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Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions: a systematic review

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Abstract

Some laryngeal epithelial precursor lesions progress to invasive carcinoma and others do not. Routine light microscopic classification has limited value in predicting the evolution of these lesions. This article reviews the experience to date with the use of molecular markers for the prognostic evaluation of laryngeal epithelial precursor lesions. We conducted a thorough review of the published literature to identify those studies using biomarkers to predict malignant progression of laryngeal epithelial precursor lesions. Of the 336 studies identified in this systematic search, 15 met the inclusion criteria and form the basis of this review. Limited studies suggest that certain biomarkers are potentially reliable predictors of malignant progression including various regulators of cell adhesion and invasion (e.g. FAK, cortactin, osteopontin, and CD44v6) and proliferation-associated markers such as TGF-βRII and Kv3.4. The predictive value of these markers, however, has yet to be confirmed in large-scale prospective studies. Although the cell cycle-related proteins are the most frequently studied markers, none have been consistently reliable across multiple studies. The absence of standardization in methodologies, test interpretation, and other parameters may contribute to study inconsistencies. Various biomarkers have proved to have potential prognostic value and could be clinically relevant. The utility and prognostic power of these biomarkers should be confirmed in large, well-designed, standardized prospective studies.

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Authors and Affiliations

  1. Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain

    Juan P. Rodrigo, Juana María García-Pedrero & Carlos Suárez

  2. Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain

    Juan P. Rodrigo, Juana María García-Pedrero & Carlos Suárez

  3. Department of Otolaryngology-Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

    Robert P. Takes

  4. Department of Pathology, Woodland Hills Medical Center, Woodland Hills, CA, USA

    Lester D. R. Thompson

  5. Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

    Pieter J. Slootweg

  6. Oral Pathology, School of Dental Sciences and Dental Hospital, University of Liverpool, Liverpool, UK

    Julia A. Woolgar

  7. Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA

    William H. Westra

  8. Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands

    Ruud H. Brakenhoff

  9. ENT Clinic, University of Udine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy

    Alessandra Rinaldo & Alfio Ferlito

  10. Department of Pathology, Allegiance Health, Jackson, MI, USA

    Kenneth O. Devaney

  11. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Michelle D. Williams

  12. Department of Pathology, Warren Alpert School of Medicine at Brown University, Rhode Island Hospital, Providence, RI, USA

    Douglas R. Gnepp

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  1. Juan P. Rodrigo
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  2. Juana María García-Pedrero
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  14. Alfio Ferlito
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Corresponding author

Correspondence to Alfio Ferlito.

Additional information

This paper was written by members and invitees of the International Head and Neck Scientific Group (http://www.IHNSG.com).

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Rodrigo, J.P., García-Pedrero, J.M., Suárez, C. et al. Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions: a systematic review. Eur Arch Otorhinolaryngol 269, 1073–1083 (2012). https://doi.org/10.1007/s00405-011-1831-4

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  • DOI: https://doi.org/10.1007/s00405-011-1831-4

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