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Overweight and obesity do not determine worst prognosis in endometrioid endometrial carcinoma

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to investigate the impact of body mass index (BMI) on disease-free survival (DFS) and overall survival (OS) in women diagnosed with EEC and treated at the Brazilian National Cancer Institute.

Methods

The study comprised 849 women diagnosed with EEC who underwent surgical treatment between January, 2000 and December, 2011. The demographic and clinical characteristics of these patients were collected from medical records and their nutritional status was based on the BMI criteria. Univariate (OS and DFS) and multivariate analyses were performed using the Kaplan–Meier method and Cox proportional hazards models, respectively.

Results

About 83.2% of patients were obese or overweight at time of diagnosis, with a mean BMI of 31.83. Patients were followed for an average of 34.97 months. There were 111 recurrences (13.1%) and 140 deaths (16.5%), with mean DFS of 51.90 months and mean OS of 52.25 months. There was no significant association between BMI and DFS or OS. In multivariate analysis we did not find an increased hazard of recurrence or death among overweight or obese patients.

Conclusion

Overweight and obesity had no impact on EEC prognosis on the assessed cohort. Further studies are warranted.

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Funding

This work was supported by Ministry of Health (Brazil), Conselho Nacional Para Desenvolvimento Científico e Tecnológico (CNPq-Brazil).

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Authors and Affiliations

  1. Nutrition Department, Cancer Hospital II, Brazilian National Cancer Institute, Rua Equador, 831, Santo Cristo, Rio de Janeiro, RJ, 20220-410, Brazil

    Gabriela Villaça Chaves

  2. Biochemistry Department, State University of Rio de Janeiro, Avenida 28 de Setembro, 87/fundos, 4º andar, Vila Isabel, Rio de Janeiro, RJ, 20551-030, Brazil

    Tatiana de Almeida Simao

  3. Clinical Research Division, Rua Andre Cavalcanti, 37, Anexo, 5º andar, Centro, Rio de Janeiro, RJ, 20231-050, Brazil

    Anke Bergmann & Claudia Bessa Pereira Chaves

  4. Genetics Program, Brazilian National Cancer Institute, Rua Andre Cavalcanti, 37/4º andar, Centro, Rio de Janeiro, RJ, 20231-050, Brazil

    Miguel Angelo Martins Moreira

  5. Gynecologic Oncology Department, Cancer Hospital II, Brazilian National Cancer Institute, Rua Equador, 831, Santo Cristo, Rio de Janeiro, RJ, 20220-410, Brazil

    Claudia Bessa Pereira Chaves

  6. Molecular Carcinogenesis Program, Brazilian National Cancer Institute, Rua Andre Cavalcanti, 37 / 6° andar, Centro, Rio de Janeiro, RJ, 20231-050, Brazil

    Luis Felipe Ribeiro Pinto

Authors
  1. Gabriela Villaça Chaves
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  2. Tatiana de Almeida Simao
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  3. Luis Felipe Ribeiro Pinto
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  4. Miguel Angelo Martins Moreira
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  6. Claudia Bessa Pereira Chaves
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Contributions

GV Chaves: data analysis, manuscript writing/editing. TA Simão: data collection, manuscript writing/editing. LFR Pinto: protocol/project development, manuscript writing/editing. MAM Moreira: data collection, manuscript writing/editing. A Bergman: data analysis, manuscript writing/editing. CBP Chaves: protocol/project development, data collection and management, manuscript writing/editing.

Corresponding author

Correspondence to Claudia Bessa Pereira Chaves.

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Chaves, G.V., de Almeida Simao, T., Pinto, L.F.R. et al. Overweight and obesity do not determine worst prognosis in endometrioid endometrial carcinoma. Arch Gynecol Obstet 300, 1671–1677 (2019). https://doi.org/10.1007/s00404-019-05281-y

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  • DOI: https://doi.org/10.1007/s00404-019-05281-y

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