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Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival

  • Gynecologic Oncology
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Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

Inhibitors of tumor angiogenesis and metastasis are emerging as important new drug candidates for cancer therapy. Galectin-3 and heparanase have been shown to function in tumor progression and metastatic spread. Both of them exert pleiotropic effects; proliferation, cell migration, differentiation and tissue remodeling. The aim of this study was to investigate heparanase and galectin-3 expression in endometrioid and serous carcinomas of the endometrium and their relation with well-known prognostic factors, in addition to estrogen, progesterone, C-erbB-2, Ki-67 and p53.

Materials and methods

Sixty-four endometrial cancers, which include 24 serous types, were obtained from previously untreated patients. Immunohistochemical analysis of 64 carcinomas, 20 endometrial hyperplasia (ten of simple hyperplasia and ten of complex atypic hyperplasia) and 20 normal endometrium (ten of proliferative and ten of secretory) was performed.

Conclusion

This investigation suggests that the decreased expression of galectin-3 may be involved in the pathogenesis of endometrial carcinomas from normal endometrium to carcinoma. Also down-regulated stromal expression of galectin-3 in endometrial carcinoma may be involved in lymph node metastasis. Further studies on a larger advanced stage (FIGO stage 3–4) endometrial carcinoma group may determine the value of heparanase in the endometrial carcinoma.

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Acknowledgments

This work is supported by grant of ‘BAP’ comission of Pamukkale University, No 2008TPF009. Some of the findings about galectin-3 were presented orally in the 22nd European Pathology Congress and also this presentation was supported in part by grant of ‘BAP’ comission of Pamukkale University, No 2009KKP073 and 2007KRM001. We thank Dr. Mehmet Zencir and Dr. Özgür Önal for their contributions in statistical analysis and Mr. Emin Ateş for technical assistance.

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Authors and Affiliations

  1. Patoloji Laboratuarı, Siverek Devlet Hastanesi, 63700, Siverek/Sanliurfa, Turkey

    Çiğdem Berna Ege

  2. Pamukkale Üniversitesi Hastanesi, Morfoloji Binası, Kınıklı Kampüsü, 20070, Denizli, Turkey

    Metin Akbulut

  3. Patoloji Ana Bilim Dalı, Ege Üniversitesi Hastanesi, Bornova/Izmir, Turkey

    Osman Zekioğlu & Necmettin Özdemir

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  1. Çiğdem Berna Ege
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  2. Metin Akbulut
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Correspondence to Metin Akbulut.

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Ege, Ç.B., Akbulut, M., Zekioğlu, O. et al. Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival. Arch Gynecol Obstet 284, 1231–1239 (2011). https://doi.org/10.1007/s00404-010-1766-9

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