Skip to main content

Advertisement

SpringerLink
Log in

Down-regulation of tissue levels of serine protease inhibitor (vaspin) in psoriasis vulgaris patients: a possible mechanism of narrowband ultraviolet B radiation

  • Original Paper
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

Vaspin is a serine protease inhibitor of the serpin family which has an anti-inflammatory effect. It has an important role in the pathogenesis of some inflammatory diseases such as psoriasis. There are no previous studies comparing the effect of narrowband ultraviolet B (NB-UVB) radiation on tissue vaspin levels in psoriasis. So we aimed in this case–control study to estimate the possible role of vaspin in the pathogenesis of psoriasis, and to evaluate the effect of NB-UVB radiation on tissue vaspin in psoriasis. This study included 21 non-obese patients with moderate psoriasis and 20 non-obese clinically healthy age and sex matched controls. Patients underwent 24 sessions of NB-UVB radiation. A 4 mm punch skin biopsy was taken from all patients before and after treatment and from the controls for estimation of tissue vaspin level by enzyme-linked immunosorbent assay. Vaspin levels was significantly lower in patients before NB-UVB (99.72 pg/mg ± 12.11 pg/mg) compared to controls (257.34 pg/mg ± 28.11 pg/mg) with (P < 0.001). In addition, high significant difference was detected between vaspin levels in patients before (99.72 pg/mg ± 12.39 pg/mg) and after NB-UVB (190.92 pg/mg ± 27.61 pg/mg) with (P < 0.001). In conclusion, improvement of psoriatic plaques by NB-UVB is associated with an upregulation of tissue vaspin levels. Therefore, we suggest that vaspin has an important role in psoriasis pathogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Ataseven A, Kesli R (2016) Novel inflammatory markers in psoriasis vulgaris: vaspin, vascular adhesion protein-1 (VAP-1), and YKL-40. G Ital Dermatol Venereol 151(3):244–250

    PubMed  Google Scholar 

  2. Coban M, Tasli L, Turgut S, Özkan S, Tunç Ata M, Akın F (2016) Association of adipokines, insulin resistance, hypertension and dyslipidemia in patients with psoriasis vulgaris. Ann Dermatol. 28(1):74–79. https://doi.org/10.5021/ad.2016.28.1.74

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Coimbra S, Figueiredo A, Castro E, Rocha-Pereira P, Santos-Silva A (2012) The roles of cells and cytokines in the pathogenesis of psoriasis. Int J Dermatol 51(4):389–398

    Article  CAS  PubMed  Google Scholar 

  4. Diani M, Altomare G, Reali E (2016) T helper cell subsets in clinical manifestations of psoriasis. J Immunol Res 2016:7692024

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Fattouh M, El-Din AN, El-Hamd MA (2017) Role of lymphocyte subpopulations in the immunopathogenesis of psoriasis and the effect of narrow band UVB phototherapy on the immunological profile of psoriasis patients. Egypt J Immunol 24(1):105–117

    PubMed  Google Scholar 

  6. Fredriksson T, Petersson U (1978) Severe psoriasis-oral therapy with a new retinoid. Dermatologica 157:238–244

    Article  CAS  PubMed  Google Scholar 

  7. Hida K, Wada J, Eguchi J et al (2005) Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 102(30):10610–10615

    Article  CAS  PubMed  Google Scholar 

  8. Kawashima K, Torii K, Furuhashi T, Saito C, Nishio E, Nishida E, Shintani Y, Morita A (2011) Phototherapy reduces serum resistin levels in psoriasis patients. Photodermatol Photoimmunol Photomed 27(3):152–155. https://doi.org/10.1111/j.1600-0781.2011.00575.x

    Article  PubMed  Google Scholar 

  9. Lowes MA, Russell CB, Martin DA, Towne JE, Krueger JG (2013) The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends Immunol 34:174–181

