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Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population

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Abstract

Several recent studies have demonstrated the possible involvement of the microsomal glutathione S-transferase 2 (MGST2) gene in the pathogenesis of psoriasis. The objectives of this work are to determine whether the genetic polymorphisms of the MGST2 gene were associated with an increased risk of psoriasis in Chinese patients. We first characterized the linkage disequilibrium pattern within MGST2 and identified single-nucleotide polymorphisms (SNPs) for tagging common genetic variants. Genotype- and haplotype-based analyses were then performed by genotyping the Tag SNPs in a large-scale sample of cases and controls. We characterized the linkage disequilibrium pattern within MGST2 using 12 densely distributed SNPs and identified 6 SNPs for tagging common genetic variants. We then performed an association analysis by genotyping the six SNPs in 552 cases and 384 controls, but none of the genotype- and haplotype-based analyses revealed significant evidence for association. We also performed family-based association analysis by genotyping the six SNPs in 95 trios; no evidence for association was identified. Our comprehensive genetic analysis of MGST2 common variants in a large Chinese sample of psoriasis did not provide any supporting evidence for MGST2 to be the susceptibility gene within the PSORS9 locus.

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Acknowledgements

This work was supported by grants from the key program of National Natural Science Foundation of China (30530670), the general program of National Natural Science Foundation of China (30371296), the Shanghai Science and Technology Committee (03DJ14008) and the Chinese Ministry of Education (2003). We are most grateful to all the families who have so willingly participated in this study, which made this study possible.

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Authors and Affiliations

  1. Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, 69 Meishan Road, Hefei, Anhui, 230032, People’s Republic of China

    Sen Yang, Kai-Lin Yan, Xue-Jun Zhang, Feng-Li Xiao, Xing Fan, Min Gao, Yong Cui, Peng-Guang Wang, Guo-Long Zhang, Liang-Dan Sun & Jian-Jun Liu

  2. The Key Laboratory of Gene Resource Utilization for Severe Diseases, Ministry of Education, Hefei, People’s Republic of China

    Sen Yang, Kai-Lin Yan, Xue-Jun Zhang, Feng-Li Xiao, Xing Fan, Min Gao, Yong Cui, Peng-Guang Wang, Guo-Long Zhang, Liang-Dan Sun & Jian-Jun Liu

  3. Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai, 201203, People’s Republic of China

    Zhi-Min Wang, Da-Zhi Wang, Kai-Yue Zhang & Wei Huang

  4. State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China

    Zhi-Min Wang

  5. Genome Institute of Singapore, Singapore, Singapore

    Jian-Jun Liu

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  1. Sen Yang
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  2. Kai-Lin Yan
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Correspondence to Xue-Jun Zhang or Wei Huang.

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Yang, S., Yan, KL., Zhang, XJ. et al. Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population. Arch Dermatol Res 298, 107–112 (2006). https://doi.org/10.1007/s00403-006-0670-4

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  • DOI: https://doi.org/10.1007/s00403-006-0670-4

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