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Relationship between preeclampsia and vitamin D deficiency: a case control study

Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 24 June 2015

A Letter to the Editor to this article was published on 16 April 2015

Abstract

Purpose

There is paucity of literature pertaining to association between vitamin D deficiency and preeclampsia from sunshine-rich countries like India. Further none of the studies have reported on relation with severity of preeclampsia. This study was carried out with a purpose of studying relation between vitamin D deficiency and preeclampsia and its complications.

Methods

Seventy-four nulliparous preeclamptic women with singleton pregnancy and without any known medical disorder and 100 healthy nulliparous controls of same age were enrolled. Serum vitamin D concentration of the two groups was compared. We also compared the vitamin D level of women with mild and severe preeclampsia and with or without various complications of preeclampsia.

Results

Eighty-four percent of women were vitamin D deficient. Mean serum vitamin D was significantly lower among cases (9.7 ± 4.95 ng/ml) as compared to controls (14.8 ± 6.68 ng/ml); p = 0.0001. Women with mild preeclampsia (9.44 ± 5.63 ng/ml) had similar vitamin D level as those with severe disease (9.8 ± 4.79 ng/ml) (p = 0.811). There was no difference in vitamin D level of women with eclampsia (p = 0.956) or imminent eclampsia (p = 0.310) and those without these complications.

Conclusion

There is high prevalence of vitamin D deficiency among pregnant women in India. Women with preeclampsia had significantly lower vitamin D level as compared to normal women. Severity of the disease was not related to vitamin D level.

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Conflict of interest

We report no financial relation with any organization. We declare that authors have full control of the primary data. The authors declare that they have no conflict of interest.

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Correspondence to Neelam Aggarwal.

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Singla, R., Gurung, P., Aggarwal, N. et al. Relationship between preeclampsia and vitamin D deficiency: a case control study. Arch Gynecol Obstet 291, 1247–1251 (2015). https://doi.org/10.1007/s00404-014-3550-8

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  • DOI: https://doi.org/10.1007/s00404-014-3550-8

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