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Menter A, Korman NJ, Elmets CA et al (2010) Guidelines of care for management of psoriasis and psoriatic arthritis: section 5. Guidelines of care for the treatment of psoriasis with phototherapy. J Am Acad Dermatol 62(1):114–135

    Article  PubMed  Google Scholar 

  11. Nestle FO, Kaplan DH, Barker J (2009) Psoriasis. N Engl J Med 361(5):496–509

    Article  CAS  PubMed  Google Scholar 

  12. Phalitakul S, Okada M, Hara Y et al (2011) Vaspin prevents TNF-alpha-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-kappa B and PKC theta activation in cultured rat vascular smooth muscle cells. Pharmacol Res 64(5):493–500

    Article  CAS  PubMed  Google Scholar 

  13. Priyadarssini M, Divya Priya D, Indhumathi S, Rajappa M, Chandrashekar L, Thappa DM (2016) Immunophenotyping of T cells in the peripheral circulation in psoriasis. Br J Biomed Sci 73(4):174–179

    Article  CAS  PubMed  Google Scholar 

  14. Saalbach A, Vester K, Rall K et al (2012) Vaspin—a link of obesity and psoriasis? Exp Dermatol 21(4):309–312. https://doi.org/10.1111/j.1600-0625.2012.01460.x

    Article  CAS  PubMed  Google Scholar 

  15. Saalbach A, Tremel J, Herbert D et al (2016) Anti-inflammatory action of keratinocyte-derived vaspin: relevance for the pathogenesis of psoriasis. Am J Pathol 186(3):639–651. https://doi.org/10.1016/j.ajpath.2015.10.030

    Article  CAS  PubMed  Google Scholar 

  16. Shibata S, Tada Y, Hau C et al (2011) Adiponectin as an anti-inflammatory factor in the pathogenesis of psoriasis: induction of elevated serum adiponectin levels following therapy. Br J Dermatol 164(3):667–670. https://doi.org/10.1111/j.1365-2133.2010.10123.x

    Article  CAS  PubMed  Google Scholar 

  17. Takahashi H, Tsuji H, Ishida-Yamamoto A, Iizuka H (2013) Serum level of adiponectin increases and those of leptin and resistin decrease following the treatment of psoriasis. J Dermatol 40(6):475–476. https://doi.org/10.1111/1346-8138.12122

    Article  PubMed  Google Scholar 

  18. Wallace AB (1951) The exposure and treatment of burns. Lancet 1(6653):501–504

    Article  CAS  PubMed  Google Scholar 

  19. Zieger K, Weiner J, Krause K, Schwarz M, Kohn M, Stumvoll M, Blüher M, Heiker JT (2018) Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway. Mol Cell Endocrinol 460:181–188. https://doi.org/10.1016/j.mce.2017.07.022

    Article  CAS  Google Scholar 

Download references

Funding

None.

Author information

Authors and Affiliations

  1. Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

    Khadiga Sayed Sayed, Eman Raafat Said & Mira Algorhary

  2. Dermatology and Venereology Department, National Research Center, Giza, Egypt

    Faisal Nouredin Mohammed

  3. Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt

    Laila Ahmed Rashed

Authors
  1. Khadiga Sayed Sayed
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eman Raafat Said
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Faisal Nouredin Mohammed
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mira Algorhary
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Laila Ahmed Rashed
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eman Raafat Said.

Ethics declarations

Conflict of interest

The author(s) declare that they have no competing interests.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of the research ethical committee (REC) of Dermatology Department, Faculty of medicine, Cairo University which is organized and operated according to the declaration of Helsinki for human subject researcher 2013.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sayed, K.S., Said, E.R., Mohammed, F.N. et al. Down-regulation of tissue levels of serine protease inhibitor (vaspin) in psoriasis vulgaris patients: a possible mechanism of narrowband ultraviolet B radiation. Arch Dermatol Res 311, 637–641 (2019). https://doi.org/10.1007/s00403-019-01947-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00403-019-01947-4

Keywords

Search

Navigation