç (2014) Clinical outcome parameters for necrotizing otitis externa. Otol Neurotol 35(2):371–376
Hatch JL, Bauschard MJ, Nguyen SA, Lambert PR, Meyer TA, McRackan TR (2018) Malignant otitis externa outcomes: a study of the University HealthSystem Consortium Database. Ann Otol Rhinol Laryngol 127(8):514–520
Phillips P, Bryce G, Shepherd J, Mintz D (1990) Invasive external otitis caused by Aspergillus. Rev Infect Dis 12:277–281
Davis JC, Gates GA, Lerner G, Davis MG, Mader JT, Dinesman A (1992) Adjuvant hyperbaric oxygen in malignant otitis externa. Laryngoscope 118:89–93
Shupak A, Greenberg E, Hardoff R, Gordon C, Melamed Y, Meyer WS (1989) Hyperbaric oxygenation for necrotizing (malignant) otitis externa. Arch Otolaryngol Head Neck Surg 115:1470–1475
Chandler JR (1968) Malignant external otitis. Laryngoscope 78:1257–1294
Meltzer PE, Kelemen G (1959) Pyocyaneous osteomyelitis of the temporal bone, mandible and zygoma. Laryngoscope 69:1300–1316
Finer G, Greenberg D, Leibovitz E, Leiberman A, Shelef I, Kapelushnik J (2002) Conservative treatment of malignant (invasive) external otitis caused by Aspergillus flavus with oral itraconazole solution in neutropenic patient. Scand J Infect Dis 34:227–229
Hanna E, Hughes G, Eliachar I, Wanamaker J, Tomford W (1993) Fungal osteomyelitis of the temporal bone: a review of reported cases. Ear Nose Throat J 72:532–541
Marzo SJ, Leonetti JP (2003) Invasive fungal and bacterial infections of the temporal bone. Laryngoscope 113:1503–1507
Hamzany Y, Soudry E, Preis M, Hadar T, Hilly O, Bishara J, Nageris BI (2011) Fungal malignant external otitis. J Infect 62(3):226–231
Gruber M, Roitman A, Doweck I, Uri N, Shaked-Mishan P, Kolop-Feldman A, Cohen-Kerem R (2015) Clinical utility of a polymerase chain reaction assay in culture-negative necrotizing otitis externa. Otol Neurotol 36(4):733–736
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Abu Eta, R., Gavriel, H., Stephen, K. et al. The significance of tissue biopsy for fungi in necrotizing otitis externa. Eur Arch Otorhinolaryngol 275, 2941–2945 (2018). https://doi.org/10.1007/s00405-018-5151-9
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DOI: https://doi.org/10.1007/s00405-018-5151-9